Cartilage defect repair in horses: Current strategies and recent developments in regenerative medicine of the equine joint with emphasis on the surgical approach

Cokelaere, Stefan; Malda, Jos; Weeren, P. R. van

doi:10.1016/j.tvjl.2016.02.005

Cited by 24 publications

(29 citation statements)

References 145 publications

(170 reference statements)

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“…Articular cartilage lesions are highly prevalent in horses (and in man) and potentially lead to post-traumatic osteoarthritis [1][2][3]. Options for cartilage repair procedures include a variety of established as well as emerging surgical techniques [4]. However, lesion size and depth must be taken into consideration in selecting the best possible procedure [5,6].…”

Section: Introductionmentioning

confidence: 99%

Semi‐automated International Cartilage Repair Society scoring of equine articular cartilage lesions in optical coherence tomography images

Moller

Pitkänen

Sarin

et al. 2016

Equine Veterinary Journal

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Section: Introductionmentioning

confidence: 99%

Semi‐automated International Cartilage Repair Society scoring of equine articular cartilage lesions in optical coherence tomography images

Moller

Pitkänen

Sarin

et al. 2016

Equine Veterinary Journal

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“…The success of this technique depends on the viability of chondrocytes in the graft and on the mechanical stability of the host–graft interface [ 32 ]. Furthermore, the use of osteochondral grafts transfer is limited by donor site availability in the autologous approach or joint congruency and host response in the case of allogeneic tissue [ 19 ]. The use of autologous micrografts overcomes some of these limitations, given that their collection is scarcely invasive, reducing donor site morbidity without influencing the grafts viability and overcoming the possible rejection issue related to allogeneic grafts.…”

Section: Discussionmentioning

confidence: 99%

“…Joint diseases represent the main cause of reduced athletic function for racehorses and are characterized by a degenerative process involving several components of the joints including cartilage, subchondral bone, and articular capsule [ 18 ]. Anti-inflammatory and analgesic drugs represent the standard treatment for mild defects, while articular cartilage curettage, osteophyte removal or surgical arthroscopy, and arthrodesis can be indicated for severe cartilage and bone degeneration [ 19 ]. Nevertheless, while all these therapies effectively reduce symptoms, they are not able to restore the physiological conditions in cartilage tissue.…”

Section: Introductionmentioning

confidence: 99%

Rationale and pre-clinical evidences for the use of autologous cartilage micrografts in cartilage repair

Viganò

Tessaro

Trovato³

et al. 2018

J Orthop Surg Res

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BackgroundThe management of cartilage lesions is an open issue in clinical practice, and regenerative medicine represents a promising approach, including the use of autologous micrografts whose efficacy was already tested in different clinical settings. The aim of this study was to characterize in vitro the effect of autologous cartilage micrografts on chondrocyte viability and differentiation and perform an evaluation of their application in racehorses affected by joint diseases.Materials and methodsMatched human chondrocytes and micrografts were obtained from articular cartilage using Rigenera® procedure. Chondrocytes were cultured in the presence or absence of micrografts and chondrogenic medium to assess cell viability and cell differentiation. For the pre-clinical evaluation, three racehorses affected by joint diseases were treated with a suspension of autologous micrografts and PRP in arthroscopy interventions. Clinical and radiographic follow-ups were performed up to 4 months after the procedure.ResultsAutologous micrografts support the formation of chondrogenic micromasses thanks to their content of matrix and growth factors, such as transforming growth factor β (TGFβ) and insulin-like growth factor 1 (IGF-1). On the other hand, no significant differences were observed on the gene expression of type II collagen, aggrecan, and SOX9. Preliminary data in the treatment of racehorses are suggestive of a potential in vivo use of micrografts to treat cartilage lesions.ConclusionThe results reported in this study showed the role of articular micrografts in the promoting chondrocyte differentiation suggesting their potential use in the clinical practice to treat articular lesions.Electronic supplementary materialThe online version of this article (10.1186/s13018-018-0983-y) contains supplementary material, which is available to authorized users.

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“…This review article by Stefan Cokelaere and colleagues in the Netherlands discusses current strategies and recent developments in regenerative medicine of the equine joint with emphasis on the surgical approach .…”

Section: Cartilage Defect Repair In Horsesmentioning

confidence: 99%

Highlights of recent clinically relevant papers

Wright¹

2016

Equine Veterinary Education

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Cartilage defect repair in horses: Current strategies and recent developments in regenerative medicine of the equine joint with emphasis on the surgical approach

Cited by 24 publications

References 145 publications

Semi‐automated International Cartilage Repair Society scoring of equine articular cartilage lesions in optical coherence tomography images

Semi‐automated International Cartilage Repair Society scoring of equine articular cartilage lesions in optical coherence tomography images

Rationale and pre-clinical evidences for the use of autologous cartilage micrografts in cartilage repair

Highlights of recent clinically relevant papers

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