2022
DOI: 10.1021/acs.joc.2c02375
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Cascade Ring-Opening/Cyclization Reaction of Spiro(nitrocyclopropane)oxindoles with Huisgen Zwitterions and Synthesis of Pyrazolo[3,4-b]indoles

Abstract: Herein, we report a ring-opening/cyclization cascade reaction of spiro(nitrocyclopropane)oxindoles with in situ generated Huisgen zwitterions (HZs) from PPh 3 and azodicarboxylates. This reaction provides an array of polyfunctionalized pyrazolo [3,4-b]indole derivatives in moderate-to-excellent yields and generally high stereoselectivities with a broad substrate scope. The annulation products obtained from di-tert-butyl azodicarboxylates can be readily transformed into aromaticsubstituted pyrazolo [3,4-b]indol… Show more

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Cited by 2 publications
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