Carvacrol prevents D-( +)-galactose-induced aging-associated erectile dysfunction by improving endothelial dysfunction and oxidative stress in rats

de Almeida Feitosa, Mathania Silva; de Almeida, Arthur José Pontes Oliveira; Dantas, Sabine Helena; de Lourdes Assunção Araújo de Azeve, Fátima; de Souza Júnior, Javanyr Frederico; Gonçalves, Tays Amanda Felisberto; de Lima Silva, Sonaly; Soares, Evyllen Myllena Cardoso; Alves, Hayaly Felinto; Lima, Thais Trajano; da Silva Pontes, Larisse Virgolino; Guerra, Ricardo Romão; Araújo, Islania Giselia Albuquerque; de Medeiros, Isac Almeida

doi:10.1007/s00210-024-03264-8

Naunyn-Schmiedeberg's Arch Pharmacol

2024

DOI: 10.1007/s00210-024-03264-8

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Carvacrol prevents D-( +)-galactose-induced aging-associated erectile dysfunction by improving endothelial dysfunction and oxidative stress in rats

Mathania Silva de Almeida Feitosa,

Arthur José Pontes Oliveira de Almeida,

Sabine Helena Dantas

et al.

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Association between composite dietary antioxidant index and erectile dysfunction: a cross-sectional study from NHANES

Hao,

Chen,

Ren

et al. 2024

BMC Public Health

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Background Individual antioxidants may not fully capture the comprehensive antioxidant intake from an individual's diet. This study utilizes the Complex Dietary Antioxidant Index (CDAI) to evaluate the combined effects of various dietary antioxidants in the diet. The goal is to investigate the relationship between CDAI and the incidence of erectile dysfunction (ED), offering insights for dietary guidelines and intervention strategies aimed at mitigating the burden of ED.Methods This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) database in the years 2001-2004. We employed a weighted multivariate logistic regression model to validate the relationship between CDAI and ED. Subgroup analyses were conducted to explore the correlation between CDAI and ED across different subgroups. Additionally, we used propensity score matching (PSM) to adjust for several key confounding variables, enhancing the robustness of the results. ResultsIn the fully adjusted multivariate logistic regression model for confounding variables, CDAI is negatively correlated with the risk of ED (OR = 0.95, 95% CI: 0.92-0.99, P = 0.005). When CDAI is transformed into a categorical variable based on quartiles, Q3 (OR = 0.73, 95% CI: 0.53-0.99, P = 0.040) and Q4 (OR = 0.70, 95% CI: 0.51-0.96, P = 0.026) show a negative correlation with the risk of ED. Subgroup analysis reveals no significant interaction. After adjusting for major confounding variables through PSM, the association between CDAI and reduced risk of ED remains significant. ConclusionIn our study cohort, there is an association between CDAI and a reduced risk of ED, and further research is needed to validate and refine this conclusion.

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Association between composite dietary antioxidant index and erectile dysfunction: a cross-sectional study from NHANES

Hao,

Chen,

Ren

et al. 2024

BMC Public Health

View full text Add to dashboard Cite

show abstract

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Carvacrol prevents D-( +)-galactose-induced aging-associated erectile dysfunction by improving endothelial dysfunction and oxidative stress in rats

Cited by 1 publication

References 61 publications

Association between composite dietary antioxidant index and erectile dysfunction: a cross-sectional study from NHANES

Association between composite dietary antioxidant index and erectile dysfunction: a cross-sectional study from NHANES

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