Cartilage repair of the knee with Hyalograft C:® Magnetic Resonance Imaging assessment of the glycosaminoglycan content at midterm

Abstract

Purpose The aim of this study was to assess the stability of the glycosaminoglycan (GAG) content in the long term after matrix-associated autologous chondrocyte transplantation (MACT) with Hyalograft C in the knee over a follow-up period of one year. Methods In this cross-sectional evaluation, 11 patients after MACT of the knee consented to delayed gadoliniumenhanced magnetic resonance imaging of cartilage (dGEMRIC) measurements. The mean post-operative interval before the first MR examination was 40.6±22.0 months, and the second MR examination was carried out after another 12 months. The Lysholm score was assessed for clinical evaluation. Quantitative T1 measurements after intravenous negatively charged MR contrast agent administration were performed. Global post-contrast T1 of the reference cartilage and the repair tissue and a relative postcontrast T1 value were calculated. Results The Lysholm score improved significantly from 59.8±12.9 at baseline to 86.1±15.7 at the second visit (p< 0.01). The mean global T1 of the repair tissue (1st visit 581.3±126.4 ms; 2nd visit 684.1±169.9 ms; p00.104) and the mean relative T1 value showed stable results over one year (1st visit 0.81±0.28; 2nd visit 0.76±0.32; p00.4). Conclusions The study demonstrated stable glycosaminoglycan content of the repair tissue after MACT at midterm.

Revision surgery after third generation autologous chondrocyte implantation in the knee

“…Autologous chondrocyte implantation is an established procedure for treatment of full cartilage defects in the knee joint with several satisfactory results in the literature [19][20][21][22][23]. Although little is known about cases when joint revision surgery is needed.…”

Cartilage Repair Surgery: Outcome Evaluation by Using Noninvasive Cartilage Biomarkers Based on Quantitative MRI Techniques?

“…However, Trattnig et al reported that T1-Gd was lower in repair tissue than in normal cartilage 2.8 and 4.7 years after MACI [23, 165]. About 4 and 5 years after MACI, a stable T1-Gd was observed by Brix et al [175]. T1-Gd was not significantly different between repair tissue and normal cartilage 9 to 18 years after ACI according to Vasiliadis et al [177].…”

Relationship Between Quantitative MRI Biomarkers and Patient-Reported Outcome Measures After Cartilage Repair Surgery: A Systematic Review

“…Eight studies 3,6,15,22,23,26,30,33 found a statistical relationship between postoperative quantitative cartilage imaging values and PRO measures following cartilage repair and restoration, while 6 studies 2,7,12,20,25,29 found no statistical relationships between these parameters. The mean level of evidence (LoE) was not different between studies reporting a statistical relationship (LoE = 3.3 ± 0.9) and those that reported no statistical relationship (LoE = 3.0 ± 1.3; P = .67).…”