Cascade<sup>®</sup> Autologous System Platelet-Rich Fibrin Matrix in the Treatment of Chronic Leg Ulcers

O’Connell, Sean M.; Hessler, Karen; Dardik, Herbert

doi:10.1089/wound.2011.0290

Cited by 17 publications

(19 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased concentration of platelets also yields an increase in the concentration of GFs stored in the α -granules of platelets. 19,20 Currently, several methods are available for PRP preparation, most producing a liquid end product. PRP is clinically used in liquid or gel form to promote tissue repair.…”

Section: Methodsmentioning

confidence: 99%

“…However, this method leads to a clot with high concentrations of red and white blood cells and is associated with an almost total platelet activation, degranulation, and GF release. 19,20 …”

Section: Methodsmentioning

confidence: 99%

“…Instead of producing a PC and platelet-poor plasma, as in conventional PRP systems, a thixotropic separator gel is employed in a low-speed (1100 g ) radial (swing bucket) centrifugation to rapidly isolate both the platelets and fibrinogen-containing plasma from the packed red and white cell fraction. In vitro studies 19–23 demonstrated that platelets isolated from blood using the PRFM membrane are essentially intact and inactivate (cluster designation 62p, a membrane-associated glycoprotein expressed by activated platelets expression <5%). In contrast, 5-minute exposure to 100 U/ml bovine thrombin resulted in >95% activation and >65% degranulation of exposed platelets.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Reconstruction of Alar Nasal Cartilage Defects Using a Tissue Engineering Technique Based on a Combined Use of Autologous Chondrocyte Micrografts and Platelet-rich Plasma: Preliminary Clinical and Instrumental Evaluation

Gentile

Scioli²,

Bielli

et al. 2016

Plastic and Reconstructive Surgery - Global Open

View full text Add to dashboard Cite

Background:Developing cartilage constructs with injectability, appropriate matrix composition, and persistent cartilaginous phenotype remains an enduring challenge in cartilage repair. The combined use of autologous chondrocyte micrografts and platelet-rich plasma (PRP) is an alternative that opens a new era in this field.Methods:At the Department of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Italy, 11 patients underwent nasal alar reconstruction with chondrocyte micrografts gently poured onto PRP in solid form. A computed tomographic scan control was performed after 12 months. Pearson’s Chi-square test was used to investigate difference in cartilage density between native and newly formed cartilages.Results:The constructs of chondrocyte micrografts–PRP that were subcutaneously injected resulted in a persistent cartilage tissue with appropriate morphology, adequate central nutritional perfusion without central necrosis or ossification, and further augmented nasal dorsum without obvious contraction and deformation.Conclusion:This report demonstrated that chondrocyte micrografts derived from nasal septum poured onto PRP in solid form are useful for cartilage regeneration in patients with external nasal valve collapse.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Reconstruction of Alar Nasal Cartilage Defects Using a Tissue Engineering Technique Based on a Combined Use of Autologous Chondrocyte Micrografts and Platelet-rich Plasma: Preliminary Clinical and Instrumental Evaluation

Gentile

Scioli²,

Bielli

et al. 2016

Plastic and Reconstructive Surgery - Global Open

View full text Add to dashboard Cite

show abstract

“…[12] Hence, we studied a series of nine cases showing the usage of autologous PRFM in non-healing chronic trophic ulcers in patients with Hansen's disease.…”

Section: Introductionmentioning

confidence: 99%

Autologous platelet-rich fibrin matrix in non-healing trophic ulcers in patients with Hansen's disease

Nagaraju¹,

Sundar²,

Agarwal³

et al. 2017

J Cutan Aesthet Surg

View full text Add to dashboard Cite

Background:Non-healing trophic ulcers in Hansen's disease patients is one of the major causes for disability. It has been shown that autologous platelet-rich fibrin matrix (PRFM) is effective in healing chronic non-healing leg ulcers.Aim:The objective of this study is to demonstrate the efficacy of autologous platelet-rich fibrin matrix (PRFM) in non-healing trophic ulcers in patients treated for Hansen's disease.Design:A prospective study.Setting:An institution-based clinic.Participants:Seven treated patients with Hansen's disease, with a mean age of 38.33 years, with nine non-healing trophic ulcer of more than 6 weeks duration.Measurements:Photographs were taken before treatment and at every subsequent sitting. Area and volume were calculated at baseline and every subsequent sitting till the closure was achieved.Materials and Methods:The healthy ulcers were treated with PRFM at weekly intervals, repeated once a week for a maximum of five sittings as per requirement.Results:The mean percentage improvement in the area was 93.52%, and volume was 97.74% at the end of the second sitting. All ulcers closed by a maximum of five sittings. No adverse events were noted.Conclusion:PRFM for the treatment of trophic ulcers in treated patients with Hansen's disease is a feasible, safe, simple and inexpensive method.

