Carvacrol inhibits atherosclerotic neointima formation by downregulating reactive oxygen species production in vascular smooth muscle cells

High Levels of Soluble Endoglin Induce a Proinflammatory and Oxidative-Stress Phenotype Associated with Preserved NO-Dependent Vasodilatation in Aortas from Mice Fed a High-Fat Diet

“…Since NOXs represent enzymes producing primarily ROS and NOX-1 and NOX-2 are present in endothelial cells [27] and in vascular smooth muscle cells [28,29,30], we propose that high levels of human plasma sEng in mice fed a high-fat diet induce oxidative stress in the aortic wall.…”

Redox signaling in cardiovascular pathophysiology: A focus on hydrogen peroxide and vascular smooth muscle cells

“…In VSMC, Nox1, Nox2, and Nox4 have been linked to multiple cardiovascular diseases, including hypertension, atherosclerosis, and diabetic vasculopathy [42], [43], [44], [45]. Nox1 is primarily found in caveolae, endosomes, and plasma membranes of VSMC [46] and it has a critical role in VSMC proliferation in response to angiotensin II (Ang II), PDGF, and thrombin [47], [48], [49]. Nox1-deficiency inhibited injury-induced neointimal formation, which was associated with inhibition of VSMC proliferation and migration [50].…”

Synthesis and antioxidant property of novel 1,2,3-triazole-linked starch derivatives via ‘click chemistry’

“…•− ) [1][2][3], can induce damage to cellular constituents [4], which can cause neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, cancer, hypertension, diabetes, and many other diseases associated with aging in biological systems [5][6][7][8][9]. The role of antioxidants has received increased attention during the past decades.…”