Case files of the medical toxicology fellowship at the New York City Poison Control: Bromism: Forgotten, but not gone

Lugassy, Daniel; Nelson, Lewis S.

doi:10.1007/bf03161228

Cited by 24 publications

(26 citation statements)

References 27 publications

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“…Bromide has been used medically for decades . Bromides are divided into two types: inorganic and organic agents.…”

Section: Discussionmentioning

confidence: 99%

“…Inorganic agents such as potassium bromide and sodium bromide are used mainly for the treatment of epilepsy . The organic agents are bromoureides such as bromvalerylurea, bromisovalerylurea and bromdiethylacetylurea . Bromoureides were previously popular as sedative‐hypnotics .…”

Section: Discussionmentioning

confidence: 99%

“…The organic agents are bromoureides such as bromvalerylurea, bromisovalerylurea and bromdiethylacetylurea . Bromoureides were previously popular as sedative‐hypnotics . These medical bromides were widely used from the late 19th to the early 20th century, and many cases of intoxication (bromism) and bromoderma were reported during that period .…”

Section: Discussionmentioning

confidence: 99%

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Bromoderma mimicking pyoderma gangrenosum caused by commercial sedatives

Oda

Tohyama

Murakami

et al. 2015

The Journal of Dermatology

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Bromoderma is a rare skin disorder caused by bromide intake. It presents as single or multiple papillomatous nodules or plaques, and ulcers studded with small pustules on the face or limbs. The clinical features of bromoderma are similar to those of pyoderma gangrenosum. A 41-year-old Japanese woman was diagnosed with pyoderma gangrenosum 11 years prior to presentation. Pyoderma had repeatedly appeared over her entire body despite treatment. She also frequently complained of syncopal episodes. She was admitted to our hospital after loss of consciousness and an episode of generalized convulsion. Laboratory tests revealed a negative serum anion gap and hyperchloremia. Her serum bromide level was significantly elevated, suggesting bromide intoxication. The patient had a 10-year history of high serum bromide levels. After the intake of bromide-containing sedatives was stopped, there was no recurrence of pyoderma in the absence of treatment. In conclusion, this case was diagnosed as bromoderma with commercial sedative-induced bromide intoxication. Although the US Food and Drug Administration have banned the use of bromides, over-the-counter (OTC) treatments containing bromides are still used in Japan and other countries. Long-term use of OTC medicines containing bromvalerylurea may result in the development of bromoderma. If unclarified neurological or psychiatric symptoms are associated with pyoderma, we propose measurement of the patient's serum chloride concentration. Determination of hyperchloremia is helpful for the diagnosis of chronic intoxication with bromides.

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“…Bromide has been used medically for decades . Bromides are divided into two types: inorganic and organic agents.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bromoderma mimicking pyoderma gangrenosum caused by commercial sedatives

Oda

Tohyama

Murakami

et al. 2015

The Journal of Dermatology

View full text Add to dashboard Cite

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“…These conditions have been characterised by the symptoms of lethargy, neurological disorders in adults as a result of excessive ingestion or exposure to bromide-containing products (110)(111)(112)(113). A study reporting the outcome of 64 patients diagnosed with psoriasis and the topical application of a naturally high mineralised bromine-iodine brine found some interesting results.…”

Section: Bromine (Br)mentioning

confidence: 99%

“…Historically, studies have concentrated on reporting the toxicity of bromine in humans which include methylbromide toxicity and bromism, characterised by the symptoms of lethargy, neurological disorders in adults as a result of excessive ingestion or through exposure to bromide-containing products (110)(111)(112)(113). Consequently, it is suggested that the essentiality of bromine has been previously overlooked.…”

Section: Introductionmentioning

confidence: 99%