Cascade controlled release system based on pH-responsive ZIF-8 capsule and enzyme-responsive hyaluronic acid hydrogel for tumor marker detection using electro-readout-mode

Yao, Tao; Feng, Jiejie; Chu, Changshun; Ma, Zhanfang; Han, Hongliang

doi:10.1016/j.snb.2021.130701

Cited by 21 publications

(11 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Zeolitic imidazolate framework-8 (ZIF-8) has attracted extensive attention due to natural degradability and good biocompatibility. , ZIF-8 is constructed by Zn ions (Zn 2+ ) and 2-methylimidazole . After injection, Zn 2+ released from ZIF-8 as a trace element in the human body kills bacteria without threatening normal cells. − Moreover, ZIF-8 is characterized by pH-responsive degradation, which releases higher levels of Zn 2+ at the infection site, thus increasing antibacterial efficiency. , Graphene oxide (GO) nanosheets have excellent biocompatibility and strong NIR laser absorption at 808 nm and are considered potential photothermal agents. , Assuming that ZIF-8 and GO are incorporated into the bone scaffolds, they are expected to endow the scaffolds with efficient and safe antibacterial properties for chemo-photothermal therapy.…”

Section: Introductionmentioning

confidence: 99%

“…21−23 Moreover, ZIF-8 is characterized by pH-responsive degradation, which releases higher levels of Zn 2+ at the infection site, thus increasing antibacterial efficiency. 24,25 Graphene oxide (GO) nanosheets have excellent biocompatibility and strong NIR laser absorption at 808 nm and are considered potential photothermal agents. 26,27 Assuming that ZIF-8 and GO are incorporated into the bone scaffolds, they are expected to endow the scaffolds with efficient and safe antibacterial properties for chemo-photothermal therapy.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In Situ Growth of a Metal–Organic Framework on Graphene Oxide for the Chemo-Photothermal Therapy of Bacterial Infection in Bone Repair

Yang

Zan

Shuai

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Bacterial infection with high morbidity (>30%) seriously affects the defect’s healing after bone transplantation. To this end, chemotherapy and photothermal therapy have been utilized for antibacterial treatment owing to their high selectivity and minimal toxicity. However, they also face several dilemmas. For example, bacterial biofilms prevented the penetration of antibacterial agents and local temperatures (over 70 °C) caused by the photothermal therapy damaged normal tissue. Herein, a co-dispersion nanosystem with chemo-photothermal function was constructed via the in situ growth of zeolitic imidazolate framework-8 (ZIF-8) on graphene oxide (GO) nanosheets. In this nanosystem, GO generates a local temperature (∼50 °C) to increase the permeability of a bacterial biofilm under near-infrared laser irradiation. Then, Zn ions released by ZIF-8 seized this chance to react with the bacterial membrane and inactivate it, thus realizing efficient sterilization in a low-temperature environment. This antibacterial system was incorporated into a poly-l-lactic acid scaffold for bone repair. Results showed that the scaffold showed a high antibacterial rate of 85% against both Escherichia coli and Staphylococcus aureus. In vitro cell tests showed that the scaffold promoted cell proliferation.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Situ Growth of a Metal–Organic Framework on Graphene Oxide for the Chemo-Photothermal Therapy of Bacterial Infection in Bone Repair

Yang

Zan

Shuai

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…An acidic pH can cause the collapse of the ZIF-8 structure. 38,39 In addition, the effect of the AA2P substrate and ALP on the SERS intensity was investigated. As shown in Figure 3B, the SERS intensity of PAZ NPs incubated with AA and AA2P was not significantly changed, indicating that AA and the phosphate group in AA2P cannot decompose ZIF-8 and trigger the release of PATP-Au NPs.…”

Section: Control Of Zif-8 Collapse and Patp-au Np Release By Alpmentioning

confidence: 99%

A Strategy for the Determination of Alkaline Phosphatase Based on the Self-Triggered Degradation of Metal–Organic Frameworks by Phosphate

Wang

Liu

et al. 2023

Anal. Chem.

