Case‐control study of mesothelioma in South Africa

Rees, David; Myers, Jonny; Goodman, K.; Fourie, Elize; Blignaut, Charlmé; Chapman, Ronald; Bachmann, Max

doi:10.1002/(sici)1097-0274(199903)35:3<213::aid-ajim1>3.3.co;2-i

Cited by 21 publications

(35 citation statements)

References 11 publications

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“…Rees et al [30] used the same design as in our study A (hospital-based case-control study), but they found a higher AR p close to those estimated in population-based case-control studies. This may be due to the geographical recruitment.…”

Section: Resultssupporting

confidence: 59%

“…The proportion of exposed controls was close to that in study A and study B (68% and 57%, respectively) but the proportion of exposed cases was higher than in either study A or B (80% and 87%, respectively). This may account for the value of the estimated AR p found in the study by Rees et al [30] despite its design. …”

Section: Resultsmentioning

confidence: 82%

“…To date, several studies have analyzed the exposure-response relation between occupational asbestos exposure and mesothelioma [27][28][29][30][31][32], yet few have estimated the AR p . All these studies assessed exposure by expertise, except the work by Spirtas et al [32] (JEM), and all showed an exposure-response relation, but the magnitude of the relation differed.…”

Section: Resultsmentioning

confidence: 99%

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Attributable risk in men in two French case-control studies on mesothelioma and asbestos

Lacourt¹,

Rolland²,

Gramond³

et al. 2010

Eur J Epidemiol

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Pleural mesothelioma is a primary tumor of the pleura that is mainly due to asbestos exposure. To study the relationship between mesothelioma and occupational asbestos exposure in France, two case-control studies (A and B) were conducted. A substantial difference in the attributable risk in the population (AR p ) was observed among men: 44.5% (95% CI: [32.6 -56.4]) in study .6]) in study B. As different exposure assessment expert methods were used, the main objective of this work was to re-estimate the ARp among men in two case-control studies according to a common standardized exposure assessment by using a Job Exposure Matrix (JEM) and to assess the role of subjects" selection. The initial observed AR p difference was maintained:36.3% (95% CI: [24.3 -50.3]) in study A and 69.7% (95% CI: 51.7 -83.2]) in study B. Further investigations highlighted the potential selection bias introduced in both studies, especially among controls. The AR p could be underestimated in study A and overestimated in study B. After weighting subjects according to distribution of socio-economic status in the general population for controls and according to distribution of socio-economic status of cases registered by the French National Mesothelioma Surveillance Program, re-estimated AR p values were 52.4% in study A and 70.2% in study B. These results provide additional information to describe the relationship between pleural mesothelioma and occupational asbestos exposure, but also confirm the importance of subjects" recruitment in case control studies, particularly control selection. KEY WORDSAsbestos, attributable risk, case-control study, men, mesothelioma, occupational exposure.

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Section: Resultssupporting

confidence: 59%

Section: Resultsmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 99%

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Attributable risk in men in two French case-control studies on mesothelioma and asbestos

Lacourt¹,

Rolland²,

Gramond³

et al. 2010

Eur J Epidemiol

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“…25--27 Some studies have reported that the risk of mesothelioma was significantly affected by the distance of homes to an industrial source of asbestos. 28,29 However, asbestos fibers derived from naturally occurring asbestos may influence larger areas compared with industrial sources. Consequently, the spatial distributions of the mortality rates of mesothelioma and several other cancers caused by naturally occurring asbestos may be significantly different from those caused by industrial sources.…”

Section: Introductionmentioning

confidence: 99%

Impacts of land use on spatial distribution of mortality rates of cancers caused by naturally occurring asbestos

Wei

Jia

et al. 2012

J Expo Sci Environ Epidemiol

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This study investigated the spatial distributions of mortality rates of six cancers: mesothelioma, lung cancer, intestinal cancer, nasopharyngeal and laryngeal cancer, liver cancer, and stomach cancer in Dayao using Geographic Information Systems. Relationships between the mortality rates of the six cancers and land use patterns were investigated by Pearson Correlation Coefficients. The results indicated that the mortality rates of nasopharyngeal and laryngeal cancer, lung cancer, intestinal cancer, and mesothelioma were significantly associated with outcropped asbestos. Both the proportions of farmland and urban area were positively related to the mortality rates of nasopharyngeal and laryngeal cancer, lung cancer, intestinal cancer, and mesothelioma, and significant negative correlations were found between the proportion of forestland and nasopharyngeal and laryngeal cancer and intestinal cancer. It can be concluded that naturally occurring asbestos may significantly elevate the mortality rates of nasopharyngeal and laryngeal cancer, intestinal cancer, lung cancer, and mesothelioma. Moreover, higher proportions of farmland, urban area, and lower proportions of forested land may elevate the mortality rate of the four cancers.

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“…Subsequent studies have shown that almost all cases of mesothelioma in South Africa are associated with exposure to crocidolite asbestos (Webster, 1973;Cochrane and Webster, 1978;Rees et al, 1999a;Nolan et al, 2006). Webster considered the association with mesothelioma to be a peculiar property of Cape crocidolite (Webster, 1973).…”

Section: Crocidolitementioning

confidence: 99%

Mineralogy and Malignant Mesothelioma: The South African Experience

Phillips¹,

Rees²,

Murray³

et al. 2012

Malignant Mesothelioma

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Case‐control study of mesothelioma in South Africa

Abstract: Background South Africa has, uniquely, mined, transported, and used crocidolite, amosite, and chrysotile. A multicenter case-control Med. 35:213-222, 1999. 1999

Cited by 21 publications

References 11 publications

Attributable risk in men in two French case-control studies on mesothelioma and asbestos

Attributable risk in men in two French case-control studies on mesothelioma and asbestos

Impacts of land use on spatial distribution of mortality rates of cancers caused by naturally occurring asbestos

Mineralogy and Malignant Mesothelioma: The South African Experience

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