Carvedilol induces the antiapoptotic proteins Nrf2 and Bcl2 and inhibits cellular apoptosis in aluminum-induced testicular toxicity in male Wistar rats

Ahmed, Soliman; Mohammed, Walaa

doi:10.1016/j.biopha.2021.111594

Cited by 22 publications

(10 citation statements)

References 47 publications

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“…This imbalance could explain the histological and apoptotic changes observed at the light microscope level in our study. This aligns with the findings of Ahmed and Mohammed (2021).…”

Section: Discussionsupporting

confidence: 91%

Endoplasmic reticulum stress and mitochondrial injury are critical molecular drivers of AlCl3-induced testicular and epididymal distortion and dysfunction: protective role of taurine

Khalaf

Elsamanoudy

Abo-Elkhair

et al. 2022

Histochem Cell Biol

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Aluminum, the third most plentiful metal in the Earth’s crust, has potential for human exposure and harm. Oxidative stress plays an essential role in producing male infertility by inducing defects in sperm functions. We aimed to investigate the role of endoplasmic reticulum (ER) stress and mitochondrial injury in the pathogenesis of aluminum chloride (AlCl3)-induced testicular and epididymal damage at the histological, biochemical, and molecular levels, and to assess the potential protective role of taurine. Forty-eight adult male albino rats were separated into four groups (12 in each): negative control, positive control, AlCl3, and AlCl3 plus taurine groups. Testes and epididymis were dissected. Histological and immunohistochemical (Bax and vimentin) studies were carried out. Gene expression of vimentin, PCNA, CHOP, Bcl-2, Bax, and XBP1 were investigated via quantitative real-time polymerase chain reaction (qRT-PCR), besides estimation of malondialdehyde (MDA) and total antioxidant capacity (TAC). Light and electron microscopic examinations of the testes and epididymis revealed pathological changes emphasizing both mitochondrial injury and ER stress in the AlCl3 group. Taurine-treated rats showed a noticeable improvement in the testicular and epididymal ultrastructure. Moreover, they exhibited increased gene expression of vimentin, Bcl-2, and PNCA accompanied by decreased CHOP, Bax, and XBP1 gene expression. In conclusion, male reproductive impairment is a significant hazard associated with AlCl3 exposure. Both ER stress and mitochondrial impairment are critical mechanisms of the deterioration in the testes and epididymis induced by AlCl3, but taurine can amend this.

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“…This imbalance could explain the histological and apoptotic changes observed at the light microscope level in our study. This aligns with the findings of Ahmed and Mohammed (2021).…”

Section: Discussionsupporting

confidence: 91%

Endoplasmic reticulum stress and mitochondrial injury are critical molecular drivers of AlCl3-induced testicular and epididymal distortion and dysfunction: protective role of taurine

Khalaf

Elsamanoudy

Abo-Elkhair

et al. 2022

Histochem Cell Biol

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“…This pathway has antioxidant function due to its vital role in the expression of many genes for antioxidant enzymes such as SOD, glutathione‐s‐transferase (GST), NADPH quinone dehydrogenase-1 (NQO1). In addition, induction of this pathway was found to protect against cellular apoptosis ( Ahmed and Mohammed, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Empagliflozin attenuates neurodegeneration through antioxidant, anti-inflammatory, and modulation of α-synuclein and Parkin levels in rotenone-induced Parkinson’s disease in rats

Ahmed¹,

Elsayed²,

Kandeil³

et al. 2022

Saudi Pharmaceutical Journal

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“…Further studies using other β-adrenergic antagonists, such as atenolol or propranolol, have demonstrated the attenuation of myocardial cell or endothelial cell apoptosis, but these protective effects of the drugs were significantly weaker than those of carvedilol [ 138 , 139 ]. Carvedilol was shown to decrease apoptosis by modulating various pro/antiapoptotic pathways and caspases, in different in vivo and in vitro models [ 142 ]. Indeed, it inhibits proapoptotic pathways, such as the caspase-3 and caspase-9 pathways, thus reducing cell death.…”

Section: New Strategy To Protect Grafts From Ischemia/reperfusion Injurymentioning

confidence: 99%

“…Indeed, it inhibits proapoptotic pathways, such as the caspase-3 and caspase-9 pathways, thus reducing cell death. In addition, it promotes the activation of the antiapoptotic caspase Bcl-2 [ 142 ].…”

Section: New Strategy To Protect Grafts From Ischemia/reperfusion Injurymentioning

confidence: 99%

A Potential Route to Reduce Ischemia/Reperfusion Injury in Organ Preservation

Micó-Carnero

Zaoualí

Rojano-Alfonso

et al. 2022

Cells

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The pathophysiological process of ischemia and reperfusion injury (IRI), an inevitable step in organ transplantation, causes important biochemical and structural changes that can result in serious organ damage. IRI is relevant for early graft dysfunction and graft survival. Today, in a global context of organ shortages, most organs come from extended criteria donors (ECDs), which are more sensitive to IRI. The main objective of organ preservation solutions is to protect against IRI through the application of specific, nonphysiological components, under conditions of no blood or oxygen, and then under conditions of metabolic reduction by hypothermia. The composition of hypothermic solutions includes osmotic and oncotic buffering components, and they are intracellular (rich in potassium) or extracellular (rich in sodium). However, above all, they all contain the same type of components intended to protect against IRI, such as glutathione, adenosine and allopurinol. These components have not changed for more than 30 years, even though our knowledge of IRI, and much of the relevant literature, questions their stability or efficacy. In addition, several pharmacological molecules have been the subjects of preclinical studies to optimize this protection. Among them, trimetazidine, tacrolimus and carvedilol have shown the most benefits. In fact, these drugs are already in clinical use, and it is a question of repositioning them for this novel use, without additional risk. This new strategy of including them would allow us to shift from cold storage solutions to cold preservation solutions including multitarget pharmacological components, offering protection against IRI and thus protecting today’s more vulnerable organs.

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Carvedilol induces the antiapoptotic proteins Nrf2 and Bcl2 and inhibits cellular apoptosis in aluminum-induced testicular toxicity in male Wistar rats

Cited by 22 publications

References 47 publications

Endoplasmic reticulum stress and mitochondrial injury are critical molecular drivers of AlCl3-induced testicular and epididymal distortion and dysfunction: protective role of taurine

Endoplasmic reticulum stress and mitochondrial injury are critical molecular drivers of AlCl3-induced testicular and epididymal distortion and dysfunction: protective role of taurine

Empagliflozin attenuates neurodegeneration through antioxidant, anti-inflammatory, and modulation of α-synuclein and Parkin levels in rotenone-induced Parkinson’s disease in rats

A Potential Route to Reduce Ischemia/Reperfusion Injury in Organ Preservation

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