Carthami Flos suppresses neutrophilic lung inflammation in mice, for which nuclear factor-erythroid 2-related factor-1 is required

Kim, Jeehye; Woo, Juyoun; Lyu, Ji Hyo; Song, Hyuk Hwan; Jeong, Hyein; Ha, Ki Tae; Choi, Jun Yong; Han, Chang Woo; Ahn, Kyung Seop; Oh, Sei Ryang; Sadikot, Ruxana T.; Kim, Kyun Ha; Joo, Myungsoo

doi:10.1016/j.phymed.2013.10.005

Cited by 15 publications

(10 citation statements)

References 28 publications

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“…The NF-κB and MAPK pathways have fundamental roles in controlling the induction and regulation of inflammatory and immune responses. The activation of NF-κB can regulate the expression of the specific target gene of pro-inflammatory cytokines, and are also present in several diseases, including asthma, septic shock and lung fibrosis ( 24 , 25 ). MAPKs are closely associated with the expression of inflammatory cytokines and chemokines upon pathogen challenge.…”

Section: Discussionmentioning

confidence: 99%

Evodiamine alleviates severe pneumonia induced by methicillin-susceptible Staphylococcus�aureus following cytomegalovirus reactivation through suppressing NF-κB and MAPKs

Chen

Zhou

2018

Int J Mol Med

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Viral and bacterial severe pneumonia are leading causes of mortality across the globe. Evodiamine (Evo), a botanical alkaloid, has anti-inflammatory and antibacterial properties. In the present study, the effect of Evo on severe pneumonia induced by methicillin-susceptible Staphylococcus aureus (MSSA) following cytomegalovirus (CMV) reactivation, and its mechanism, were evaluated. In vitro, the protein and mRNA expression levels of inflammatory cytokines were determined by enzyme-linked immunosorbent assay and reverse transcription-quantitative polymerase chain reaction analysis, respectively. The expression levels of associated proteins of the nuclear factor (NF)-κB and mitogen-activated protein kinase (MAPK) signaling pathways were measured by western blot analysis. In vivo, mortality rate, weight loss, histological changes, lung bacteria count, inflammatory cytokines, and the expression proteins of associated with the NF-κB and MAPK signaling pathways were examined. The results revealed that Evo dose-dependently reduced the protein and mRNA expression levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β, and inhibited the levels of phosphorylated (p-) inhibitor of NF-κBα, p-extracellular signal-regulated kinase, p-c-Jun N-terminal kinase and p-p38, and decreased the nuclear trans-location of NF-κB/p65 in BEAS-2B cells infected with MSSA. Furthermore, Evo markedly improved survival rate, decreased body weight loss and bacterial count, and attenuated lung histological alterations and the levels of inflammatory factors. In addition, the NF-κB and MAPK signaling pathways were significantly inhibited. Taken together, Evo effectively alleviated pneumonia via the NF-κB and MAPK pathways and may be a potential therapeutic agent for treating severe pneumonia.

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Section: Discussionmentioning

confidence: 99%

Evodiamine alleviates severe pneumonia induced by methicillin-susceptible Staphylococcus�aureus following cytomegalovirus reactivation through suppressing NF-κB and MAPKs

Chen

Zhou

2018

Int J Mol Med

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“…CF has been used to improve blood circulation by lowering the levels of blood lipids, 22 and can modulate neutrophilic lung inflammation. 8 Additionally, it is known that CF activates Nrf2; inhibits NF-kappaB activation; 23 and suppresses lipopolysaccharide-induced expression of interleukin-1 beta, inducible nitric oxide synthase, and cyclooxygenase-2 in RAW 264.7. 24 CF also has antioxidant and hepatoprotective effects in rats.…”

Section: Discussionmentioning

confidence: 99%

“… 3 CF has been used for centuries in Asia to treat cervical disk herniation, 4 shoulder pain, 5 degenerative knee arthritis, 6 urological diseases, 7 and lung inflammation. 8 In addition, CF is used for blood stasis caused by sprains or accidents, and to treat both baldness and pain caused by kidney deficiency. 9 In the small intestinal interstitial cells of Cajal (ICC) of mice, CF depolarized pacemaker potentials.…”

