Case of colonic mucosal Schwann cell hamartoma and review of literature on unusual colonic polyps

Abstract

Mucosal Schwann cell hamartomas (MSCH) are benign mesenchymal tumours rarely seen in the gastrointestinal tract. They occasionally present as incidental sessile polyps during colonoscopy. A 55-year-old asymptomatic female patient with a medical history of multiple sclerosis presented for a screening colonoscopy. A 5 mm low-risk tubular adenoma was noted in the caecum, and a second 5 mm polyp was found in the ascending colon. Histopathology of the ascending colon polyp showed proliferation of spindle cells without ganglion cells in the lamina propria. Immunohistochemical findings are compatible with an MSCH. Surveillance colonoscopy was scheduled in 5 years based on the presence of a single low-risk tubular adenoma.

An Unusual Case of Schwann Cell Hamartoma in Colon

“…Sagami et al reported a case of MSCH in 2012, which was diagnosed after the presentation of anemia and a positive fecal occult blood test [6]. The literature review endorsed some MSCH polyps that have been detected in the colon during an incidental screening colonoscopy and confirmed by histopathological features with the presence of pure Schwann cell proliferation in the lamina propria and show diffuse immunoreactivity for the S-100 protein [7][8][9][10][11]. Moreover, in 2013, Neis et al reported a case of MSCH in an ulcerative colitis patient with primary sclerosing cholangitis during routine screening [12].…”

Mucosal Schwann cell hamartoma: a benign and little-known entity

“…MSCH are benign and intramucosal tumors with a mesenchymal origin (1). They are most commonly located in the distal colon, but they were also found in the gallbladder, the esophagogastric union and in the antrum.…”

Multiple Gastric Antrum Mucosal Schwann Cell Hamartoma on Incidental Screening Gastroscopy: A Case Report

“…MSCHs of the GI tract are rare benign lesions, which were different from other neural tumors [1]. Recently, a few cases in colon and rectum [5][6][7][8], GEJ [2] , stomach [4] and gallbladder [3] have been reported successively. The literatures showed there was a slight female predominance and most often occur in elder people.…”