show abstract

“…The literature searched in MEDLINE by using the MESH term, restricted to human reports and without restrictions to dates or types of study, identified 14 articles [ Table 1]. Of these, five were selected by title, which fulfilled the objective of the present study, but only three were relevant to our study [9,14,15] . Analysis of abstracts from 12 articles, showed that management of venous ulcers were performed with different products, such as platelet-derived, platelet-enriched plasma or non-fibrin matrices.…”

Section: Resultsmentioning

confidence: 99%

A systematic literature review of the management of chronic venous ulcers with autologous fibrin matrix with or without growth factors

Botero¹,

Ardila²,

Borja³

et al. 2018

PAR

View full text Add to dashboard Cite

Aim: To evaluate available evidence for the effective management of venous leg ulcers with fibrin matrix with or without growth factors. Methods: A systematic review of the literature was performed to evaluate the use of fibrin matrices with or without growth factors for the management of chronic venous ulcers in lower limbs. Article searches were performed in MEDLINE, EMBASE, COCHRANE, LILACS and ongoing clinical trials at ClinicalTrial.gov. Results: The search in MEDLINE and EMBASE identified three articles; one was a pilot study evaluating the use of fibrin matrix and autologous growth factors that included patients with chronic ulcers of different etiology. The second article was a description of the product used in the previous study, and the third consisted of a series case reports of patient treated with cultured keratinocytes in a fibrin matrix. A COCHRANE searched resulted in one study assessing the cost effectiveness of using different fibrin matrices. The search in ClinicalTrial.gov and LILACS did not result in any findings. Conclusion: The study did not provide a conclusive evidence for the use of fibrin matrices in patients with venous leg ulcers.

show abstract

Cascade^® Autologous System Platelet-Rich Fibrin Matrix in the Treatment of Chronic Leg Ulcers

Abstract: When treating venous or DFUs, the Cascade system should be used together with standard wound care practice (therapeutic compression for VLU and weight off-loading, debridement, and infection control for DFU) in patients with an adequate blood supply to the lower limb.

Cited by 17 publications

References 7 publications

Reconstruction of Alar Nasal Cartilage Defects Using a Tissue Engineering Technique Based on a Combined Use of Autologous Chondrocyte Micrografts and Platelet-rich Plasma: Preliminary Clinical and Instrumental Evaluation

Reconstruction of Alar Nasal Cartilage Defects Using a Tissue Engineering Technique Based on a Combined Use of Autologous Chondrocyte Micrografts and Platelet-rich Plasma: Preliminary Clinical and Instrumental Evaluation

Autologous platelet-rich fibrin matrix in non-healing trophic ulcers in patients with Hansen's disease

A systematic literature review of the management of chronic venous ulcers with autologous fibrin matrix with or without growth factors

Contact Info

Product

Resources

About

Cascade® Autologous System Platelet-Rich Fibrin Matrix in the Treatment of Chronic Leg Ulcers

Abstract: When treating venous or DFUs, the Cascade system should be used together with standard wound care practice (therapeutic compression for VLU and weight off-loading, debridement, and infection control for DFU) in patients with an adequate blood supply to the lower limb.

Cited by 17 publications

References 7 publications

Reconstruction of Alar Nasal Cartilage Defects Using a Tissue Engineering Technique Based on a Combined Use of Autologous Chondrocyte Micrografts and Platelet-rich Plasma: Preliminary Clinical and Instrumental Evaluation

Reconstruction of Alar Nasal Cartilage Defects Using a Tissue Engineering Technique Based on a Combined Use of Autologous Chondrocyte Micrografts and Platelet-rich Plasma: Preliminary Clinical and Instrumental Evaluation

Autologous platelet-rich fibrin matrix in non-healing trophic ulcers in patients with Hansen's disease

A systematic literature review of the management of chronic venous ulcers with autologous fibrin matrix with or without growth factors

Contact Info

Product

Resources

About

Cascade^® Autologous System Platelet-Rich Fibrin Matrix in the Treatment of Chronic Leg Ulcers