Case-control study: Determination of potential risk factors for the colonization of healthy volunteers with Streptococcus gallolyticus subsp. gallolyticus

Dumke, Jessika; Vollmer, Tanja; Akkermann, O.; Knabbe, Cornelius; Dreier, Jens

doi:10.1371/journal.pone.0176515

Cited by 26 publications

(19 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whether SGG plays an etiological role precipitating the occurrence of polyps and tumors or acquires a strong colonization property in response to a favorable ecological environment created by the tumor itself or preexisting conditions remains unknown. It is worth mentioning that, even though asymptomatic carriage of SGG is estimated to be between 5% and 15% in the literature, mostly using enrichment on selective media and culture techniques, a recent study indicated a much higher carriage rate (∼60%) by using quantitative realtime PCR (28).…”

Section: Discussionmentioning

confidence: 99%

Colorectal cancer specific conditions promote Streptococcus gallolyticus gut colonization

Aymeric

Donnadieu

Mulet

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

118

132

View full text Add to dashboard Cite

Colonization by subsp. (SGG) is strongly associated with the occurrence of colorectal cancer (CRC). However, the factors leading to its successful colonization are unknown, and whether SGG influences the oncogenic process or benefits from the tumor-prone environment to prevail remains an open question. Here, we elucidate crucial steps that explain how CRC favors SGG colonization. By using mice genetically prone to CRC, we show that SGG colonization is 1,000-fold higher in tumor-bearing mice than in normal mice. This selective advantage occurs at the expense of resident intestinal enterococci. An SGG-specific locus encoding a bacteriocin ("gallocin") is shown to kill enterococci in vitro. Importantly, bile acids strongly enhance this bacteriocin activity in vivo, leading to greater SGG colonization. Constitutive activation of the Wnt pathway, one of the earliest signaling alterations in CRC, and the decreased expression of the bile acid apical transporter gene , as an effect of the founding mutation, may thereby sustain intestinal colonization by SGG. We conclude that CRC-specific conditions promote SGG colonization of the gut by replacing commensal enterococci in their niche.

show abstract

Section: Discussionmentioning

confidence: 99%

Colorectal cancer specific conditions promote Streptococcus gallolyticus gut colonization

Aymeric

Donnadieu

Mulet

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

118

132

View full text Add to dashboard Cite

show abstract

“…The counts ≥ 10 8 cfu were found in the Livanjski cheeses after salting (S2, S4). Streptococcus gallolyticus is known as part of the microbiota in artisan raw milk cheeses (Pacini et al ; Gaglio et al ) but is also noted as a facultative human pathogen (Dumke et al ). The occurrence of Str.…”

Section: Discussionmentioning

confidence: 99%

Microbial diversity of Livanjski cheese with the emphasis on lactic acid bacteria based on culture‐dependent and sequencing method

Dráb¹,

Kavková²,

Markéta³

et al. 2019

Int J of Dairy Tech

View full text Add to dashboard Cite

The microbial diversity of artisanal Livanjski cheese from traditional farms and dairies was analysed. The polyphasic approach included the isolation of microorganisms by using culture-dependent methods and the identification of viable isolates by sequencing methods. In total, 159 isolates were identified, including five strains of yeast and 15 strains of fungi. Twenty-two species of homofermentative and heterofermentative lactic acid bacteria were classified. The Shannon-Wiener index of diversity ranged from 0.462 to 2.51 within the cheese samples from the farms and dairies. The hygiene conditions during cheese production and the age of the cheese significantly influenced the counts and diversity of microorganisms.

show abstract

“…The fecal carriage rate of SBSEC member in humans is varying from five to over 60% (Table 1 ) (Klein et al, 1977 ; Noble, 1978 ; Potter et al, 1998 ; Abdulamir et al, 2010 ; Al-Jashamy et al, 2010 ; Chirouze et al, 2013 ; Lopes et al, 2014 ; Boltin et al, 2015 ; Dumke et al, 2017 ; Kaindi et al, 2017 ). This variation might depend on detection techniques and regional differences.…”

