“…Study population size varied widely, ranging from seven participants to over 100,000. Fifteen studies had a study population of less than 100 [ 14 , 26 , 30 , 34 , 36 , 41 , 44 , 47 , 51 , 57 , 62 , 65 , 66 , 68 , 71 ], 24 had a study population of 100–500 [ 15 , 16 , 27 , 28 , 32 , 33 , 38 , 40 , 42 , 43 , 48 – 50 , 53 , 55 , 58 – 61 , 63 , 67 , 72 , 77 , 79 ], six had a study population of 500–1,000 [ 31 , 45 , 64 , 74 , 78 , 80 ], and 13 had a study population of more than 1,000 [ 18 , 29 , 36 , 37 , 39 , 46 , 52 , 54 , 56 , 69 , 70 , 75 , 76 ], Fig. 2 .…”