Case–control study of <i>Staphylococcus lugdunensis</i> infection isolates from small companion animals

Rook, Kathryn A.; Brown, Dorothy Cimino; Rankin, Shelley C.; Morris, Daniel O.

doi:10.1111/j.1365-3164.2012.01087.x

Cited by 15 publications

(15 citation statements)

References 30 publications

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“…However, recent evidence suggests that some CNS (most notably S. schleiferi ssp. schleiferi, S. epidermidis and S. lugdunensis) may be associated with clinical infection in multiple host species, including humans, dogs and cats (Rook et al 2012;Misic et al 2015;Seng et al 2017;Yamada et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Characterization, distribution, antimicrobial resistance and resistance risk factors in staphylococci isolated from cats from 2001 to 2014

Lane

Roy²,

Kearney

et al. 2018

Veterinary Medicine & Sci

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Relatively few studies have been published describing the patterns of staphylococcal isolation and antimicrobial resistance over time in cats. The objective of this retrospective study was to determine the frequency, location, characteristics and antimicrobial resistance profiles of staphylococci isolated by the Louisiana Animal Disease Diagnostic Laboratory between the years 2001 and 2014. All feline staphylococcal isolates were classified phenotypically. Isolates corresponding to known or possibly pathogenic species (Staphylococcus intermedius group (SIG) and Staphylococcus aureus (SA)) as well as Staphylococcus epidermidis (SE) and non‐speciated coagulase‐negative staphylococci (CNS) were further evaluated to determine antimicrobial resistance patterns. A total of 519 staphylococci were isolated. The largest percentage of isolates was CNS, representing 39.3% of the total, while SIG, SE, SA and non‐speciated coagulase positive staphylococci (CPS) represented 18.1%, 10.2%, 8.3% and 7.3%, respectively. Methicillin resistance (MR) was identified in 57.1% of SA and 20.5% of SIG. Resistance to 3 or more antimicrobial classes (multidrug resistance; MDR) was demonstrated in 54.5% of SA and 23.9% of SIG. The prevalence of MDR increased over time in both SIG and SA, while the prevalence of MR increased over time in SIG. An increase in mean antimicrobial resistance score over time was seen in SIG. This study demonstrates a high and increasing prevalence of MDR in SIG and SA, as well as increasing prevalence of MR in SIG isolated from cats.

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Section: Introductionmentioning

confidence: 99%

Characterization, distribution, antimicrobial resistance and resistance risk factors in staphylococci isolated from cats from 2001 to 2014

Lane

Roy²,

Kearney

et al. 2018

Veterinary Medicine & Sci

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“…S. lugdunensis typically has been associated with human disease, primarily skin infections and endocarditis, but recently also has been described as an animal pathogen (Frank et al, 2008; Rook et al, 2012). S. schleiferi , which may be coagulase negative (CNS: subsp.…”

mentioning

confidence: 99%

“…In animals, a number of case reports and a recent case-control study demonstrate a variety of infections in pets, predominantly dogs but also cats, birds, and small mammalian “pocket” pets (Briscoe et al, 2009; Beck et al, 2012; Nakamura et al, 2012; Rook et al, 2012). One of these case reports described a methicillin-resistant S. lugdunensis ( mecA gene not tested) isolated from a dog that died of vegetative endocarditis (Nakamura et al, 2012).…”

mentioning

confidence: 99%

“…One of these case reports described a methicillin-resistant S. lugdunensis ( mecA gene not tested) isolated from a dog that died of vegetative endocarditis (Nakamura et al, 2012). In the case-control study, S. lugdunensis cases were compared to S. pseudintermedius controls, and cases demonstrated associations with respiratory or skin infections, in-patient status, and prior use of steroids (Rook et al, 2012). S. lugdunensis also has been isolated from carriage sites in healthy animals (Kasprowicz et al, 2011; Beck et al, 2012).…”

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confidence: 99%

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Two coagulase-negative staphylococci emerging as potential zoonotic pathogens: wolves in sheep's clothing?

et al. 2013

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“…Two staphylococcal species, S. lugdunensis and S. schleferi, have been described as emerging zoonotic pathogens [71]. Staphylococcus lugdunensis, which is known to cause skin infections and invasive infections, such as endocarditis, osteomyelitis and sepsis in humans, has more recently been described as an animal pathogen implicated in respiratory and skin infections [71,72]. Staphylococcus schleiferi, which has typically been associated with skin infections in pet animals, has also been found associated with endocarditis and metastatic infection as well as endophthalmitis in humans [73,74].…”

Section: Staphylococcal Infections In Humansmentioning

confidence: 99%

Antimicrobial Resistance in Staphylococci at the Human– Animal Interface

Schmidt¹,

Kock²,

Ehlers³

2015

Antimicrobial Resistance - An Open Challenge

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The widespread and often indiscriminate use of antimicrobials in animals is considered an important driving force behind the emergence and spread of antimicrobial-resistant bacteria. The emergence of livestock-associated methicillin-resistant Staphylococcus aureus and the description of a novel methicillin-resistant gene, mecC, have renewed concerns regarding the role of animals as reservoirs and a source for the evolution of novel, virulent zoonotic pathogens. The transfer of antimicrobial-resistant bacteria residing in, or on, animals to close human contacts or the introduction of the bacteria into the food supply chain is a cause for concern. The purpose of this mini-review is to provide a background to the genus Staphylococcus and the emergence of antimicrobial resistance as well as a discussion on the most significant antimicrobial resistance mechanisms. The use of antimicrobials in animal husbandry is discussed and the interface between humans and different animal populations is closely examined. Finally, the need for antimicrobial monitoring programmes is discussed and is supplemented with information pertaining to antimicrobial susceptibility testing and molecular typing of staphylococcal isolates.

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Case–control study of Staphylococcus lugdunensis infection isolates from small companion animals

Abstract: These results suggest that S. lugdunensis may cause invasive infections in companion animals, which should be treated with antimicrobials based upon susceptibility tests when available.

Cited by 15 publications

References 30 publications

Characterization, distribution, antimicrobial resistance and resistance risk factors in staphylococci isolated from cats from 2001 to 2014

Characterization, distribution, antimicrobial resistance and resistance risk factors in staphylococci isolated from cats from 2001 to 2014

Two coagulase-negative staphylococci emerging as potential zoonotic pathogens: wolves in sheep's clothing?

Antimicrobial Resistance in Staphylococci at the Human– Animal Interface

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