Case 44131

Cabot, Richard C.; Castleman, Benjamin; Kibbee, Betty U.

doi:10.1056/nejm195803272581308

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2015

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Cited by 12 publications

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“…I particularly remember a case of hemochromatosis in a woman who had been taking ferrous sulfate daily for over 40 years. 46 That was the start of my medical education. I subscribed to the New England Journal of Medicine through college, graduate school, and medical school, and I still subscribe today.…”

Section: Pathological Discussionmentioning

confidence: 99%

Case 9-2015

Miller¹,

Dickerson²,

Lucente³

et al. 2015

N Engl J Med

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Section: Pathological Discussionmentioning

confidence: 99%

Case 9-2015

Miller¹,

Dickerson²,

Lucente³

et al. 2015

N Engl J Med

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Iron overload and prolonged ingestion of iron supplements: Clinical features and mutation analysis of hemochromatosis‐associated genes in four cases

et al. 2006

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We evaluated and treated four white adults (one man, three women) who had iron overload associated with daily ingestion of iron supplements for 7, 15, 35, and 61 years, respectively. We performed HFE mutation analysis to detect C282Y, H63D, and S65C in each patient; in two patients, HFE exons were sequenced. In two patients, direct sequencing was performed to detect coding region mutations of TFR2, HAMP, FPN1, HJV, and ALAS2. Patients 1-4 ingested~153, 547, 1,341, and 4,898 g of inorganic iron as supplements. Patient 1 had hemochromatosis, HFE C282Y homozygosity, and b-thalassemia minor. Patient 2 had spherocytosis and no HFE coding region mutations. Patient 3 had no anemia, a normal HFE genotype, and no coding region mutations in HAMP, FPN1, HJV, or ALAS2; she was heterozygous for the TFR2 coding region mutation V583I (nt 1,747 G?A, exon 15). Patient 4 had no anemia and no coding region mutations in HFE, TFR2, HAMP, FPN1, HJV, or ALAS2. Iron removed by phlebotomy was 32.4, 10.4, 15.2, and 4.0 g, respectively. There was a positive correlation of log 10 serum ferritin and the quantity of iron removed by phlebotomy (P = 0.0371). Estimated absorption of iron from supplements in patients 1-4 was 20.9%, 1.9%, 1.1%, and 0.08%. We conclude that the clinical phenotypes and hemochromatosis genotypes of adults who develop iron overload after ingesting iron supplements over long periods are heterogeneous. Therapeutic phlebotomy is feasible and effective, and would prevent complications of iron overload. Am. J. Hematol. 81:760-767, 2006. V V C 2006 Wiley-Liss, Inc.

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Idiopathische Hämochromatose und Lebercirrhose mit Siderose

Brunner

1966

Klin Wochenschr

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Case 44131

Cited by 12 publications

References 12 publications

Case 9-2015

Case 9-2015

Iron overload and prolonged ingestion of iron supplements: Clinical features and mutation analysis of hemochromatosis‐associated genes in four cases

Idiopathische Hämochromatose und Lebercirrhose mit Siderose

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