Case–Control Study Examining the Composition of the Gut Microbiome in Individuals With and Without Immune-Mediated Dry Eye

Goodman, Courtney F; Doan, Thuy; Mehra, Divy; Betz, Jason; Locatelli, Elyana; Mangwani-Mordani, Simran; Kalahasty, Karthik; Hernandez, Mireya; Hwang, Jodi

doi:10.1097/ico.0000000000003195

Cited by 5 publications

(1 citation statement)

References 44 publications

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“…Overall, despite these promising preclinical results, clinical evidence remains limited to Sjögren's syndrome. Thus, further studies are needed to better clarify the direct effect of GM alterations on dry eye symptoms [150].…”

Section: Dry Eye Diseasementioning

confidence: 99%

Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases

Campagnoli,

Varesi,

Barbieri

et al. 2023

IJMS

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The human microbiota refers to a large variety of microorganisms (bacteria, viruses, and fungi) that live in different human body sites, including the gut, oral cavity, skin, and eyes. In particular, the presence of an ocular surface microbiota with a crucial role in maintaining ocular surface homeostasis by preventing colonization from pathogen species has been recently demonstrated. Moreover, recent studies underline a potential association between gut microbiota (GM) and ocular health. In this respect, some evidence supports the existence of a gut–eye axis involved in the pathogenesis of several ocular diseases, including age-related macular degeneration, uveitis, diabetic retinopathy, dry eye, and glaucoma. Therefore, understanding the link between the GM and these ocular disorders might be useful for the development of new therapeutic approaches, such as probiotics, prebiotics, symbiotics, or faecal microbiota transplantation through which the GM could be modulated, thus allowing better management of these diseases.

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Section: Dry Eye Diseasementioning

confidence: 99%