View full text Add to dashboard Cite

Alkaline phosphatase (ALP) is widely present in the human body and is an important biomarker. Numerous ALP detection studies have been carried out, and ascorbic acid (AA) is often used as the reducing component in the sensors to monitor ALP levels since it can be produced from ascorbic acid 2-phosphate (AA2P) hydrolysis in the presence of ALP. However, it is well-known that AA is a strong reducing agent and can be easily oxidized. The disproportion between oxidized AA and reduced AA reactions results in the generation of AA free radicals with single electrons that may lead to inaccurate results in assays. To solve this problem, we synthesized a core−shell metal−organic framework sensor (PATP-Au@ZIF-8 NP) and used it as a sensitive and accurate ALP detection sensor with self-triggered control of phosphate ions (Pi) to avoid the potential inaccuracy of the method that uses AA as the reducing component. By establishing a physical shell on the surface of the gold nanoparticles (Au NPs), the sensor not only can eliminate the random assembly of metal nanoparticles caused by plasma exposure but also can generate self-triggering of Pi caused by ALP. Pi can decompose ZIF-8 through coordination with Zn 2+ and thus can destroy the ZIF-8 shell structure of the prepared PAZ NPs. Au NPs are released and then become aggregated, in turn causing the SERS "hot spot" area to increase. The enhancement of the SERS signals was found to be directly associated with the level of Pi released from ALP-triggered hydrolysis. The response of the strategy was linear at ALP concentrations ranging from 0.1 to 150 mU/mL (r = 0.996) with a detection limit of 0.03 mU/mL. Lastly, the developed strategy was employed in the evaluation of ALP inhibitors, and the possibility to implement the developed SERS strategy for rapid and selective analysis of ALP in human serum was demonstrated.

show abstract

“…Due to the mild synthetic conditions, ZIF-8 can encapsulate drug molecules or biomolecules such as proteins and nucleic acids in situ during the synthesis [93]. It also shows pH-responsive property, enabling on-demand release of cargo molecules and zinc ions (Zn 2+ ) in acidic tumoral and intracellular environment [94][95][96].…”

Section: Direct Regulation Aiming At Glucose Starvation and Lactate A...mentioning

confidence: 99%

Harnessing bioactive nanomaterials in modulating tumor glycolysis-associated metabolism

2022

J Nanobiotechnol

View full text Add to dashboard Cite

Glycolytic reprogramming is emerging as a hallmark of various cancers and a promising therapeutic target. Nanotechnology is revolutionizing the anti-tumor therapeutic approaches associated with glycolysis. Finely controlled chemical composition and nanostructure provide nanomaterials unique advantages, enabling an excellent platform for integrated drug delivery, biochemical modulation and combination therapy. Recent studies have shown promising potential of nanotherapeutic strategies in modulating tumor glycolytic metabolism alone or in combination with other treatments such as chemotherapy, radiotherapy and immunotherapy. To foster more innovation in this cutting-edge and interdisciplinary field, this review summarizes recent understandings of the origin and development of tumor glycolysis, then provides the latest advances in how nanomaterials modulate tumor glycolysis-related metabolism. The interplay of nanochemistry, metabolism and immunity is highlighted. Ultimately, the challenges and opportunities are presented.

show abstract

Cascade controlled release system based on pH-responsive ZIF-8 capsule and enzyme-responsive hyaluronic acid hydrogel for tumor marker detection using electro-readout-mode

Cited by 21 publications

References 35 publications

In Situ Growth of a Metal–Organic Framework on Graphene Oxide for the Chemo-Photothermal Therapy of Bacterial Infection in Bone Repair

In Situ Growth of a Metal–Organic Framework on Graphene Oxide for the Chemo-Photothermal Therapy of Bacterial Infection in Bone Repair

A Strategy for the Determination of Alkaline Phosphatase Based on the Self-Triggered Degradation of Metal–Organic Frameworks by Phosphate

Harnessing bioactive nanomaterials in modulating tumor glycolysis-associated metabolism

Contact Info

Product

Resources

About