Case-control study of migraine and risk of ischaemic stroke in young women

Tzourio, Christophe; Tehindrazanarivelo, Alain Djacoba; Iglesias, S.; Alpérovitch, Annick; Chédru, F; d'Anglejan-Chatillon, Jacques; Bousser, Marie‐Germaine

doi:10.1136/bmj.310.6983.830

Cited by 430 publications

(424 citation statements)

References 14 publications

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“…In the rare cases when stroke was present, it seemed to occur more often in patients with aura, as has been reported before [14]. The only significant finding in this regard was that men who fulfilled the criteria of both migraine with and without aura had a 15.19 times higher risk for stroke than men without migraine.…”

Section: Discussionsupporting

confidence: 65%

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Comorbidity in Finnish migraine families

Artto

Wessman

Nissilä³

et al. 2006

J Headache Pain

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The objective of the study was to investigate comorbidity of migraine in Finnish migraine families. One thousand consecutive participants in the Finnish Migraine Gene Project reported their medical illnesses in addition to migraine and headache. Migraine patients (n=678) reported significantly more hypotension (OR 1.43, CI 95% 1.02-2.01), allergy (OR 1.83, CI 95% 1.34-2.51) and psychiatric disorders (OR 4.09, CI 95% 2.11-7.92) compared to their family members without migraine (n=322). Subgroup analyses demonstrated that especially women and the group fulfilling the criteria for both migraine with and without aura were likely to have additional disorders besides their migraine. Interestingly, male migraineurs with aura reported a significant association with stroke and epilepsy. Familial migraine is comorbid with hypotension, allergy and psychiatric disorders. The association between migraine with aura and stroke and epilepsy among men of the studied families warrants further study. Clinical, pathophysiological and genetic implications of these results are discussed.

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Section: Discussionsupporting

confidence: 65%

“…The well known association of migraine and stroke [14] was not striking. In the rare cases when stroke was present, it seemed to occur more often in patients with aura, as has been reported before [14].…”

Section: Discussionmentioning

confidence: 89%

Comorbidity in Finnish migraine families

Artto

Wessman

Nissilä³

et al. 2006

J Headache Pain

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“…Several lines of evidence suggest MA is more strongly associated with stroke than MO [3,4,12]. For our study, analysis of associations between family history of vascular risk factors and MA compared to MO found only modest positive associations, with confidence intervals that included no associations at all.…”

Section: Discussioncontrasting

confidence: 42%

“…Data from several studies suggest that migraine may be a risk factor for the development of stroke [3,4,[9][10][11][12] and MA may be an important risk factor for stroke in women [12,13]. The mechanisms that underlie these observations are unclear but a reasonable hypothesis could include the presence of shared risk factors as a possible cause.…”

Section: Discussionmentioning

confidence: 99%

Clinic–based study of family history of vascular risk factors and migraine

et al. 2005

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The objective was to evaluate the presence of a positive family history (FH) of vascular risk factors between patients with migraine with aura (MA) and migraine without aura (MO), and in chronic migraine (CM) compared to other headache types. As migraine patients are typically too young to have developed vascular events, studying older relatives of migraine patients may be a practical means of evaluating associations between vascular risk factors and migraine. A cross-sectional study of a clinicbased sample of adults with migraine headache was carried out at the University of Utah. Predictor variables comprised first or second degree relatives with stroke, hypertension, diabetes or hypercholesterolaemia. Outcome measures comprised diagnosis of MA, MO or CM according to the revised International Headache Society criteria. There was no significant difference in FH of vascular risk factors in MA compared to MO (adjusted OR 1.04, 95% CI 0.61-1.78). CM was associated with a decreased risk of FH of stroke (OR=0.11, p=0.036). There was no significant difference in FH of vascular risk factors in MA patients compared to MO. CM patients were more likely to have a negative FH of stroke compared to other headache types, suggesting that CM is likely a neuronal disease rather than a vascular one.

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“…Furthermore, another study indicated that consumption of OCPs increased the risk of stroke in migraine sufferers, irrespective of other risk factors (12). One other study revealed that consumption of OCPs in white women was accompanied by an increase in the risk of cardiovascular diseases, insulin resistance, glucose intolerance, and high triglyceride levels (13).…”

Section: Investigation Of the Relationship Between Myocardial Infarctmentioning

confidence: 99%

Investigation of the Relationship between Myocardial Infarction, Angina Pectoris, and Venous Thrombosis and Some Risk Factors in the Women Suffering from Cardiovascular Diseases with a History of Contraceptive Pills Consumption

Akbarzade

Sharifi

Zare

2016

Int Cardiovasc Res J

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A B S T R A C TBackground: Cardiovascular diseases have various etiologies. Previous studies have come to contradictory results regarding the effects of Oral Contraceptive Pills (OCPs) on the risk of myocardial infarction, angina pectoris, and venous thrombosis. Thus, further investigation is required in this area. Objectives: This study aimed to determine the relationship between cardiovascular diseases and some risk factors in the women with a history of contraceptive pills consumption. Patients and Methods:The present case-control study was conducted on 317 women with cardiovascular diseases (myocardial infarction, angina pectoris, and deep venous thrombosis) selected through simple purposive sampling from CCU, ICU, post-ICU, and neurology departments of Nemazee, Faghihi, and Al-Zahra heart hospitals. Also, 371 controls were selected among 20 -60 year-old women without cardiac diseases. The data were collected through questionnaires, interviewing the patients and their firstdegree relatives, and the patients' medical records. The main variables studied in both groups included the history of OCPs consumption, weight gain, blood sugar level, and hypertension. Then, the data were analyzed using chi-square test, correlation coefficient, and odds ratio. Besides, P < 0.05 was considered to be statistically significant. Results: The mean age of the study population was 49.2 ± 13.4 years. Besides, 10.6%, 4%, and 2.7% of the women had used OCPs for 6 -10, 11 -15, and more than 16 years, respectively. There were no significant differences between the two groups in terms of history of using OCPs (47.3% vs. 51.5%, P = 0.8). In addition, no significant relationship was observed between consumption of OCPs and incidence of myocardial infarction (P = 0.202), angina pectoris (P = 0.260), and thrombosis (P = 0.389). However, a significant difference was found between the two groups regarding the frequency of hyperlipidemia, hyperglycemia, and hypertension (P < 0.001). Conclusions:The results showed no significant association between the use of OCPs and cardiovascular diseases. Nevertheless, other risk factors of cardiovascular diseases were higher among the patients with a history of contraceptive pills consumption.

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Case-control study of migraine and risk of ischaemic stroke in young women

Cited by 430 publications

References 14 publications

Comorbidity in Finnish migraine families

Comorbidity in Finnish migraine families

Clinic–based study of family history of vascular risk factors and migraine

Investigation of the Relationship between Myocardial Infarction, Angina Pectoris, and Venous Thrombosis and Some Risk Factors in the Women Suffering from Cardiovascular Diseases with a History of Contraceptive Pills Consumption

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