Section: Introductionmentioning

confidence: 99%

Carthami flos regulates gastrointestinal motility functions

Kim¹,

Bae²,

Kim³

2017

Integrative Medicine Research

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BackgroundGastrointestinal (GI) symptoms are common in the general population. This investigation studied the effects of Carthami flos (CF), a natural product, on GI motility.MethodsWe checked the intestinal transit rates (ITRs) or gastric emptying in normal and in GI-motility-dysfunction (GMD) mice in vivo. The GMD mice were made by acetic acid or streptozotocin.ResultsBoth ITRs and gastric emptying were increased by CF (0.0025–0.25 g/kg) dose dependently. Also, in the GMD mice models, acetic-acid-induced peritoneal irritation, and streptozotocin-induced diabetic mice, the ITRs were decreased compared to normal mice, and these decreases were inhibited by CF.ConclusionThese results suggest that CF is one of the good candidates for the development of a prokinetic agent that may regulate GI-motility functions.

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“…Three separate herbal product derivatives, ent-kaur-16-19-oic acid (KA) [ 41 ], the fruit hull of Gleditsia sinensis (FGS) [ 42 ], and Carthami Flos (CF) [ 43 ], have been shown to activate Nrf2 and to induce Nrf2-regulated gene expression in in vitro macrophage cell lines. CF in particular attenuated neutrophilic lung inflammation in mice, in the presence of Nrf2 [ 43 ]. Diallyl sulfide (DAS), a natural antioxidant found in garlic, induces Nrf2 activation and translocation in nuclei triggered by p38/ERK-signaling pathways in lung MRC-5 cells [ 44 ].…”

Section: Nuclear Factor Erythroid 2-like 2 (Nrf2): An Anti-inflammmentioning

confidence: 99%

“…In vitro experiments show that DS, KA, FGS, and CF exert their anti-inflammatory effects by activating Nrf2 and inducing Nrf2-regulated genes, including GCLC, NQO1, and HO1. Activation of Nrf2 occurs without reactive oxygen species production [ 41 – 43 ].…”

Section: Nuclear Factor Erythroid 2-like 2 (Nrf2): An Anti-inflammmentioning

confidence: 99%

Alternative and Natural Therapies for Acute Lung Injury and Acute Respiratory Distress Syndrome

Patel

Roy

Mehta

et al. 2018

BioMed Research International

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Introduction Acute respiratory distress syndrome (ARDS) is a complex clinical syndrome characterized by acute inflammation, microvascular damage, and increased pulmonary vascular and epithelial permeability, frequently resulting in acute respiratory failure and death. Current best practice for ARDS involves “lung-protective ventilation,” which entails low tidal volumes and limiting the plateau pressures in mechanically ventilated patients. Although considerable progress has been made in understanding the pathogenesis of ARDS, little progress has been made in the development of specific therapies to combat injury and inflammation. Areas Covered In recent years, several natural products have been studied in experimental models and have been shown to inhibit multiple inflammatory pathways associated with acute lung injury and ARDS at a molecular level. Because of the pleiotropic effects of these agents, many of them also activate antioxidant pathways through nuclear factor erythroid-related factor 2, thereby targeting multiple pathways. Several of these agents are prescribed for treatment of inflammatory conditions in the Asian subcontinent and have shown to be relatively safe. Expert Commentary Here we review natural remedies shown to attenuate lung injury and inflammation in experimental models. Translational human studies in patients with ARDS may facilitate treatment of this devastating disease.

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Carthami Flos suppresses neutrophilic lung inflammation in mice, for which nuclear factor-erythroid 2-related factor-1 is required

Cited by 15 publications

References 28 publications

Evodiamine alleviates severe pneumonia induced by methicillin-susceptible Staphylococcus�aureus following cytomegalovirus reactivation through suppressing NF-κB and MAPKs

Evodiamine alleviates severe pneumonia induced by methicillin-susceptible Staphylococcus�aureus following cytomegalovirus reactivation through suppressing NF-κB and MAPKs

Carthami flos regulates gastrointestinal motility functions

Alternative and Natural Therapies for Acute Lung Injury and Acute Respiratory Distress Syndrome

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