Case-by-Case Surveillance for Bacterial Meningitis in Benin: Data Analysis, 2016 to 2018

Godjedo, Togbemabou Primous Martial; Paraïso, Moussiliou Noël; Agbankpé, Alidehou Jerrold; Dougnon, Tamègnon Victorien; Dégbey, Cyriaque; Ahoyo, Angèle; Baba-Moussa, Lamine; Bankolè, Honoré

doi:10.4236/ojepi.2020.101001

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…Benin, a country located in West Africa, has made significant progress in the fight against vaccine-preventable diseases by significantly increasing its routine immunization coverage [6]. The northern zone of Benin is in the meningitis belt of Lapaysonnie, with a dry season from November to May during which the Harmattan blows, bringing dust and sand storms [7]. Since 1996 and almost every year, epidemics of meningococcal meningitis have been recorded, leading to deaths and various complications.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Epidemiological Surveillance System for Bacterial Meningitis in Benin from 2016 to 2018: Case-by-Case Surveillance

Godjedo¹,

Paraïso²,

Agbankpé³

et al. 2020

WJPH

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Section: Introductionmentioning

confidence: 99%

Assessment of the Epidemiological Surveillance System for Bacterial Meningitis in Benin from 2016 to 2018: Case-by-Case Surveillance

Godjedo¹,

Paraïso²,

Agbankpé³

et al. 2020

WJPH

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Epidemiological Characteristics of Meningococcal Meningitis (2016 to 2018) Four Years after the Introduction of Serogroup A Meningococcal Conjugate Vaccine in Benin

Godjedo

Agbankpé

Paraïso

et al. 2020

Advances in Public Health

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Objectives. This study aims to study the epidemiological and geographic characteristics of the meningococcal serogroups four years after the introduction of serogroup A meningococcal conjugate vaccine. Methods. This is a prospective, descriptive, analytical study, and it took place from 2016 to 2018. Cerebrospinal fluid (CSF) samples were taken after the identification of meningitis cases. The samples, thus, taken were sent to the laboratory for culture and identification of Neisseria meningitidis in accordance with WHO standards. Results. Eight hundred and ninety-nine bacterial strains were identified, of which 219 were strains of Neisseria meningitidis. The majority of N. meningitidis-positive samples were from male patients (59.8%) with a median age of 4 (IQR: 1–13). Four of N. meningitidis serogroups were identified, namely, serogroups C (6.8%), W (19.6%), X (1.8%), and A (0.5%). Geographically, 92.7% of the identified N. meningitidis serogroups came from patients who lived in the northern region of the country. The departments most concerned were Alibori (N. meningitidis C (66.7%) and N. meningitidis W (20.9%)); Atacora (N. meningitidis W (41.9%), N. meningitidis X (75.0%), and N. meningitidis C (13.3%)); and Borgou (N. meningitidis W (23.3%)). Conclusion. The results of this study showed that there is an emergence of cases of meningococcal of serogroup C four years after the introduction of MenAfricVac in Benin. These results demonstrated the effectiveness of case-by-case surveillance in detecting small changes in the distribution of serogroups that could have important implications for public health strategies in the coming seasons.

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Spectrum of central nervous system infections in a tertiary health care centre in Cameroon

Massi

Mintyene

Magnerou

et al. 2022

Egypt J Neurol Psychiatry Neurosurg

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Background Central nervous system (CNS) infections are serious and debilitating diseases with significant mortality, and high prevalence in the context of human immunodeficiency virus (HIV) pandemic in Africa. However, their diagnosis remains challenging due to outdated technical platform. We aimed to determine the frequency of CNS infection and to describe the epidemiological, clinical and outcome of this at the Douala General Hospital (DGH), Cameroon. To carry out this study, we collected the medical records of patients hospitalized for CNS infections in the internal medicine department of DGH from January 2015 to December 2019. Results Among 8430 files reviewed, 336 cases of CNS infection were identified giving a frequency of CNS infection of 3.99% among which 204 files were included in the study (54.4% were male). HIV infection was found in 147 patients (72.1%) with 38.1% (n = 56) of them on regular follow-up. The most common clinical signs were fever (84.8%), headache (68.6%), meningeal syndrome (38.7%), and seizures (36.3%). Cerebral toxoplasmosis (24.5%), cryptococcal meningitis (21.1%), and acute bacterial meningitis (8.3%) were leading aetiologies. Of the 143 CSF samples, 70.6% (n = 101) were sterile. The in-hospital mortality rate was 23.5% with CNS infection of unknown cause (22.1%) be independently associated to this [OR = 2.24; 95% CI 1.04–4.80, p = 0.039]. Conclusion Clinical presentations of CNS infections are same with classical data. HIV-related opportunistic infections are the main aetiologies. About one over four patients with CNS died. Two thirds of CSF are sterile using basic laboratory assessment giving a need to identify simple tests to increase sensibility and specificity of diagnostic tools in our setting.

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Case-by-Case Surveillance for Bacterial Meningitis in Benin: Data Analysis, 2016 to 2018

Cited by 3 publications

References 19 publications

Assessment of the Epidemiological Surveillance System for Bacterial Meningitis in Benin from 2016 to 2018: Case-by-Case Surveillance

Assessment of the Epidemiological Surveillance System for Bacterial Meningitis in Benin from 2016 to 2018: Case-by-Case Surveillance

Epidemiological Characteristics of Meningococcal Meningitis (2016 to 2018) Four Years after the Introduction of Serogroup A Meningococcal Conjugate Vaccine in Benin

Spectrum of central nervous system infections in a tertiary health care centre in Cameroon

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