Cartilage Oligomeric Matrix Protein Levels in Type 2 Diabetes Associated with Primary Knee Osteoarthritis Patients

Vertti, Rubén Daniel Arellano Pérez; Muñiz, Lizette Sarai Aguilar; Martínez, Javier Morán; Galarza, Faviel Francisco González; Astorga, Rafael Argüello

doi:10.1089/gtmb.2018.0184

Cited by 26 publications

(19 citation statements)

References 48 publications

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“…Some previous studies reported a significantly higher prevalence of primary osteoarthritis among subjects with DM than among subjects without DM, as well as significant associations with glycemic control and the duration of diabetes. Obesity may be associated with the onset of osteoarthritis [42][43][44]. We are unsure why the present study showed a negative impact of orthoarthritis on DME.…”

Section: Discussionmentioning

confidence: 54%

Systemic and local diseases associated with the development of diabetic macular edema among Japanese patients with diabetes mellitus

Kume

Kashiwagi

2020

Preprint

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Background Diabetic macular edema (DME) causes severe vision loss among patients with diabetes mellitus (DM). We aimed to investigate systemic and local diseases associated with the development of DME among a Japanese population. Methods A total of 3.11 million Japanese subjects who were registered in the database of the Japan Medical Data Center from 2005 to 2014 were analyzed. Subjects with DM were defined as individuals who had been prescribed any therapeutic medications for DM, and associated diseases were analyzed. The periods analyzed were one year before the development of DME among patients with DME and one year before the last visit to an ophthalmic clinic among patients without DME. Results A total of 17,403 patients with DM satisfied the inclusion and exclusion criteria, and 420 patients developed DME. Univariate analysis revealed significant associations between 55 diseases, including 39 systemic and 16 local diseases, and DME development. The logistic analysis identified 21 systemic diseases and 10 local diseases as significant factors associated with DME development. Various types of systemic and local diseases were associated with DME development. Conclusion Subjects with DM who present these risk factors must be carefully monitored to prevent visual impairment.

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Section: Discussionmentioning

confidence: 54%

Systemic and local diseases associated with the development of diabetic macular edema among Japanese patients with diabetes mellitus

Kume

Kashiwagi

2020

Preprint

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“…Some previous studies reported a significantly higher prevalence of primary osteoarthritis among subjects with DM than among those without DM, as well as significant associations with glycemic control and the duration of diabetes. Obesity may be associated with the onset of osteoarthritis, [41][42][43] though we are unsure why our study showed a negative impact of osteoarthritis on DME. According to Taylor et al, diabetes may increase the risk of kidney stone formation by altering the composition of the urine, and insulin resistance may play a role in stone formation [44].…”

Section: Discussionmentioning

confidence: 59%

Systemic and ocular diseases associated with the development of diabetic macular edema among Japanese patients with diabetes mellitus

Kume

Kashiwagi

2020

BMC Ophthalmol

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Background: Diabetic macular edema (DME) causes severe vision loss among patients with diabetes mellitus (DM). We aimed to investigate systemic and ocular diseases associated with the development of DME in a Japanese population. Methods: A total of 3.11 million Japanese subjects who were registered in the database of the Japan Medical Data Center from 2005 to 2014 were analyzed. Subjects with DM were defined as individuals who had been prescribed any therapeutic medications for DM, and associated diseases were analyzed. The periods assessed were one year before the development of DME among patients with DME and one year before the last visit to an ophthalmic clinic among patients without DME. Results: A total of 17,403 patients with DM satisfied the inclusion and exclusion criteria, and 420 patients developed DME. Univariate analysis revealed significant associations between 55 diseases, including 39 systemic and 16 ocular diseases, and DME development. Logistic analysis identified 21 systemic diseases and 10 ocular diseases as significant factors associated with DME development. Conclusion: Various types of systemic and ocular diseases are associated with DME development. Subjects with DM who present these risk factors must be carefully monitored to prevent visual impairment.

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“…According to this, increased levels of the cartilage oligomeric matrix protein (COMP) can be found in the synovial fluid of T2D subjects. Therefore, treating T2D may minimize glycemic control parameters and inflammation, along with synovial fluid COMP levels and OA progression ( 74 ).…”

Section: Metainflammation In Oamentioning

confidence: 99%

Purinergic System Signaling in Metainflammation-Associated Osteoarthritis

et al. 2020

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Inflammation triggered by metabolic imbalance, also called metainflammation, is low-grade inflammation caused by the components involved in metabolic syndrome (MetS), including central obesity and impaired glucose tolerance. This phenomenon is mainly due to excess nutrients and energy, and it contributes to the pathogenesis of osteoarthritis (OA). OA is characterized by the progressive degeneration of articular cartilage, which suffers erosion and progressively becomes thinner. Purinergic signaling is involved in several physiological and pathological processes, such as cell proliferation in development and tissue regeneration, neurotransmission and inflammation. Adenosine and ATP receptors, and other members of the signaling pathway, such as AMP-activated protein kinase (AMPK), are involved in obesity, type 2 diabetes (T2D) and OA progression. In this review, we focus on purinergic regulation in osteoarthritic cartilage and how different components of MetS, such as obesity and T2D, modulate the purinergic system in OA. In that regard, we describe the critical role in this disease of receptors, such as adenosine A2A receptor (A2AR) and ATP P2X7 receptor. Finally, we also assess how nucleotides regulate the inflammasome in OA.

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Cartilage Oligomeric Matrix Protein Levels in Type 2 Diabetes Associated with Primary Knee Osteoarthritis Patients

Cited by 26 publications

References 48 publications

Systemic and local diseases associated with the development of diabetic macular edema among Japanese patients with diabetes mellitus

Systemic and local diseases associated with the development of diabetic macular edema among Japanese patients with diabetes mellitus

Systemic and ocular diseases associated with the development of diabetic macular edema among Japanese patients with diabetes mellitus

Purinergic System Signaling in Metainflammation-Associated Osteoarthritis

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