Cartilage mechanobiology: the response of chondrocytes to mechanical force

Wheeler, Cameron; Fitzgerald, Jonathan B.; Grodzinsky, Alan J.

doi:10.1097/01.bco.0000178255.17447.01

Cited by 3 publications

(2 citation statements)

References 90 publications

(50 reference statements)

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“…Researchers have suggested that mechanical forces do have some vital role in controlling and manipulating chondroctye behavior with respect to connective tissue remodelling and homeostasis, especially that possibly linked with the described diseases [27,28]. However, there is not much knowledge as to how these mechanical forces activate the chondrocytes when transitioning between healthy and disease states.…”

Section: Discussionmentioning

confidence: 99%

Biokinetic Mechanisms Linked With Musculoskeletal Health Disparities: Stochastic Models Applying Tikhonov’s Theorem to Biomolecule Homeostasis

Saha

Liang

Kohles

2011

Journal of Nanotechnology in Engineering and Medicine

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Multiscale technology and advanced mathematical models have been developed to control and characterize physicochemical interactions, respectively, enhancing cellular and molecular engineering progress. Ongoing tissue engineering development studies have provided experimental input for biokinetic models examining the influence of static or dynamic mechanical stimuli (Saha, A. K., and Kohles, S. S., 2010, “A Distinct Catabolic to Anabolic Threshold Due to Single-Cell Nanomechanical Stimulation in a Cartilage Biokinetics Model,” J. Nanotechnol. Eng. Med., 1(3) p. 031005; 2010, “Periodic Nanomechanical Stimulation in a Biokinetics Model Identifying Anabolic and Catabolic Pathways Associated With Cartilage Matrix Homeostasis,” J. Nanotechnol. Eng. Med., 1(4), p. 041001). In the current study, molecular regulatory thresholds associated with specific disease disparities are further examined through applications of stochastic mechanical stimuli. The results indicate that chondrocyte bioregulation initiates the catabolic pathway as a secondary response to control anabolic processes. In addition, high magnitude loading produced as a result of stochastic input creates a destabilized balance in homeostasis. This latter modeled result may be reflective of an injurious state or disease progression. These mathematical constructs provide a framework for single-cell mechanotransduction and may characterize transitions between healthy and disease states.

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Section: Discussionmentioning

confidence: 99%

Biokinetic Mechanisms Linked With Musculoskeletal Health Disparities: Stochastic Models Applying Tikhonov’s Theorem to Biomolecule Homeostasis

Saha

Liang

Kohles

2011

Journal of Nanotechnology in Engineering and Medicine

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“…Whether it is direct or indirect (via ECM), any mechanical stress at the tissue level results in either deformation of chondrocytes and ECM biomolecules [41] and/or aggravation of cellular kinetics or biochemical activity at the nanoscale [42]. Previous studies suggest that mechanical force plays an important role in regulating chondrocyte behavior, subsequently guiding ECM structural molecule homeostasis [43,44]. However, the mechanotransduction pathways by which chondrocytes and other biomolecules respond to mechanical forces are not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Periodic Nanomechanical Stimulation in a Biokinetics Model Identifying Anabolic and Catabolic Pathways Associated With Cartilage Matrix Homeostasis

Saha

Kohles

2010

Journal of Nanotechnology in Engineering and Medicine

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Enhancing the available nanotechnology to describe physicochemical interactions during biokinetic regulation will strongly support cellular and molecular engineering efforts. In a recent mathematical model developed to extend the applicability of a statically loaded, single-cell biomechanical analysis, a biokinetic regulatory threshold was presented (Saha and Kohles, 2010, “A Distinct Catabolic to Anabolic Threshold Due to Single-Cell Static Nanomechanical Stimulation in a Cartilage Biokinetics Model,” J. Nanotechnol. Eng. Med., 1(3), p. 031005). Results described multiscale mechanobiology in terms of catabolic to anabolic pathways. In the present study, we expand the mathematical model to continue exploring the nanoscale biomolecular response within a controlled microenvironment. Here, we introduce a dynamic mechanical stimulus for regulating cartilage molecule synthesis. Model iterations indicate the identification of a biomathematical mechanism balancing the harmony between catabolic and anabolic states. Relative load limits were defined to distinguish between “healthy” and “injurious” biomolecule accumulations. The presented mathematical framework provides a specific algorithm from which to explore biokinetic regulation.

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Biomechanical Aspects: Joint Injury and Osteoarthritis

Chai¹,

Stevens²,

Grodzinsky³

Topics in Bone Biology

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Cartilage mechanobiology: the response of chondrocytes to mechanical force

Cited by 3 publications

References 90 publications

Biokinetic Mechanisms Linked With Musculoskeletal Health Disparities: Stochastic Models Applying Tikhonov’s Theorem to Biomolecule Homeostasis

Biokinetic Mechanisms Linked With Musculoskeletal Health Disparities: Stochastic Models Applying Tikhonov’s Theorem to Biomolecule Homeostasis

Periodic Nanomechanical Stimulation in a Biokinetics Model Identifying Anabolic and Catabolic Pathways Associated With Cartilage Matrix Homeostasis

Biomechanical Aspects: Joint Injury and Osteoarthritis

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