Cartilage oligomeric matrix protein and hyaluronic acid are sensitive serum biomarkers for early cartilage lesions in the knee joint

Jiao, Qiang; Wei, Lei; Chen, Chongwei; Li, Pengcui; Wang, Xiaohu; Li, Yongping; Guo, Li; Zhang, Congming; Wei, Xiaochun

doi:10.3109/1354750x.2015.1118547

Cited by 35 publications

(31 citation statements)

References 24 publications

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“…Interestingly, no genes were found to be down‐regulated at all time points. Genes up‐regulated at all time points included extracellular matrix (ECM) components ( Fn1 , collagens 3, 5, and 6, Cthrc1 , Thbs3 ), matrix metabolic enzymes ( Mmp3 ) and Wnt signaling proteins ( Sfrp2 and Wisp2 ). In addition, it included ECM and cell adhesion proteins (SRPX2 and TNN) and a synovial fibroblast cell surface marker (THY1).…”

Section: Resultsmentioning

confidence: 99%

Global molecular changes in a tibial compression induced ACL rupture model of post‐traumatic osteoarthritis

Chang

Sebastian

Murugesh

et al. 2016

Journal Orthopaedic Research

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Joint injury causes post‐traumatic osteoarthritis (PTOA). About ∼50% of patients rupturing their anterior cruciate ligament (ACL) will develop PTOA within 1–2 decades of the injury, yet the mechanisms responsible for the development of PTOA after joint injury are not well understood. In this study, we examined whole joint gene expression by RNA sequencing (RNAseq) at 1 day, 1‐, 6‐, and 12 weeks post injury, in a non‐invasive tibial compression (TC) overload mouse model of PTOA that mimics ACL rupture in humans. We identified 1446 genes differentially regulated between injured and contralateral joints. This includes known regulators of osteoarthritis such as MMP3, FN1, and COMP, and several new genes including Suco, Sorcs2, and Medag. We also identified 18 long noncoding RNAs that are differentially expressed in the injured joints. By comparing our data to gene expression data generated using the surgical destabilization of the medial meniscus (DMM) PTOA model, we identified several common genes and shared mechanisms. Our study highlights several differences between these two models and suggests that the TC model may be a more rapidly progressing model of PTOA. This study provides the first account of gene expression changes associated with PTOA development and progression in a TC model. © 2016 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. J Orthop Res 35:474–485, 2017.

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Section: Resultsmentioning

confidence: 99%

Global molecular changes in a tibial compression induced ACL rupture model of post‐traumatic osteoarthritis

Chang

Sebastian

Murugesh

et al. 2016

Journal Orthopaedic Research

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“…Likewise gender differences were seen for uCTX-II, MMP-3, uCol2-1 NO 2 and sHA 45 . Cartilage damage and concentrations of sCOMP, sCTX-II, sMMP-3, sPIIINP, and sHA were determined in 79 patients who underwent knee arthroscopy or total knee replacement in a study by Jiao and colleagues 47 . PIIANP, serum CTX-II, HA and COMP were measured in this study, but only HA and COMP concentrations were found to be significantly higher in the knee OA patients with early signs of cartilage damage 47 .…”

Section: Clinical Validation Of Existing Oa Biomarkersmentioning

confidence: 99%

“…Cartilage damage and concentrations of sCOMP, sCTX-II, sMMP-3, sPIIINP, and sHA were determined in 79 patients who underwent knee arthroscopy or total knee replacement in a study by Jiao and colleagues 47 . PIIANP, serum CTX-II, HA and COMP were measured in this study, but only HA and COMP concentrations were found to be significantly higher in the knee OA patients with early signs of cartilage damage 47 . These results suggest that sCOMP and HA concentrations can be used to predict early cartilage lesions in the knee.…”

Section: Clinical Validation Of Existing Oa Biomarkersmentioning

confidence: 99%

Osteoarthritis Year in Review 2016: biomarkers (biochemical markers)

Mobasheri

Bay‐Jensen

Spil

et al. 2017

Osteoarthritis and Cartilage

131

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There has been steady progress in osteoarthritis (OA) biomarker research in 2016. Several novel biomarkers were identified and new technologies have been developed for measuring existing biomarkers. However, there has been no "quantum leap" this past year and identification of novel early OA biomarkers remains challenging. During the past year, OARSI published a set of recommendations for the use of soluble biomarkers in clinical trials, which is a major step forward in the clinical use of OA biomarkers and bodes well for future OA biomarker development.

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“…During tissue turnover, molecular biomarkers of OA are derived from tissue matrices released into fluids (i.e., blood, urine, or synovial fluid) [15,16]. They reflect bone or cartilage turnover and synovial metabolism, and can be used as an assessment of pathophysiological processes [17,18].…”

Section: Introductionmentioning

confidence: 99%

Anti-Osteoarthritic Effects of a Mixture of Dried Pomegranate Concentrate Powder, Eucommiae Cortex, and Achyranthis Radix 5:4:1 (g/g) in a Surgically Induced Osteoarthritic Rabbit Model

Choi

Kang

Kim³

et al. 2020

Nutrients

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In this study, we aimed to determine the synergistic effects of a formula consisting of dried pomegranate concentrate powder, Eucommiae Cortex, and Achyranthis Radix 5:4:1 (g/g) (PCP:EC:AR) in a surgically induced osteoarthritis (OA) rabbit model. PCP:EC:AR was orally administered once per day. Knee thickness, maximum extension of the knee joint, gross articular defect area, and the histopathological appearance of the cartilage were monitored, along with serum collagen type II C-telopeptide (CTX-II), cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and subchondral IL-1β and TNF-α levels. Roentgenographic images were also evaluated. PCP:EC:AR significantly inhibited the surgically induced increase in knee thickness, maximum extension of both knees, knee thickness after capsule exposure, gross femoral and tibial articular defect areas, loss of the knee joint area, serum and synovial COMP, CTX-II, and MMP expression, and synovial IL-1β, and TNF-α expression. In addition, surgically induced narrowing of the knee bones, loss of the joint area, cartilage damage, and osteophyte formation were reduced. PCP:EC:AR suppressed the surgically induced increases in the Mankin score, and subchondral IL-1β and TNF-α immunolabeled cell numbers. PCP:EC:AR exerted potent OA protective effects in a surgically induced OA rabbit model.

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Cartilage oligomeric matrix protein and hyaluronic acid are sensitive serum biomarkers for early cartilage lesions in the knee joint

Cited by 35 publications

References 24 publications

Global molecular changes in a tibial compression induced ACL rupture model of post‐traumatic osteoarthritis

Global molecular changes in a tibial compression induced ACL rupture model of post‐traumatic osteoarthritis

Osteoarthritis Year in Review 2016: biomarkers (biochemical markers)

Anti-Osteoarthritic Effects of a Mixture of Dried Pomegranate Concentrate Powder, Eucommiae Cortex, and Achyranthis Radix 5:4:1 (g/g) in a Surgically Induced Osteoarthritic Rabbit Model

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