Carvacrol presynaptically enhances spontaneous excitatory transmission and produces outward current in adult rat spinal substantia gelatinosa neurons

Qin, Luo; Fujita, Teizo; Jiang, Changyu; Kumamoto, Eiichi

doi:10.1016/j.brainres.2014.10.021

Cited by 16 publications

(11 citation statements)

References 59 publications

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“…Camphor and carvone, which is a major compound in spearmint essential oil, can also activate TRPV1 and TRPA1 channels 37 . Borneol, one of major constituents of rosemary oil, inhibited TRPA1 mediated cationic currents 38 , whereas carvacrol, which is abundant in oregano oil, activated TRPA1 but not TRPV1 channels 39 . Finally, menthol, one of major constituents of peppermint essential oil, is a ligand of TRPM8 channels 40 .…”

Section: Discussionmentioning

confidence: 99%

Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents

Schepetkin

Кушнаренко

Özek

et al. 2016

J. Agric. Food Chem.

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Essential oils were obtained by hydrodistillation of the umbels+seeds and stems of Ferula akitschkensis (FAEOu/s and FAEOstm, respectively) and analyzed by gas chromatography and gas chromatography–mass spectrometry. Fifty two compounds were identified in FAEOu/s. The primary components were sabinene, α-pinene, β-pinene, terpinen-4-ol, eremophilene, and 2-himachalen-7-ol, while the primary components of FAEOstm were myristicin and geranylacetone. FAEOu/s, β-pinene, sabinene, γ-terpinene, geranylacetone, isobornyl acetate, and (E)-2-nonenal stimulated [Ca2]i mobilization in human neutrophils, with the most potent being geranylacetone (EC50 = 7.6 ± 1.9 µM) and isobornyl acetate 6.4 ± 1.7 (EC50 = 7.6 ± 1.9 µM). In addition, treatment of neutrophils with β-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate desensitized the cells to N-formyl-Met-Leu-Phe (fMLF)- and interleukin-8 (IL-8)-induced [Ca2]i flux and inhibited fMLF-induced chemotaxis. The effects of β-pinene, sabinene, γ-terpinene, geranylacetone, and isobornyl acetate on neutrophil [Ca2+]i flux were inhibited by transient receptor potential (TRP) channel blockers. Furthermore, the most potent compound, geranylacetone, activated Ca2+ influx in TRPV1-transfected HEK293 cells. In contrast, myristicin inhibited neutrophil [Ca2+]i flux stimulated by fMLF and IL-8 and inhibited capsaicin-induced Ca2+ influx in TRPV1-transfected HEK293 cells. These findings, as well as pharmacophore modeling of TRP agonists, suggest that geranylacetone is a TRPV1 agonist, whereas myristicin is a TRPV1 antagonist. Thus, at least part of the medicinal properties of Ferula essential oils may be due to modulatory effects on TRP channels.

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Section: Discussionmentioning

confidence: 99%

Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents

Schepetkin

Кушнаренко

Özek

et al. 2016

J. Agric. Food Chem.

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“…We found out that (þ)-carvone has an ability to activate TRPA1 channels. The EC 50 value (0.72 mM) for this activation was similar to that of carvacrol (0.69 mM; [10]) while being somewhat smaller than those of eugenol and zingerone (3.8 mM and 1.3 mM, respectively; [8,13]). It is well-known that there is a difference in actions on voltage-gated ion channels and neurotransmitter receptors among stereoisomers (see Refs.…”

Section: Discussionmentioning

confidence: 80%

“…Slice preparations from the adult rat spinal cord were prepared as described elsewhere [4,10,13]. Briefly, male SpragueeDawley rats (6e8 weeks old) were anesthetized with urethane (1.2 g/kg, i.p.…”

Section: Methodsmentioning

confidence: 99%

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Spontaneous l-glutamate release enhancement in rat substantia gelatinosa neurons by (−)-carvone and (+)-carvone which activate different types of TRP channel

Kang

Jiang

Fujita

et al. 2015

Biochemical and Biophysical Research Communications

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“…The hippocampus is known to play important roles in learning and memory [11][12][13]. Spontaneous excitatory postsynaptic current (sEPSC) is a physiological characteristic of the hippocampus, an important phenomenon believed to contribute to learning and memory processes within the hippocampus [26]. Following presynaptic stimulation, the physiological characteristics of the evoked sEPSC become transformed, which may suggest an influence of sEPSC on synaptic transmissions within the hippocampus.…”

Section: Introductionmentioning

confidence: 99%

Patch-clamp recordings of thermal effects of magnetic stimulation on the physiological characteristic of rat hippocampal neurons

Dong

Kong

et al. 2016

ARCH BIOL SCI BELGRA

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Transcranial magnetic stimulation (TMS) has proven to be an invaluable tool both in clinical practice and basic brain research. However, many concomitant effects of TMS are still incompletely understood, including thermal effects induced by TMS. The present study investigated how thermal effects induced by magnetic stimulation influence the properties of the spontaneous excitatory postsynaptic current (sEPSC) of hippocampal CA1 pyramidal neurons. We have demonstrated that a 50-Hz low-frequency electromagnetic field with intensities of 7, 14, and 23 mT can induce thermal heating in artificial cerebrospinal fluid (aCSF) from 25 to 40°C over a period of 15 min. We also report that the thermal effects induced by TMS directly influence the properties of sEPSC in hippocampal CA1 pyramidal neurons. Double measures were taken to control the temperature across experiments in order to ensure the accuracy of the temperature measurement of the aCSF. These novel findings provide important insight into the thermal effects induced by TMS as well as their consequences.

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Carvacrol presynaptically enhances spontaneous excitatory transmission and produces outward current in adult rat spinal substantia gelatinosa neurons

Cited by 16 publications

References 59 publications

Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents

Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents

Spontaneous l-glutamate release enhancement in rat substantia gelatinosa neurons by (−)-carvone and (+)-carvone which activate different types of TRP channel

Patch-clamp recordings of thermal effects of magnetic stimulation on the physiological characteristic of rat hippocampal neurons

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