Case definitions for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a systematic review

“…Fatigue persisting for less than six months, or fatigue attributable to an identified organic cause such as hypothyroidism, preclude the diagnosis of CFS [2]. Based on clinical assessment, the worldwide prevalence of CFS is 0.76% [3].…”

Section: Introductionmentioning

confidence: 99%

"Flowers" in the blood: A novel paired erythrocyte arrangement in a patient with chronic fatigue syndrome following infectious mononucleosis

Burdzinski¹

2014

IJCRI

View full text Add to dashboard Cite

International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. The presence of the erythrocyte pairs abated with the patient's recovery from chronic fatigue syndrome over a 24-month period. This erythrocyte arrangement has not been reported elsewhere in medical literature. Conclusion: A novel erythrocyte "flower" formation was identified in a patient with chronic fatigue syndrome. The presence of this arrangement paralleled the course of the illness and was no longer observed upon recovery. The physiological relevance of the structure remains a subject for future research. Several hypotheses are suggested, including enhanced membrane deformability resulting from elevated catecholamine levels, and immune-mediated agglutination, possibly stemming from viral infection. IJCRI publishes(This page in not part of the published article.)

show abstract

“…• Prevalence: Estimates of prevalence in adults vary widely, there are few good estimates of prevalence in children, and there are no well-characterized descriptions and estimates of the different levels of severity or of prevalence estimates broken down by disease severity [48]. A conservative estimate of prevalence, based on the most widely accepted study, has been used to best reflect what is known about the disease but this estimate could be either high or low.…”

Section: Limitationsmentioning

confidence: 99%

Estimating the disease burden of ME/CFS in the United States and its relation to research funding

Dimmock¹,

Mirin²,

Jason³

2016

J Med Therap

View full text Add to dashboard Cite

At the National Institutes of Health (NIH), burden of disease is an important factor in funding decisions along with such factors as scientific opportunity, the quality of the science, and the interest of researchers. Recent studies have quantified the burden for a number of diseases in the United States and the NIH has used that information to analyze how its own funding patterns correspond to disease burden. However, the burden of disease has not been quantified for myalgic encephalomyelitis, also called chronic fatigue syndrome (ME/CFS) and is often underestimated due to a lack of research and the misperceptions about the nature of the disease.Using the limited information in the literature, this paper develops a preliminary estimate of the disease burden of ME/CFS in the United States, using the World Health Organization's Disability Adjusted Life Years (DALY) measure. The ME/CFS DALY estimate is then compared to the NIH's 2013 analysis of research funding versus DALY across other funded diseases in order to estimate a level of funding for ME/CFS that would be commensurate with disease burden.Even given the limitations arising from sparse data, this analysis demonstrates that federal research funding for this disease is far less than what would be expected by the burden of the disease. We conclude that the annual research funding for ME/CFS would need to increase twenty-five fold or more to be commensurate with disease burden. This level of funding would best leverage the growing interest of researchers and the significant scientific opportunities that exist to understand the pathology of this disease and to advance diagnostics and treatments.

show abstract

Case definitions for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a systematic review

Cited by 219 publications

References 80 publications

Chronic Fatigue Syndrome: Case Definitions, Possible Causes, and Therapies

Chronic Fatigue Syndrome: Case Definitions, Possible Causes, and Therapies

"Flowers" in the blood: A novel paired erythrocyte arrangement in a patient with chronic fatigue syndrome following infectious mononucleosis

Estimating the disease burden of ME/CFS in the United States and its relation to research funding

Contact Info

Product

Resources

About