Case–control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma

Abstract

This study examined the association between coffee consumption and the risk of endometrial endometrioid adenocarcinoma (EEA) in Japan by a case-control design. The cases consisted of 107 women less than 80 years of age from two medical centers who had been histopathologically diagnosed to have EEA. The controls, selected from the participants of a cancer-screening program, were 214 women, with two controls selected for each case (matched for age and for area of residence). A self-administered questionnaire containing questions to determine dietary and beverage consumption, as well as reproductive history, was distributed to the cases and controls. Conditional logistic regression analysis was used to estimate the odds ratio (OR) of EEA for three levels of coffee consumption with adjustment for potential confounding factors. The multivariate-adjusted OR of EEA for individuals in the highest tertile of coffee consumption (2 to 3 cups or more/day) was 0.4 [95% confidence interval (CI), 0.2-0.9], and that of cases in the intermediate tertile (5 to 6 times/week-1 cup/day) was 0.6 (95% CI, 0.3-1.2), relative to the individuals in the lowest tertile of coffee consumption (3 to 4 times or less/week) (P for trend=0.014). The above association was observed in postmenopausal women (P for trend=0.016), but not in premenopausal women (P for trend=0.90). This study thus revealed an inverse dose-response relationship between coffee consumption and the risk of EEA, and its strong association in postmenopausal women but not in premenopausal women.

Coffee consumption and risk of endometrial cancer: A prospective study in Japan

“…Of 8 studies, 4 case-control studies showed an inverse association 15-18 whereas 3 case-control 12-14 and 1 prospective cohort studies found no association. 19 Our results were in agreement with previous case-control studies which reported a decreased risk of endometrial cancer with coffee consumption in Japan, 17,18 Greece 16 and Sweden. 15 All these studies were conducted in countries where the prevalence of HRT use is relatively low, 25 except for that in Sweden.…”

“…To date, only 1 case-control study has reported an association between coffee consumption and risk of endometrial cancer in postmenopausal women with practically no HRT. 18 The study found that coffee consumption was inversely associated with endometrial cancer in postmenopausal but not in premenopausal women in Japan, 18 where the prevalence of HRT use is low. 24 In our study, although we could not obtain information on menopausal status at diagnosis of endometrial cancer, 79% of cases in premenopausal women at baseline were aged 50 years or older at diagnosis.…”

“…24,25 Indeed, the 2 case-control studies conducted in Japan found a significant decrease in risk of endometrial cancer in association with coffee consumption. 17,18 Here, we prospectively assessed the association between coffee consumption and endometrial cancer among Japanese women based on a large-scale population-based study.…”

“…[12][13][14][15][16][17][18] The only prospective study to assess the relation of coffee consumption with endometrial cancer, conducted in Norway, found no association. 19 Several studies on the association between diet and endometrial cancer found a more pronounced association among never users of hormone replacement therapy (HRT) [20][21][22] or unopposed estrogen 23 than among users.…”

Case–control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma

“…The details of the design and setting of this study have already been described [15]. Briefly, we defined cases as women who met the following criteria: (1) those who were diagnosed as having endometrial cancer and underwent total hysterectomy at either Tohoku University Hospital between November 2002 and the end of March 2007 or Miyagi Cancer Center between June 2005 and the end of June 2006; (2) those under 80 years of age and residents of Miyagi Prefecture, Japan; (3) those whose cancer was histopathologically diagnosed as EEA; and (4) those with no history of cancer at any other organ or site.…”