Section: Prevalence and Colonization Of Sbsec In Animals And Humansmentioning

confidence: 99%

“…Furthermore, most studies were conducted using a hospital-derived population with possible differences in age, sex and underlying diseases that limits extrapolation to the general population. (Huang et al, 2008 ; Chirouze et al, 2013 ; Lopes et al, 2014 ; Dumke et al, 2017 ; Harris et al, 2017 ). Oral niche colonization in humans seems to be infrequent, but isolation of SII, SGP , and SE was confirmed from dental plaques and root caries lesions (Sissons et al, 1988 ; Shen et al, 2005 ; Arul and Palanivelu, 2014 ).…”

Section: Prevalence and Colonization Of Sbsec In Animals And Humansmentioning

confidence: 99%

The Road to Infection: Host-Microbe Interactions Defining the Pathogenicity of Streptococcus bovis/Streptococcus equinus Complex Members

Jans¹,

Boleij²

2018

Front. Microbiol.

View full text Add to dashboard Cite

The Streptococcus bovis/Streptococcus equinus complex (SBSEC) comprises several species inhabiting the animal and human gastrointestinal tract (GIT). They match the pathobiont description, are potential zoonotic agents and technological organisms in fermented foods. SBSEC members are associated with multiple diseases in humans and animals including ruminal acidosis, infective endocarditis (IE) and colorectal cancer (CRC). Therefore, this review aims to re-evaluate adhesion and colonization abilities of SBSEC members of animal, human and food origin paired with genomic and functional host-microbe interaction data on their road from colonization to infection. SBSEC seem to be a marginal population during GIT symbiosis that can proliferate as opportunistic pathogens. Risk factors for human colonization are considered living in rural areas and animal-feces contact. Niche adaptation plays a pivotal role where Streptococcus gallolyticus subsp. gallolyticus (SGG) retained the ability to proliferate in various environments. Other SBSEC members have undergone genome reduction and niche-specific gene gain to yield important commensal, pathobiont and technological species. Selective colonization of CRC tissue is suggested for SGG, possibly related to increased adhesion to cancerous cell types featuring enhanced collagen IV accessibility. SGG can colonize, proliferate and may shape the tumor microenvironment to their benefit by tumor promotion upon initial neoplasia development. Bacteria cell surface structures including lipotheichoic acids, capsular polysaccharides and pilus loci (pil1, pil2, and pil3) govern adhesion. Only human blood-derived SGG contain complete pilus loci and other disease-associated surface proteins. Rumen or feces-derived SGG and other SBSEC members lack or harbor mutated pili. Pili also contribute to binding to fibrinogen upon invasion and translocation of cells from the GIT into the blood system, subsequent immune evasion, human contact system activation and collagen-I-binding on damaged heart valves. Only SGG carrying complete pilus loci seem to have highest IE potential in humans with significant links between SGG bacteremia/IE and underlying diseases including CRC. Other SBSEC host-microbe combinations might rely on currently unknown mechanisms. Comparative genome data of blood, commensal and food isolates are limited but required to elucidate the role of pili and other virulence factors, understand pathogenicity mechanisms, host specificity and estimate health risks for animals, humans and food alike.

show abstract

Case-control study: Determination of potential risk factors for the colonization of healthy volunteers with Streptococcus gallolyticus subsp. gallolyticus

Cited by 26 publications

References 50 publications

Colorectal cancer specific conditions promote Streptococcus gallolyticus gut colonization

Colorectal cancer specific conditions promote Streptococcus gallolyticus gut colonization

Microbial diversity of Livanjski cheese with the emphasis on lactic acid bacteria based on culture‐dependent and sequencing method

The Road to Infection: Host-Microbe Interactions Defining the Pathogenicity of Streptococcus bovis/Streptococcus equinus Complex Members

Contact Info

Product

Resources

About