Case 1-1999

Vartanian, Timothy; Monte, Suzanne de la

doi:10.1056/nejm199901143400208

Cited by 23 publications

(1 citation statement)

References 38 publications

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“…Although AHL and ADEM share a common aetiology, i.e. autoimmune process directed against CNS myelin, clinically, hyperacute onset, rapid progression and high mortality seen in AHL help in differentiating it from ADEM [ 7 ]. Similarly, both ADEM and AHL on imaging are characterised by perivenular demyelination and inflammation predominantly involving white matter, but asymmetric or symmetric subcortical white matter involvement of posterior fronto-parietal lobes with relative sparing of the cortex is characteristic of AHL.…”

Section: Discussionmentioning

confidence: 99%

Covid-19-associated acute haemorrhagic leukoencephalomyelitis

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Covid-19-associated acute haemorrhagic leukoencephalomyelitis

et al. 2020

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Acute hemorrhagic leukoencephalitis with severe brainstem and spinal cord involvement: MRI features with neuropathological confirmation

Pinto

Taipa

Moreira

et al. 2011

Magnetic Resonance Imaging

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Acute hemorrhagic leukoencephalitis (AHLE) is a rare and fulminant demyelinating disease considered to be the most severe form of acute disseminated encephalomyelitis (ADEM). A 70-year-old man was admitted to our emergency department (ED) after 1 week of unspecific abdominal symptoms and moderate fever in the first 3 days. Within the ED he developed a rapid onset coma and flaccid tetraparesis. Cerebrospinal fluid (CSF) analysis showed mild polymorphonuclear pleocytosis and magnetic resonance imaging (MRI) revealed supratentorial focal white matter lesions and diffuse involvement of the medulla and spinal cord. A presumptive diagnosis of ADEM was made and the patient was treated with corticosteroids followed by intravenous immunoglobulin. His neurological state did not improve and the MRI on day 8 after admission showed an increased number of lesions, mainly in the brainstem, with hemorrhagic foci. The patient died the following day and pathological features confirmed the diagnosis of AHLE. This is a unique presentation of a rare disease with detailed MRI characteristics and pathological confirmation. Although this condition is usually fatal, early recognition and aggressive therapeutic management can facilitate survival.

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Acute Disseminated Encephalomyelitis and Acute Hemorrhagic Encephalomyelitis

2005

Magnetic Resonance of Myelination and Myelin Disorders

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Case 1-1999

Cited by 23 publications

References 38 publications

Covid-19-associated acute haemorrhagic leukoencephalomyelitis

Covid-19-associated acute haemorrhagic leukoencephalomyelitis

Acute hemorrhagic leukoencephalitis with severe brainstem and spinal cord involvement: MRI features with neuropathological confirmation

Acute Disseminated Encephalomyelitis and Acute Hemorrhagic Encephalomyelitis

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