Carvedilol-Loaded Cubosome Gel to Accelerate Wound Healing

Pandit, Ashlesha P.; Kulkarni, Vinit S.; Mute, Vaishali M.; Kandekar, Ujjwala

doi:10.1007/s12247-023-09766-x

Cited by 2 publications

(2 citation statements)

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“…The indirect method was used for the determination of entrapment efficiency ( Pandit et al, 2023 ). Transfersomal dispersion was placed in centrifugation tubes and centrifuged at 8,000 rpm (C-24 plus, Remi Elektrotechnik Ltd., India) at 4°C for 2 h, followed by decantation of a clear supernatant solution.…”

Section: Methodsmentioning

confidence: 99%

“…From the resulting time plot, cohesiveness (work essential to distort the hydrogel in the downward movement of the probe), hardness (strength obligatory to achieve a specified deformation), and adhesiveness (energy essential to surpass attractive forces among the sample and probe) were read carefully. Spreadability was calculated from the energy required to deform the sample ( Pandit et al, 2023 ).…”

Section: Methodsmentioning

confidence: 99%

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Optimizing fluconazole-embedded transfersomal gel for enhanced antifungal activity and compatibility studies

Cheng,

Kandekar,

et al. 2024

Front. Pharmacol.

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Fungal infections are of major concern all over the globe, and fluconazole is the most prevalently used drug to treat it. The goal of this research work was to formulate a fluconazole-embedded transfersomal gel for the treatment of fungal infections. A compatibility study between fluconazole and soya lecithin was performed by differential scanning calorimetry (DSC). Transfersomes were formulated by a thin-film hydration technique using soya lecithin and Span 80. A central composite design was adopted to prepare different formulations. Soya lecithin and Span 80 were chosen as independent variables, and the effect of these variables was studied on in vitro drug diffusion. Formulations were evaluated for entrapment efficiency and in vitro drug diffusion. The results of in vitro drug diffusion were analyzed using the analysis of variance (ANOVA) test. Optimized formulation was prepared based on the overlay plot and evaluated by scanning electron microscopy, DSC, vesicle size, polydispersity index (PDI), zeta potential, and in vitro drug diffusion studies. An optimized formulation was loaded into xanthan gum gel base and evaluated for pH, viscosity, in vitro and ex vivo drug diffusion, and antifungal activity. DSC studies revealed compatibility between fluconazole and soya lecithin. Entrapment efficiency and in vitro drug diffusion of various formulations ranged between 89.92% ± 0.20% to 97.28% ± 0.42% and 64% ± 1.56% to 85% ± 2.05%, respectively. A positive correlation was observed between in vitro drug diffusion and Span 80; conversely, a negative correlation was noted with soya lecithin. Entrapment efficiency, particle size, zeta potential, PDI, and drug diffusion of optimized formulation were 95.0% ± 2.2%, 397 ± 2 nm, −38 ± 5 mV, 0.43%, and 81 % ± 2%, respectively. SEM images showed well-distributed spherical-shaped transfersomes. In vitro, ex vivo drug diffusion and antifungal studies were conclusive of better diffusion and enhanced antifungal potential fluconazole in transfersomal formulation.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%