Cartilage morphology at 2–3 years following anterior cruciate ligament reconstruction with or without concomitant meniscal pathology

Wang, Xinyang; Wang, Yuan‐Yuan; Bennell, Kim L; Wrigley, Tim V.; Cicuttini, Flavia Maria; Fortin, Karine; Saxby, David J.; Ginckel, Ans Van; Dempsey, Alasdair R.; Grigg, Nicole; Vertullo, Christopher J.; Feller, Julian A.; Whitehead, Timothy S.; Lloyd, David G.; Bryant, Adam

doi:10.1007/s00167-015-3831-1

Cited by 23 publications

(61 citation statements)

References 49 publications

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“…Moreover, these same ACLRs and half of the control group have previously been shown (45) to have tibial bone plate areas (i.e. the size of the knee) that were similar, but the ACLRs had less tibial articular cartilage volume with more defects.…”

Section: Discussionmentioning

confidence: 83%

“…In our study, and in the previous investigations (20,26,42,49), each participant's tibiofemoral contact forces were scaled to their body mass (45) or weight (21,26,53). The rationale for scaling is that heavier individuals will have larger tibiofemoral contact forces, and thus to compare different populations some form of normalization of the magnitudes of the contact forces is required.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Tibiofemoral Contact Forces in the Anterior Cruciate Ligament–Reconstructed Knee

Saxby

Bryant

Modenese

et al. 2016

Medicine &Amp; Science in Sports &Amp; Exercise

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Tibiofemoral Contact Forces in the Anterior Cruciate Ligament–Reconstructed Knee

Saxby

Bryant

Modenese

et al. 2016

Medicine &Amp; Science in Sports &Amp; Exercise

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“…Twenty‐eight participants with isolated ACLR (i.e., without concomitant meniscal pathology) were recruited from two experienced orthopaedic surgeons specializing in ACLR surgery in Melbourne, Australia. These participants were a subgroup of a larger longitudinal cohort study, and the joint morphology at baseline has been published . Inclusion criteria for ACLR participants were: (i) aged 18–40 years; (ii) ACLR performed for an acute ACL tear within 6 months of injury; (iii) ACLR performed arthroscopically using ipsilateral semitendinosus and gracilis (hamstring) autograft; and (iv) ACLR performed 2–3 years previously.…”

Section: Methodsmentioning

confidence: 99%

“…No chondral surgery was undertaken as all lesions were less than ICRS grade 3. A post‐surgical rehabilitation protocol emphasizing rapid restoration of knee joint range of motion and quadriceps (particularly vastus medialis) function was prescribed …”

Section: Methodsmentioning

confidence: 99%

Cartilage quantitative T2 relaxation time 2–4 years following isolated anterior cruciate ligament reconstruction

Wang

Wrigley

Bennell

et al. 2018

Journal Orthopaedic Research

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Cartilage T2 relaxation time in isolated anterior cruciate ligament reconstruction (ACLR) without concomitant meniscal pathology and their changes over time remain unclear. The purpose of this exploratory study was to: (i) compare cartilage T2 relaxation time (T2 values) in people with isolated ACLR at 2-3 years post-surgery (baseline) and matched healthy controls and; (ii) evaluate the subsequent 2-year change in T2 values in people with ACLR. Twenty-eight participants with isolated ACLR and nine healthy volunteers underwent knee magnetic resonance imaging (MRI) at baseline; 16 ACLR participants were re-imaged 2 years later. Cartilage T2 values in full thickness, superficial layers, and deep layers were quantified in the tibia, femur, trochlear, and patella. Between-group comparisons at baseline were performed using analysis of covariance adjusting for age, sex, and body mass index. Changes over time in the ACLR group were evaluated using paired sample t-tests. ACLR participants showed significantly higher (p = 0.03) T2 values in the deep layer of medial femoral condyle at baseline compared to controls (mean difference 4.4 ms [13%], 95%CI 0.4, 8.3 ms). Over 2 years, ACLR participants showed a significant reduction (p = 0.04) in T2 value in the deep layer of lateral tibia (mean change 1.4 ms [-7%], 95%CI 0.04, 2.8 ms). The decrease in T2 values suggests improvement in cartilage composition in the lateral tibia (deep layer) of ACLR participants. Further research with larger ACLR cohorts divided according to meniscal status and matched healthy cohorts are needed to further understand cartilage changes post-ACLR. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2022-2029, 2018.

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“…Tearing of the menisci compromises its mechanical integrity, reducing the ability of the tissue to redistribute mechanical loading [4–6]. Meniscectomy [7] and meniscal pathology [8] following ACL injury have been linked to cartilage degeneration and the development of post-traumatic osteoarthritis.…”

Section: 0 Introductionmentioning

confidence: 99%

Loading of the medial meniscus in the ACL deficient knee: A multibody computational study

Guess

Razu

2017

Medical Engineering & Physics

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The menisci of the knee reduce tibiofemoral contact pressures and aid in knee lubrication and nourishment. Meniscal injury occurs in half of knees sustaining anterior cruciate ligament injury and the vast majority of tears in the medial meniscus transpire in the posterior horn region. In this study, computational multibody models of the knee were derived from medical images and passive leg motion for two female subjects. The models were validated against experimental measures available in the literature and then used to evaluate medial meniscus contact force and internal hoop tension. The models predicted that the loss of anterior cruciate ligament (ACL) constraint increased contact and hoop forces in the medial menisci by a factor of 4 when a 100 N anterior tibial force was applied. Contact forces were concentrated in the posterior horn and hoop forces were also greater in this region. No differences were found in contact or hoop tension between the intact and ACL deficient (ACLd) knees when only a 5 Nm external tibial torque was applied about the long axis of the tibia. Combining a 100 N anterior tibial force and a 5 Nm external tibial torque increased posterior horn contact and hoop forces, even in the intact knee. The results of this study show that the posterior horn region of the medial meniscus experiences higher contact forces and hoop tension, making this region more susceptible to injury, especially with the loss of anterior tibia motion constraint provided by the ACL. The contribution of the dMCL in constraining posterior medial meniscus motion, at the cost of higher posterior horn hoop tension, is also demonstrated.

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Cartilage morphology at 2–3 years following anterior cruciate ligament reconstruction with or without concomitant meniscal pathology

Abstract: III.

Cited by 23 publications

References 49 publications

Tibiofemoral Contact Forces in the Anterior Cruciate Ligament–Reconstructed Knee

Tibiofemoral Contact Forces in the Anterior Cruciate Ligament–Reconstructed Knee

Cartilage quantitative T2 relaxation time 2–4 years following isolated anterior cruciate ligament reconstruction

Loading of the medial meniscus in the ACL deficient knee: A multibody computational study

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