Cascade enantioselective synthesis of γ-aryl-γ-butyrolactones with a delayed stereoselective step

Chiral Heterocycle-Based Receptors for Enantioselective Recognition

“…The tripodal receptors with two phenylglycinol-derived oxazolines displayed significant enantioselectivity for racemic α-chiral ammonium ions (Table 23, entries [1][2][3][4][5][6][7][8]. It was revealed that the changing receptor's symmetry, from C 3 to C 1 , causes intense improvement in the binding mode and chiral recognition.…”

“…Various biological phenomena such as enzyme-substrate, antibody-antigen and drug-biomolecule interactions are a manifestation of the importance of enantiospecific supramolecular processes in living organisms [4]. The importance of chirality in the fields of medicine [5,6], asymmetric synthesis, [7,8] catalysis [9], flavor [10], fragrances [11], biochemistry [12] and material science chemistry [13] has already been well established. While the area of asymmetric synthesis has witnessed a tremendous growth, the practicality of preparing homochiral compounds still remains a challenge.Thus, the stimulus for interest in the separation of racemic mixtures exploiting host-guest chemistry has gained popularity over the years.…”

Development of cyclodextrin stationary phases via 'click' chemistry for chiral capillary electrochromatography and high performance liquid chromatography

“…Generally, two strategies can be considered for the purpose of obtaining optically pure materials: direct enantioselective syntheses (asymmetry synthesis) and enantioseparation of racemic mixtures. Ideally, the desired pure enantiomer could be obtained by direct asymmetry synthesis without further treatment [16][17][18][19][20][21].…”