Case History Data and Prognosis in Schizophrenia

Effect of Pimozide on Positive and Negative Symptoms in Schizophrenic Patients: Are Negative Symptoms State Dependent?

“…The Spearman corre lations between change in thought disorder and these items were as follows: emotional withdrawal, r= 0.61, p < 0.03; motor retardation, r = 0.60, p < 0.04; blunted affect, r = 0.57, p < 0.05. There were no significant differences between the responder and nonresponder groups regarding age, num ber of Schneiderian first-rank symptoms, duration of ill ness, pimozide dosage and premorbid social functioning as measured by the Phillips [15] score (table II). How ever, the neuroleptic responder group had a significantly higher score on the BPRS withdrawal-retardation cluster than did the nonresponders before beginning pimozide treatment (table II).…”

Gender differences in the prediction of 5‐year outcome in first episode psychosis

“…The PRS showed promising results in assessing those at a risk of an unfavourable outcome (Flyckt et al, 2006). It is well known that males and females differ regarding age at onset, clinical features and outcome of psychosis (Foerster et al, 1991;Hafner, 2003;Lindamer et al, 2003;Preston et al, 2002;Salokangas et al, 2003;Usall et al, 2003) but this has not been suffi ciently taken into account by the predictive scales available today (Phillips, 1953;Stephens et al, 1997;Strauss and Carpenter, 1974;Vaillant, 1964). Therefore, we have considered it important to examine whether the PRS had an equally promising predictive potential for both genders.…”

Associative interference and premorbid adjustment in schizophrenia.

“…Premorbid Adjustment in Schizophrenia (Phillips, 1953; DeWolfe, 1968). Those scoring 12 or below on the scale were considered to be good premorbids and those scoring 18 or above were considered to be poor premorbids.…”