Case-control study of risk factors of Creutzfeldt-Jakob disease in Europe during 1993-95

Vanduijn, C; Delasnerie-Lauprêtre, N; Masullo, Carlo; Zerr, Inga; Silva, R de; Wientjens, D. P. W. M.; Jp, Brandel; Weber, Thomas K.; Bonavita, V.; Zeidler, Martin; Alpérovitch, Annick; Poser, S.; Granieri, Enrico; Hofman, Albert; Rg, Will

doi:10.1016/s0140-6736(97)09468-3

Cited by 172 publications

(116 citation statements)

References 25 publications

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“…This strain ''affiliation'' was confirmed biochemically. There is no epidemiological evidence for a link between sheep scrapie and the occurrence of CJD in humans (25). However, such a link, if it is not a general rule, would be extremely difficult to establish because of the very low incidence of CJD as well as the existence of different isolates in humans and multiple strains in scrapie.…”

Section: Discussionmentioning

confidence: 99%

Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt– Jakob disease: Implications for human health

Lasmézas

Fournier²,

Nouvel³

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

158

117

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There is substantial scientific evidence to support the notion that bovine spongiform encephalopathy (BSE) has contaminated human beings, causing variant Creutzfeldt-Jakob disease (vCJD). This disease has raised concerns about the possibility of an iatrogenic secondary transmission to humans, because the biological properties of the primate-adapted BSE agent are unknown. We show that (i) BSE can be transmitted from primate to primate by intravenous route in 25 months, and (ii) an iatrogenic transmission of vCJD to humans could be readily recognized pathologically, whether it occurs by the central or peripheral route. Strain typing in mice demonstrates that the BSE agent adapts to macaques in the same way as it does to humans and confirms that the BSE agent is responsible for vCJD not only in the United Kingdom but also in France. The agent responsible for French iatrogenic growth hormone-linked CJD taken as a control is very different from vCJD but is similar to that found in one case of sporadic CJD and one sheep scrapie isolate. These data will be key in identifying the origin of human cases of prion disease, including accidental vCJD transmission, and could provide bases for vCJD risk assessment.

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Section: Discussionmentioning

confidence: 99%

Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt– Jakob disease: Implications for human health

Lasmézas

Fournier²,

Nouvel³

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

158

117

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show abstract

“…One study has found sporadic CJD to be significantly associated with surgical treatments 8 although another did not confirm this. 9 Although there is no complete consensus as to the nature of the agent which causes BSE and vCJD, there is general agreement that a corrupted form of a protein, prion (PrP), is at least a component of such an agent. The disease specific form of PrP, designated PrP Sc, has been found in the tonsils, spleens and lymph nodes of patients who have died from vCJD (and not in any of the same tissues from matched controls) 10 and in the appendix of a vCJD case extracted 1 year before the onset of illness 11 .…”

Section: B the Theoretical Risk Of Iatrogenic Transmission Of Vcjdmentioning

confidence: 99%

A quantitative assessment of residual protein levels on dental instruments reprocessed by manual, ultrasonic and automated cleaning methods

Vassey¹,

Budge²,

Poolman³

et al. 2011

Br Dent J

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“…Prion diseases afflict humans as well as livestock, such as cattle, goats, and sheep; additionally, prions cause CNS disease in captive and wild populations of deer and elk (51,53). In contrast to scrapie of sheep and goats, bovine spongiform encephalopathy (BSE) in cattle has been transmitted to humans and has killed more than 170 teenagers and young adults as variant Creutzfeldt-Jakob disease (vCJD) (44,49,51,52). BSE prions have been experimentally transmitted to sheep and appear to be transmitted naturally among sheep (6).…”

mentioning

confidence: 99%

Transmission of Elk and Deer Prions to Transgenic Mice

Tamgüney

Giles

Bouzamondo-Bernstein³

et al. 2006

J Virol

169

170

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Chronic wasting disease (CWD) is a fatal prion disease in deer and elk. Unique among the prion diseases, it is transmitted among captive and free-ranging animals. To facilitate studies of the biology of CWD prions, we generated five lines of transgenic (Tg) mice expressing prion protein (PrP) from Rocky Mountain elk (Cervus elaphus nelsoni), denoted Tg(ElkPrP), and two lines of Tg mice expressing PrP common to white-tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus), denoted Tg(DePrP). None of the Tg(ElkPrP) or Tg(DePrP) mice exhibited spontaneous neurologic dysfunction at more than 600 days of age. Brain samples from CWD-positive elk, white-tailed deer, and mule deer produced disease in Tg(ElkPrP) mice between 180 and 200 days after inoculation and in Tg(DePrP) mice between 300 and 400 days. One of eight cervid brain inocula transmitted disease to Tg(MoPrP)4053 mice overexpressing wild-type mouse PrP-A in ϳ540 days. Neuropathologic analysis revealed abundant PrP amyloid plaques in the brains of ill mice. Brain homogenates from symptomatic Tg(ElkPrP) mice produced disease in 120 to 190 days in Tg(ElkPrP) mice. In contrast to the Tg(ElkPrP) and Tg(DePrP) mice, Tg mice overexpressing human, bovine, or ovine PrP did not develop prion disease after inoculation with CWD prions from among nine different isolates after >500 days. These findings suggest that CWD prions from elk, mule deer, and white-tailed deer can be readily transmitted among these three cervid species.

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Case-control study of risk factors of Creutzfeldt-Jakob disease in Europe during 1993-95

Cited by 172 publications

References 25 publications

Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt– Jakob disease: Implications for human health

Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt– Jakob disease: Implications for human health

A quantitative assessment of residual protein levels on dental instruments reprocessed by manual, ultrasonic and automated cleaning methods

Transmission of Elk and Deer Prions to Transgenic Mice

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