Cascaded elasto-inertial separation of malignant tumor cells from untreated malignant pleural and peritoneal effusions

Abstract

Separation of malignant tumor cells (MTCs) from large background cells in untreated malignant pleural and peritoneal effusions (MPPEs) is critical for improving the sensitivity and efficiency of cytological diagnosis. Herein,...

Biomechanics of circulating cellular and subcellular bioparticles: beyond separation

“…However, these methods are costly and necessitate extensive sample preparation and reagent consumption. In contrast, label-free methods, whether active methods like dielectrophoresis and acoustophoresis [ 10 , 11 ] or passive methods like inertial separation and centrifugation [ 12 – 14 ], exploit the inherent physical, mechanical, and electrical properties of particles for separation. These techniques are typically simpler, quicker, and more cost-effective, making them ideal candidates for point-of-care diagnostics and mitigating biases from antigen affinity and expression levels.…”