Case 16-2000

Pillemer, E; Harris, Nancy L.

doi:10.1056/nejm200005253422108

Cited by 9 publications

(2 citation statements)

References 19 publications

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“…Breast lymphoma can rarely present with extended lymphedema, stimulating inflammatory breast carcinoma. To the best of our knowledge, three cases of HL with breast inflammatory presentation have been reported so far [14, 15, 20]. Our case shows similarities with the previous reports regarding the clinical appearance.…”

Section: Discussionsupporting

confidence: 87%

“…Furthermore, keratin positivity in a breast FNA showing large malignant cells among abundant lymphoid population can confirm the diagnosis of medullary carcinoma, which may pause diagnostic difficulties. Histological study, which followed, confirmed the unexpected cytological diagnosis, reporting a classical HL of nodular sclerosis subtype, commonly observed involving the breast [4, 5, 12, 14, 15, 17, 20, 22].…”

Section: Discussionmentioning

confidence: 61%

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Hodgkin Lymphoma Mimicking Inflammatory Breast Carcinoma: A Rare Case with Diagnostic Challenge and Novel Treatment

Thodou

Befani²,

Triantafyllidis³

et al. 2019

Case Reports in Hematology

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Extranodal Hodgkin lymphoma involving the breast is infrequent. Most cases reported in the literature were diagnosed by histology after lumpectomy. We present a Hodgkin lymphoma mimicking inflammatory breast carcinoma in a 57-year-old woman. The diagnosis was performed by fine-needle aspiration (FNA) of the breast lesion and the axillary lymph nodes with rapid on-site evaluation followed by immunocytochemistry, and it was confirmed by histology. The patient after first-line chemotherapy developed relapse/refractory disease. Salvage chemotherapy regimens were applied with poor results and severe toxicity. Total remission was achieved with monotherapy of brentuximab vedotin, a novel anti-CD30-targeted antibody drug conjugate. This is a unique case of breast HL with misleading clinical presentation initially diagnosed by cytology. FNA as a minimally invasive diagnostic tool was crucial in avoiding unnecessary breast surgery and further delay of chemotherapy. It is also the first report highlighting the importance of this novel immunotherapy in the management of refractory Hodgkin lymphoma with breast involvement.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 61%

Hodgkin Lymphoma Mimicking Inflammatory Breast Carcinoma: A Rare Case with Diagnostic Challenge and Novel Treatment

Thodou

Befani²,

Triantafyllidis³

et al. 2019

Case Reports in Hematology

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Reed‐sternberg cells in breast FNA of a patient with left breast mass

Park

Rizzo

Jackson³

et al. 2010

Diagnostic Cytopathology

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Hodgkin's lymphoma is a potentially curable malignancy of the lymphatic system characterized by a variable number of scattered and large mononucleated and multinucleated tumor cells, the Hodgkin and Reed-Sternberg cells residing in an abundant heterogeneous admixture of non-neoplastic inflammatory cells. It represents approximately 30% of all lymphomas according to the World Health Organization (WHO). Patients with Hodgkin's lymphoma typically present with painless peripheral adenopathy, fever, night sweats, and weight loss. We report a rare case of Hodgkin's lymphoma presented as a breast mass in a 23-year-old woman diagnosed on fine needle aspiration (FNA). At presentation, she had no B symptoms, or palpable lymphadenopathy.

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