Caryocar coriaceum extracts exert leishmanicidal effect acting in promastigote forms by apoptosis-like mechanism and intracellular amastigotes by Nrf2/HO-1/ferritin dependent response and iron depletion

Tomiotto-Pellissier, Fernanda; Alves, Daniela Ribeiro; Miranda-Sapla, Milena Menegazzo; Morais, Selene Maia de; Assolini, João Paulo; Bortoleti, Bruna Taciane da Silva; Gonçalves, Manoela Daiele; Cataneo, Allan Henrique Depieri; Kian, Danielle; Madeira, Tiago Bervelieri; Yamauchi, Lucy Megumi; Nixdorf, Suzana Lucy; Costa, Idessânia Nazareth; Conchon‐Costa, Ivete; Pavanelli, Wander Rogério

doi:10.1016/j.biopha.2017.12.083

Cited by 59 publications

(33 citation statements)

References 40 publications

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“…HO-1 can metabolize heme to biliverdin, iron, and CO (Kweider et al, 2013). Although many studies have confirmed that Nrf2-HO-1 pathway can regulate intracellular iron concentration (LIP) (Chillappagari et al, 2014;Tomiotto-Pellissier et al, 2018;Cataneo et al, 2019;Selvakumar et al, 2019), there is still no direct evidence to prove our hypothesis that intracellular iron concentration is mainly regulated by the Nrf2-HO-1 pathway. Further research is needed to confirm this hypothesis.…”

Section: Research Progress Of Nuclear Factor E2 Related Factor 2 On Fmentioning

confidence: 72%

Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases

2020

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Section: Research Progress Of Nuclear Factor E2 Related Factor 2 On Fmentioning

confidence: 72%

Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases

2020

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“…In addition to these effects, there are reports of the leishmanicidal effect of the fruit. Therefore, the search for alternative treatments, including the use of natural products with less toxicity than conventional treatments, has become more frequent [17].…”

Section: Biological Activitiesmentioning

confidence: 99%

“…The study by Tomiotto-Pellissier [17] aimed to verify the leishmanicidal action of C. coriaceum leaf extracts obtained from extraction by EAC and methanol (MET). The extracts were able to induce the parasite mitochondria membrane depolarization in the promastigote phase; such membrane is crucial for parasite survival, since Leishmania spp.…”

Section: Biological Activitiesmentioning

confidence: 99%

Brazilian Amazon Plants: An Overview of Chemical Composition and Biological Activity

Cunha¹,

Domingues²,

Ambrósio³

et al. 2021

Natural Resources Management and Biological Sciences

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Currently, the number of diseases has been increasing and reaching the population directly, and the deliberate use of drugs is creating resistance of pathogens in several drugs, a fact evidenced by the increased ineffectiveness of drugs and the persistence of infections in the body. Given this, it is necessary to search for new alternative drugs that can effectively promote effective therapy. It is possible to highlight, in Brazil, the diversity of the Amazonian flora, which has several species with considerable potential as a source of new molecules with identified biological activity. Thus, a literature review study was conducted in order to describe the applications of some Amazonian extracts and their chemical characteristics and biological activity. The Amazon rain forest has considerable diversity of plant species with biological properties that may be useful to public health. Further research is needed to identify new compounds with health benefits.

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“…Miltefosine has direct activity against L. donovani but also contributes to host response against infection in a mechanism that involves HO-1 inhibition [113]. Interestingly, recent studies demonstrated that treatment with plant extracts-precursors of flavonoids or purified flavonoids presenting anti-leishmanicidal activity in promastigotes and amastigotes of L. amazonensis and L. brasiliensis-induce NRF2, HO-1, and FtH expression, reducing the labile iron pool of infected macrophages [114][115][116]. The authors attribute the reduction on macrophage infection by these plant products in part to the depletion of available iron.…”

Section: Ho-1 In Leishmaniasismentioning

confidence: 99%

Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance

et al. 2020

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Heme oxygenase (HO-1) mediates the enzymatic cleavage of heme, a molecule with proinflammatory and prooxidant properties. HO-1 activity deeply impacts host capacity to tolerate infection through reduction of tissue damage or affecting resistance, the ability of the host to control pathogen loads. In this Review, we will discuss the contribution of HO-1 in different and complex protozoan infections, such as malaria, leishmaniasis, Chagas disease, and toxoplasmosis. The complexity of these infections and the pleiotropic effects of HO-1 constitute an interesting area of study and an opportunity for drug development.

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Caryocar coriaceum extracts exert leishmanicidal effect acting in promastigote forms by apoptosis-like mechanism and intracellular amastigotes by Nrf2/HO-1/ferritin dependent response and iron depletion

Cited by 59 publications

References 40 publications

Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases

Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases

Brazilian Amazon Plants: An Overview of Chemical Composition and Biological Activity

Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance

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