Case of anaphylaxis caused by black ginger in a dietary supplement

Hayashi, Eriko; Sowa‐Osako, Junko; Fukai, Kazuyoshi; Natsumi, Aki; Yagami, Akiko; Sato, Norikazu; Shimojo, Naoshi; Nakamura, Masashi; Matsunaga, Kayoko; Tsuruta, Daisuke

doi:10.1111/1346-8138.14592

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…In order to confirm that fish collagen was the antigen responsible for the patient's fish allergy, immunoblotting was performed to determine whether her serum contained IgE antibodies to the fish collagen in the gummy tablets and to commercially available pork gelatin by the method of Hayashi et al [ 10 ] ( Fig. 1 ).…”

Section: Case Reportmentioning

confidence: 99%

A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen

Ueno¹,

Takaoka²,

Shimojo

et al. 2020

Asia Pacific Allergy

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Fish collagen is one of the major allergens involved in fish allergies; however, it has not been well-established whether fish collagen can cause anaphylaxis among individuals with fish allergies, especially children. A 9-year-old girl experienced anaphylaxis after consuming 2 fruit-flavored gummy tablets. Contacting the manufacturing company revealed that fishderived collagen was used in the gummy tablets, and an oral fish collagen challenge test confirmed that the anaphylaxis was induced by fish collagen. Immunoblot analysis showed a 120-kDa band in a sample of the fish collagen in the gummy tablets, and no reactive band of the pork gelatin was observed. Additionally, salmon collagen and other fish samples that provoked symptoms were detected as a 120-kDa band in the immunoblot analysis. The 120-kDa band was identified as fish collagen by mass spectrometry confirming that it was the causative antigen of our patient's allergy. This case study confirms that fish collagen can cause anaphylaxis in children with fish allergies. Physicians and allergic individuals need to be aware that processed foods may contain fish collagen to avoid allergic reactions.

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Section: Case Reportmentioning

confidence: 99%

A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen

Ueno¹,

Takaoka²,

Shimojo

et al. 2020

Asia Pacific Allergy

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“…46 There are reports of anaphylaxis related to ginger use; however, it appears to be exceedingly rare. 47,48 Future research…”

Section: Side Effectsmentioning

confidence: 99%

Clinical dermatologic applications of ginger: a focused review

Alhanshali,

Khachemoune

2023

Int J Dermatology

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Ginger is a traditional herb with medicinal properties. Although most commonly utilized as a spice, it has been used for various medicinal ailments for thousands of years. Over the past century, the anti‐inflammatory, antioxidative, and antimicrobial properties of ginger have been increasingly studied. Ginger has been demonstrated to be beneficial for many conditions including dermatologic, gastrointestinal, neoplastic, and respiratory diseases. Herein, we examine the existing literature regarding the clinical uses of ginger with a focus on its dermatologic applications.

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“…Akagawa et al [21] characterized wheat allergens using two-dimensional Western blotting (2D-WB), a methodology that combines 2D-PAGE and immunoblotting. Previously, we also extensively used 2D-WB to identify and characterize allergens responsible for a variety of immediate-type allergic reactions [22][23][24][25][26][27][28][29][30][31][32]. However, no studies have focused on antibody markers specific to ω-5 gliadin sIgE-negative WDEIA.…”

Section: Introductionmentioning

confidence: 99%

Alpha/Beta Gliadin MM1 Is a Novel Antigen for Wheat-Dependent Exercise-Induced Anaphylaxis

Aoki

Yagami

Sakai

et al. 2023

Int Arch Allergy Immunol

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Introduction: Screening for ω-5 gliadin specific IgE antibody (sIgE) has high diagnostic utility in cases of suspected wheat-dependent exercise-induced anaphylaxis (WDEIA); however, negative cases may require confirmatory tests, such as the oral challenge test. Thus, newly identified allergens that can be used for the serological diagnosis of WDEIA are needed. This study aimed to identify additional sIgE biomarkers of WDEIA. Methods: Forty-two patients with WDEIA (5 negative/37 positive for ω-5 gliadin sIgE) were enrolled. For comparison, 8 patients with immediate-type wheat allergy without WDEIA and 20 healthy controls without wheat allergy were also enrolled. Extracted wheat proteins were separated by 2D-PAGE. Proteins that reacted with serum IgE antibody in 2D Western blotting (2D-WB) were identified using mass spectrometry. Recombinant proteins were synthesized in Escherichia coli, and the antigenicity was tested using ELISA and the basophil activation test. Results: In 2D-WB, nine proteins reacted with the serum IgE antibody from at least 60% of patients with WDEIA (n ≥ 25/42). ELISA revealed that alpha/beta gliadin MM1 exhibited the highest positive immunoreactivity in 23 of 26 patients who were positive for ω-5 gliadin sIgE (88%) and in 5 of 5 patients who were negative for ω-5 gliadin sIgE (100%). Alpha/beta gliadin MM1 exhibited significantly higher basophil activation in 14 patients with WDEIA when compared to 5 individuals without a wheat allergy. Conclusions: Alpha/beta gliadin MM1 sIgE exhibited the highest seropositivity, even among patients who were negative for ω-5 gliadin sIgE. The inclusion of alpha/beta gliadin MM1 in allergen-sIgE tests may improve the sensitivity for diagnosing WDEIA.

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Case of anaphylaxis caused by black ginger in a dietary supplement

Cited by 5 publications

References 4 publications

A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen

A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen

Clinical dermatologic applications of ginger: a focused review

Alpha/Beta Gliadin MM1 Is a Novel Antigen for Wheat-Dependent Exercise-Induced Anaphylaxis

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