Carvacrol partially reverses symptoms of diabetes in STZ-induced diabetic rats

Abstract

Little is known about the protective effects of carvacrol on the symptoms of streptozotocin induced diabetes in rats. Hence, this present study was designed to evaluate the protective effect of the strong antioxidant, carvacrol, on the symptoms of streptozotocin induced diabetes in rats. Carvacrol at the doses of 25 and 50 mg/kg body weight were orally administered to diabetic rats for a period of 7 days after the onset of diabetes. Food-water intake and body weight changes were daily recorded. Biochemical parameters such as serum glucose, insulin, total cholesterol, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase were measured. Although treatment of diabetic rats with oral administration of carvacrol resulted in a slight reduction in serum glucose level and significant reduction in serum total cholesterol, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase in comparison with diabetic control rats, there were no significant differences in serum insulin levels, food-water intake values and body weight changes. Despite the inadequacy of carvacrol on diabetes treatments, it was determined to have at least a partially protective role on liver enzymes.

Essential oil ofZygophyllum albuminhibits key-digestive enzymes related to diabetes and hypertension and attenuates symptoms of diarrhea in alloxan-induced diabetic rats

“…The hypoglycemic effect observed may be attributed to the presence of monoterpenic phenols such as carvacrol (Deng et al, 2013;Ezhumalai et al, 2014) and/or eugenol in the essential oil (Mnafgui et al, 2013a,b;Nangle et al, 2006;Srinivasan et al, 2014). The hypoglycemic effect of carvacrol, which is the major compound identified in the studied plant, was previously demonstrated to partially reverse symptoms of diabetes in streptozotocin-induced diabetic rats (Bayramoglu et al, 2013). The previous study indicated that despite its hypoglycemic potential, carvacrol could not have insulin-mimetic properties or be capable to induce insulin production from the surviving beta cells.…”

Carvacrol modulates oxidative stress and decreases cell injury in pancreas of rats with acute pancreatitis

“…Monoterpenes are obtained from essential oils and many of them have shown antioxidant activity. Carvacrol (CAR) used as the most active constituent of thyme EOs is a predominant monoterpenoic phenol and exhibits a potent anti-fungal, anti-viral, anti-tumor, antidiabetic and anti-inflammatory effect (Bayramoglu et al 2014). It is also recognized as a safe food additive and used as flavoring agent in packed foods, sweets, beverages, and chewing gum (Abdollahi et al 2012;Gilling et al 2014).…”

Ergosterol Alleviates Kidney Injury in Streptozotocin-Induced Diabetic Mice

“…Glucose in diabetic mice fails to convert to carbohydrates due to the lack of insulin. However, massive accumulation of glucose metabolizes to fatty acids in liver [ 24 ]. The overproduction of serum fatty acids by STZ-induced diabetics facilitates the conversion of excessive fatty acids into phospholipids and cholesterol in liver [ 22 ].…”