Cascading effects of attention disengagement and sensory seeking on social symptoms in a community sample of infants at-risk for a future diagnosis of autism spectrum disorder

Baranek, Grace T.; Woynaroski, Tiffany G.; Nowell, Sallie W.; Turner‐Brown, Lauren; DuBay, Michaela; Crais, Elizabeth R.; Watson, Linda R.

doi:10.1016/j.dcn.2017.08.006

Cited by 95 publications

(99 citation statements)

References 53 publications

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“…Since these developmental precursors likely give rise to the strengths associated with the autism phenotype later in life, eg, heightened perception94 they may be conceptualized as protective factors, but further studies are needed to directly examine how they map on to variable developmental outcomes in individuals. However, as children who develop autism enter their second year of life, they begin to exhibit reduced flexibility in visual attention 959697…”

Section: Trajectories Of Brain Developmentmentioning

confidence: 99%

Linking risk factors and outcomes in autism spectrum disorder: is there evidence for resilience?

Elsabbagh

2020

BMJ

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Autism spectrum disorder (referred to here as autism) is one of several overlapping neurodevelopmental conditions that have variable impacts on different individuals. This variability results from dynamic interactions between biological and non-biological risk factors, which result in increasing differentiation between individuals over time. Although this differentiation continues well into adulthood, the infancy period is when the brain and behavior develop rapidly, and when the first signs and symptoms of autism emerge. This review discusses advances in our understanding of the causal pathways leading to autism and overlapping neurodevelopmental conditions. Research is also mapping trajectories of brain and behavioral development for some risk groups, namely later born siblings of children with autism and/or infants referred because of developmental concerns. This knowledge has been useful in improving early identification and establishing the feasibility of targeted interventions for infant risk groups before symptoms arise. However, key knowledge gaps remain, such as the discovery of protective factors (biological or environmental) that may mitigate the impact of risk. Also, the dynamic mechanisms that underlie the associations between risk factors and outcomes need further research. These include the processes of resilience, which may explain why some individuals at risk for autism achieve better than expected outcomes. Bridging these knowledge gaps would help to provide tools for early identification and intervention that reflect dynamic developmental pathways from risk to outcomes.

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Section: Trajectories Of Brain Developmentmentioning

confidence: 99%

Linking risk factors and outcomes in autism spectrum disorder: is there evidence for resilience?

Elsabbagh

2020

BMJ

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“…Motor disturbances may underlie some of the behavioral core features in autism. The contribution of movements to social cognition and cascade effects on social communication in individuals with autism have been reported (Cook, 2016;Baranek et al, 2018). Notably, therapeutic medicines for motor dysfunction, such as methylphenidate and atomoxetine, have improved social interaction deficits and recognition memory impairment in ASD subjects (Hara et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Abnormal Cerebellar Development Is Involved in Dystonia-Like Behaviors and Motor Dysfunction of Autistic BTBR Mice

Xiao

Zhong

et al. 2020

Front. Cell Dev. Biol.

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Motor control and learning impairments are common complications in individuals with autism spectrum disorder (ASD). Abnormal cerebellar development during critical phases may disrupt these motor functions and lead to autistic motor dysfunction. However, the underlying mechanisms behind these impairments are not clear. Here, we utilized BTBR T + Itpr tf /J (BTBR) mice, an animal model of autism, to investigate the involvement of abnormal cerebellar development in motor performance. We found BTBR mice exhibited severe dystonia-like behavior and motor coordination or motor learning impairments. The onset of these abnormal movements coincided with the increased proliferation of granule neurons and enhanced foliation, and Purkinje cells displayed morphological hypotrophy with increased dendritic spine formation but suppressed maturation. The migration of granule neurons seemed unaffected. Transcriptional analyses confirmed the differential expression of genes involved in abnormal neurogenesis and revealed TRPC as a critical regulator in proliferation and synaptic formation. Taken together, these findings indicate that abnormal cerebellar development is closely related to dystonia-like behavior and motor dysfunction of BTBR mice and that TRPC may be a novel risk gene for ASD that may participate in the pathological process of autistic movement disorders.

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“…Motor disturbances may underlie some of the behavioral core features in autism. The contribution of movements to social cognition and cascade effects on social communication in individuals with autism have been reported (5,9). Notably, therapeutic medicines for motor dysfunction, such as hyperactivity, have improved social interaction deficits and recognition memory impairment in ASD subjects (10).…”

Section: Introductionmentioning

confidence: 99%

Abnormal cerebellar development is involved in dystonia-like behaviors and motor dysfunction of autistic BTBR mice

Xiao

Zhong

et al. 2019

Preprint

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Background: Motor control and learning impairments are common complications in autistic individuals. Abnormal cerebellar development during critical phases may disrupt these motor functions and lead to the development of autistic motor dysfunction. However, the underlying mechanisms behind these impairments are not clear.Methods: Dystonic behavior was elicited using tail suspension. Motor control and learning were detected by means of the grid hang test, ladder rung walking, accelerating rotarod, and open field locomotion. Cerebellar development was morphometrically and histologically detected during critical phases. RNA sequencing was used to compare differential gene expression to provide an in-depth interpretation of molecular mechanisms.Results: BTBR mice, as a model of autism, exhibited severe dystonic behavior and motor coordination or motor learning impairments. The onset of these abnormal movements coincided with the increased proliferation of granule neurons and enhanced foliation, and Purkinje cells exhibited morphological hypotrophy with increased dendritic spine formation but suppressed maturation. The migration of granule neurons seemed unaffected. Transcriptional analyses confirmed the differential expression of genes involved in abnormal neurogenesis and revealed TRPC6 as a critical regulator in proliferation and synaptic formation. Conclusion:These findings indicate that abnormal cerebellar development is closely related to dystonia and motor dysfunction of BTBR mice and that TRPC6 may be a novel risk gene for ASD that may participate in the pathological process of autistic movement disorders.

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Cascading effects of attention disengagement and sensory seeking on social symptoms in a community sample of infants at-risk for a future diagnosis of autism spectrum disorder

Cited by 95 publications

References 53 publications

Linking risk factors and outcomes in autism spectrum disorder: is there evidence for resilience?

Linking risk factors and outcomes in autism spectrum disorder: is there evidence for resilience?

Abnormal Cerebellar Development Is Involved in Dystonia-Like Behaviors and Motor Dysfunction of Autistic BTBR Mice

Abnormal cerebellar development is involved in dystonia-like behaviors and motor dysfunction of autistic BTBR mice

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