Carvacrol and thymol components inhibiting Pseudomonas aeruginosa adherence and biofilm formation

Abed, Soumya El; Saad, Ibnsouda Koraichi; Latrache, Hassan; Ghizlane, Zineb; Hind, Mouradi; Remmal, Adnane

doi:10.5897/ajmr11.275

Cited by 54 publications

(9 citation statements)

References 33 publications

(32 reference statements)

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“…In an initial study we assessed each naturally occurring phenol and its derivatives against planktonic cells. Studies have shown that thymol ( 1a ) and carvacrol ( 2a ) compromise the outer membrane of Gram-negative bacteria increasing the permeability of the cytoplasm (El Abed et al, 2011). The 2- and 4-allyl compounds for thymol ( 1a ) and carvacrol ( 2a ) all showed an increase in potency toward planktonic cells when compared to the parent compounds, as seen in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Naturally occurring phenols such as thymol ( 1a ), carvacrol ( 2a ), and eugenol ( 3a ) have been shown to present antimicrobial properties against both planktonic cells and biofilms (Nostro et al, 2007; El Abed et al, 2011; Adil et al, 2014; Burt et al, 2014; Ceylan and Ugur, 2015; Kifer et al, 2016; Lee et al, 2017; Miladi et al, 2017; Raei et al, 2017; Mohamed et al, 2018). Here we demonstrated that 2-allyl ( 1b and 2b ) and 4-allyl derivatives ( 1c and 2c) of thymol ( 1a ) and carvacrol ( 2a ) showed an increase in potency in comparison to the parent compounds against planktonic cells in both growth inhibition and killing assays.…”

Section: Resultsmentioning

confidence: 99%

“…In this communication, thymol ( 1a ), carvacrol ( 2a ), and eugenol ( 3a ) as well as guaiacol are evaluated along with several 2- and 4- allyl, 2-methallyl and 2- n -propyl derivatives (Figure 1). Thymol ( 1a ), carvacrol ( 2a ), and eugenol ( 3a ) have also been evaluated for their ability to inhibit adherence and biofilm formation as well as biofilm eradication (Nostro et al, 2007; El Abed et al, 2011; Adil et al, 2014; Burt et al, 2014; Moran et al, 2014; Ceylan and Ugur, 2015; Kifer et al, 2016; Kim et al, 2016; Gaio et al, 2017; Lee et al, 2017; Miladi et al, 2017; Oh et al, 2017; Raei et al, 2017; Mohamed et al, 2018; Vazquez-Sanchez et al, 2018). Oh et al (2017) has shown that thymol ( 1a ) and carvacrol ( 2a ) have anti-biofilm effects on the formation of E. coli and Salmonella .…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Activity of Naturally Occurring Phenols and Derivatives Against Biofilm and Planktonic Bacteria

et al. 2019

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Biofilm-forming bacteria present formidable challenges across diverse settings, and there is a need for new antimicrobial agents that are both environmentally acceptable and relatively potent against microorganisms in the biofilm state. The antimicrobial activity of three naturally occurring, low molecular weight, phenols, and their derivatives were evaluated against planktonic and biofilm Staphylococcus epidermidis and Pseudomonas aeruginosa. The structure activity relationships of eugenol, thymol, carvacrol, and their corresponding 2- and 4-allyl, 2-methallyl, and 2- and 4-n-propyl derivatives were evaluated. Allyl derivatives showed a consistent increased potency with both killing and inhibiting planktonic cells but they exhibited a decrease in potency against biofilms. This result underscores the importance of using biofilm assays to develop structure-activity relationships when the end target is biofilm.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Activity of Naturally Occurring Phenols and Derivatives Against Biofilm and Planktonic Bacteria

et al. 2019

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“…Studies confirmed that thymol can inhibit the biofilms formation of Candida tropicalis and Enterococcus faecalis ( Veras et al, 2014 ; Chatrath et al, 2019 ). In studies about P. aeruginosa and Candida albicans ( El et al, 2011 ; Jafri and Ahmad, 2020 ), thymol is speculated to affect early stage biofilms by inhibiting adhesion. Thymol can significantly reduce the expression of the pga gene that codes the PGA exopolysaccharide ( Wang et al, 2017 ), the main component of the Actinobacillus pleuropneumoniae biofilm matrix.…”

Section: Inhibiting Eps Productionmentioning

confidence: 99%

Strategies for Interfering With Bacterial Early Stage Biofilms

Zhang

Lin

et al. 2021

Front. Microbiol.

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Biofilm-related bacteria show high resistance to antimicrobial treatments, posing a remarkable challenge to human health. Given bacterial dormancy and high expression of efflux pumps, persistent infections caused by mature biofilms are not easy to treat, thereby driving researchers toward the discovery of many anti-biofilm molecules that can intervene in early stage biofilms formation to inhibit further development and maturity. Compared with mature biofilms, early stage biofilms have fragile structures, vigorous metabolisms, and early attached bacteria are higher susceptibility to antimicrobials. Thus, removing biofilms at the early stage has evident advantages. Many reviews on anti-biofilm compounds that prevent biofilms formation have already been done, but most of them are based on compound classifications to introduce anti-biofilm effects. This review discusses the inhibitory effects of anti-biofilm compounds on early stage biofilms formation from the perspective of the mechanisms of action, including hindering reversible adhesion, reducing extracellular polymeric substances production, interfering in the quorum sensing, and modifying cyclic di-GMP. This information can be exploited further to help researchers in designing new molecules with anti-biofilm activity.

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“…with MIC values approaching 0.01 μg/mL [27]. Volatile oil play also an essential role in protecting and even preventing biofilm development which is very important as presented above [29]. However, the same lipophilicity capacity of essential oil, relevant for their good antiinfective properties, constitutes also their (19,42) have been found active against various infective strains (Table 1 and Figure 1).…”

Section: Plant-based Secondary Compounds With Antimicrobial Propertiesmentioning

confidence: 99%

Plant-Derived Compounds against Microbial Infections and Cancers

Bitchagno¹,

Nchiozem-Ngnitedem²,

Wandji³

et al. 2021

Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health

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Plants synthesize and preserve a variety of metabolites known as natural products. Many of them are easily extractable and can be used as starting material or chemical scaffolds for various purposes, especially in drug discovery. Numbers of reports have listed valuable candidates with privilege scaffolds currently in active development as drugs. New compounds with anticancer and antiinfective activities have been discovered recently, some presented these backbones. The present book chapter aims to highlight these findings from plants which can be considered valuable for the development of new drugs against malignant cells and infective diseases. Interest in anti-infective agents is increasing due to the resistance of microorganisms to existing drugs and newly emerging infectious diseases. This resistance is also, nowadays, associated to some forms of cancers. In addition, the value of plants as essential part in the health care pipeline in low- and middle-income countries is under consideration even though these countries are almost all surrounded by a rich and untapped biodiversity. People are always relying on “modern drugs and treatment” which is unfortunately not affordable to all. Therefore, the present compilation of data on plant-derived compounds can inspire the formulation of ameliorated traditional medicines (ATM) against the targeted diseases and the conservation of species.

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Carvacrol and thymol components inhibiting Pseudomonas aeruginosa adherence and biofilm formation

Cited by 54 publications

References 33 publications

Antimicrobial Activity of Naturally Occurring Phenols and Derivatives Against Biofilm and Planktonic Bacteria

Antimicrobial Activity of Naturally Occurring Phenols and Derivatives Against Biofilm and Planktonic Bacteria

Strategies for Interfering With Bacterial Early Stage Biofilms

Plant-Derived Compounds against Microbial Infections and Cancers

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