Carvedilol improves left ventricular function and symptoms in chronic heart failure: A double-blind randomized study

Abstract

Long-term carvedilol therapy improves rest cardiac function and lessens symptoms in patients with heart failure.

Prospective, Randomized Comparison of Effect of Long-Term Treatment With Metoprolol or Carvedilol on Symptoms, Exercise, Ejection Fraction, and Oxidative Stress in Heart Failure

“…Furthermore, hemodynamic studies with carvedilol show diminution of its vasodilating effects during long-term use. [3][4][5] Thus, the long-term benefit of ␣-blockade in heart failure has yet to be demonstrated.…”

“…[1][2][3][4][5][6][7][8][9] One of the earliest and most frequently studied ␤-blockers in a heart failure population is metoprolol, a second-generation ␤ 1 -selective agent without specific vasodilating properties. Carvedilol is a third-generation ␤-blocker that combines nonselective ␤-blockade, ␣-blockade, and antioxidant effects.…”

Ecocardiografia e teste de caminhada de 6 minutos na disfunção sistólica do ventrículo esquerdo

“…after a follow-up in patients with LV systolic dysfunction that received ACE-inhibitors 39,40 , new-generation beta-blockers [18][19][20][21][22] , and underwent exercise training 23 .…”

“…It is considered to be realistically related to daily physical activity. Consequently, it has been incorporated into studies of assessment of exercise capacity 12,13 , of quality of life 14 , of efficacy of new therapeutic agents [15][16][17] , including beta-blockers [18][19][20][21][22] , of physical training programs 23 and of prognostic stratification [24][25][26][27][28][29] .…”

How Do β-Blockers Improve Ventricular Function in Patients With Congestive Heart Failure?

“…1 Treatment of these patients with ␤-adrenergic receptor-blocking drugs reduces morbidity and mortality, 2 improves ventricular function, and reverses pathological remodeling. 3 Clinical and experimental animal studies have suggested a number of mechanisms by which chronic exposure to this class of drugs, which have a negative inotropic effect in normal myocardium, could have an apparently paradoxical beneficial effect in failing myocardium.…”