Case Detection Rates of Molluscum Contagiosum in Childhood

Kyriakis, Kyriakos P.; Παλαμάρας, Ιούλιος; Terzoudi, S; Emmanuelides, Smaro; Michailides, Charalambos

doi:10.1111/j.1525-1470.2007.00378.x

Cited by 15 publications

(11 citation statements)

References 6 publications

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“…Although, according to previous prevalence studies, the prevalence rate of erythematotelangiectatic rosacea is three times higher than that of papulopustular rosacea. and phymatous rosacea is a rare form (3,5), the respective rates established in the study were similar for non-seekers. This suggests that many subjects with erythema and telangiectasia regard their skin changes as a skin condition rather than a true skin disease and only the presence of inflammation stimulates patients to seek medical care.…”

Section: Discussionsupporting

confidence: 49%

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Subjective Disease Perception and Symptoms of Depression in Relation to Healthcare-seeking Behaviour in Patients with Rosacea

Abram¹,

Silm²,

Maaroos³

et al. 2009

Acta Derm Venerol

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Many patients with rosacea do not seek medical care. The aim of this study was to find predictors for healthcare-seeking behaviour among patients with rosacea. The study subjects were 70 consecutive patients attending a dermatologist (seekers) and 56 subjects with rosacea symptoms selected randomly from among the working population (non-seekers). All subjects completed an Estonian Mood Scale questionnaire, a screening instrument for depressive symptoms, and evaluated their subjective disease perception on a visual analogue scale (VAS). Multivariate analysis showed that the independent predictors for healthcare-seeking behaviour were VAS scores >5 and the presence of advanced forms of rosacea. Higher mean VAS scores were not related to severity of rosacea, but were associated with the presence of depressive symptoms among seekers. In conclusion, healthcare-seeking behaviour is associated with higher subjective disease perception. The presence of depressive symptoms is not related to severity of the disease, but to the subjective disease perception of rosacea patients.

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Section: Discussionsupporting

confidence: 49%

“…Population-based studies have found the prevalence rate of rosacea to be in the range 2-10% (2,3). Studies with patients of dermatology clinics have established the prevalence rate of rosacea to be 0.5-3% on the basis of referrals to various dennatology centres (4)(5)(6). This suggests that many patients with rosacea never seek medical care for their rosacea.…”

mentioning

confidence: 97%

Subjective Disease Perception and Symptoms of Depression in Relation to Healthcare-seeking Behaviour in Patients with Rosacea

Abram¹,

Silm²,

Maaroos³

et al. 2009

Acta Derm Venerol

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“…MCV infection is limited to keratinocytes, causing a persistent dermatological infection (molluscum contagiosum; MC) that results in the formation of benign self-limiting neoplasms (4). MC occurs worldwide (5, 6), and reports show 8–23% of humans test positive for anti-MCV antibodies (7, 8). Lesions can persist for 6–9 months in healthy individuals and can last for many years in immunocompromised individuals (4).…”

Section: Introductionmentioning

confidence: 99%

The MC159 Protein from the Molluscum Contagiosum Poxvirus Inhibits NF-κB Activation by Interacting with the IκB Kinase Complex

Randall

Jokela

Shisler

2012

The Journal of Immunology

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Molluscum contagiosum virus (MCV) causes persistent neoplasms in healthy and immunocompromised people. Its ability to persist likely is due to its arsenal of viral immune evasion proteins. For example, the MCV MC159 protein inhibits TNFR1-induced NF-κB activation and apoptosis. The MC159 protein is a viral FLIP and, as such, possesses two tandem death effector domains (DEDs). We show here that, in HEK293T cells, the expression of wild-type MC159 or a mutant MC159 protein containing the first DED (MC159 A) inhibited TNF-induced NF-κB, or NF-κB activated by PMA or MyD88 over-expression, whereas a mutant protein lacking the first DED (MC159 B) did not. We hypothesized that the MC159 protein targeted the IKK complex to inhibit these diverse signaling events. Indeed, the MC159 protein, but not MC159 B, co-immunoprecipitated with IKKγ. MC159 co-immunoprecipitated with IKKγ when using MEFs lacking either IKKα or IKKβ, suggesting that the MC159 protein interacted directly with IKKγ. MC159-IKKγ co-immunoprecipitations were detected during infection of cells with either MCV isolated from human lesions or with a recombinant MC159-expressing vaccinia virus. MC159 also interacts with TRAF2, a signaling molecule involved in NF-κB activation. However, mutational analysis of MC159 failed to reveal a correlation between MC159-TRAF2 interactions and MC159’s inhibitory function. We propose that MC159-IKK interactions, but not MC159-TRAF2 interactions, are responsible for inhibiting NF-κB activation.

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“…Molluscum contagiosum is caused by a poxvirus and most commonly causes disease in childhood with a peak incidence between 2 and 5 years of age [43]. Lesions are seen quite commonly on the genital, perineal and surrounding skin of children, and although theoretically could be transferred through sexual abuse, this should not be considered as likely unless there are other suspicious features [40].…”

Section: Molluscum Contagiosummentioning

confidence: 99%