Case 24-2022: A 31-Year-Old Man with Perianal and Penile Ulcers, Rectal Pain, and Rash

Basgoz, Nesli; Brown, Catherine; Smole, Sandra; Madoff, Lawrence C.; Biddinger, Paul D.; Baugh, Joshua J; Shenoy, Erica S.

doi:10.1056/nejmcpc2201244

Cited by 63 publications

(87 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This pathogen causes a two-clinical stage illness, including a prodrome during its invasive period and a cutaneous phase defined as the skin eruption [ 7 ]. Although described over decades, the current ongoing outbreak outside Africa seems to present atypical clinical manifestations compared to cases reported before 2022 in endemic countries [ 8 – 10 ]. The MPXV, taxonomically, is currently part of the genus Orthopoxvirus, which belongs to the subfamily Chordopoxvirinae in the family Poxviridae.…”

Section: Introductionmentioning

confidence: 99%

“…Although only two months have elapsed since the global spreading of MPX in 2022 [ 17 ], some studies and case reports have been already published in major international scientific and medical journals from European and other countries with travel- and non-travel-related cases [ 8 , 9 , 18 , 19 ]. Many of these reports have started to answer clinical questions, including evolution and outcomes, potential risk factors, and clinical, especially dermatological findings [ 20 ]; however, a systematic review consolidates what has been learned from each study or reported case is to date missing.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical features, hospitalisation and deaths associated with monkeypox: a systematic review and meta-analysis

Benítes-Zapata

Ulloque-Badaracco

Alarcón-Braga

et al. 2022

Ann Clin Microbiol Antimicrob

111

View full text Add to dashboard Cite

Introduction A multicountry monkeypox disease (MPX) outbreak began in May 2022 in Europe, leading to the assessment as a potential Public Health Emergency of International Concern (PHEIC) on June 23, 2022. Some observational studies have partially characterised clinical features, hospitalisations, and deaths. However, no systematic reviews of this MPX outbreak have been published. Methods We performed a systematic review with meta-analysis, using five databases to assess clinical features, hospitalisations, complications and deaths of MPX confirmed or probable cases. Observational studies, case reports and case series, were included. We performed a random-effects model meta-analysis to calculate the pooled prevalence and 95% confidence interval (95% CI). In addition, we carried out a subgroup analysis according to the continents and a sensitivity analysis excluding studies classified as having a high risk of bias. Results A total of 19 articles were included, using only 12 articles in the quantitative synthesis (meta-analysis). For 1958 patients, rash (93%, 95% CI 80–100%), fever (72%, 95% CI 30–99%), pruritus (65%, 95% CI 47–81%), and lymphadenopathy (62%, 47–76%), were the most prevalent manifestations. Among the patients, 35% (95% CI 14–59%) were hospitalised. Some 4% (95% CI 1–9%) of hospitalised patients had fatal outcomes (case fatality rate, CFR). Conclusion MPX is spreading rapidly, with a third of hospitalised patients, but less than 5% with fatal outcomes. As this zoonotic virus spreads globally, countries must urgently prepare human resources, infrastructure and facilities to treat patients according to the emerging guidelines and the most reliable clinical information.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical features, hospitalisation and deaths associated with monkeypox: a systematic review and meta-analysis

Benítes-Zapata

Ulloque-Badaracco

Alarcón-Braga

et al. 2022

Ann Clin Microbiol Antimicrob

111

View full text Add to dashboard Cite

show abstract

“…The number of skin lesions may range from a few to thousands. The current outbreak of MPXV infection is characterized by several atypical features such as shorter incubation phase 11 , and milder clinical presentation often associated with localized rash and lesions in genital and perianal sites, sometimes highly painful 3, 4, 5 . Importantly, severe disease can occur in immunocompromised patients, pregnant women, and children.…”

Section: Main Textmentioning

confidence: 99%

“…Since May 2022, MPXV is causing the largest human outbreak ever recorded outside of Africa 2 . Recent studies report atypical demographics and clinical findings in cases of MPXV, mainly but not exclusively found in men who have sex with men 3, 4, 5 . The first suspected case in France was a male patient consulting at an HIV and sexual health center on May 19 th , 2022 for vesiculopustular lesions on the face and the genital organs, with no reported travel history.…”

Section: Main Textmentioning

confidence: 99%

Tecovirimat is highly efficient on the Monkeypox virus lineage responsible for the international 2022 outbreak

Frenois-Veyrat

Gallardo²,

Gorgé³

et al. 2022

Preprint

View full text Add to dashboard Cite

The ongoing monkeypox virus (MPXV) outbreak is the largest ever recorded outside of Africa. Genomic analysis revealed a divergent phylogenetic lineage within clade 3, and atypical clinical presentations have been noted. We report the sequencing and isolation of the virus from the first clinical case diagnosed in France in May 2022. We tested the in vitro effect of tecovirimat (ST-246), a FDA approved drug, against this novel strain, showing efficacy at the nanomolar range. In comparison, cidofovir showed activity at micromolar concentrations. These results and the safety profile of tecovirimat strongly support its use in clinical care of severe forms for the 2022 MPXV outbreak.

show abstract

“…An estimated 10% of new HIV infections were attributable to the chlamydial or gonococcal disease. Recently published reports have described cases of Monkeypox with genital lesions, a factor associated with an increased risk of acquisition of HIV infection [ 14 , 15 , 16 ].…”

mentioning

confidence: 99%

Monkeypox: Another Sexually Transmitted Infection?

Rodríguez-Morales

Lopardo

2022

Pathogens

View full text Add to dashboard Cite

show abstract

Case 24-2022: A 31-Year-Old Man with Perianal and Penile Ulcers, Rectal Pain, and Rash

Cited by 63 publications

References 11 publications

Clinical features, hospitalisation and deaths associated with monkeypox: a systematic review and meta-analysis

Clinical features, hospitalisation and deaths associated with monkeypox: a systematic review and meta-analysis

Tecovirimat is highly efficient on the Monkeypox virus lineage responsible for the international 2022 outbreak

Monkeypox: Another Sexually Transmitted Infection?

Contact Info

Product

Resources

About