2022
DOI: 10.5415/apallergy.2022.12.e37
|View full text |Cite
|
Sign up to set email alerts
|

Case of hypereosinophilic syndrome with gastrointestinal involvement showing tissue eosinophil cytolysis

Abstract: Hypereosinophilic syndrome (HES), which is characterized by eosinophilia in the peripheral blood, often causes various organ disorders, including those of the gastrointestinal (GI) tract. The eosinophils play a key role in inflammation in eosinophilic GI disorders (EGIDs), including HES with GI involvement. Here, we report a case of HES with GI involvement that showed major basic proteins (MBPs) deposition in the absence of marked eosinophilic infiltration in the mucosa of the GI tract. An 11-year-old boy pres… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
2
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(2 citation statements)
references
References 17 publications
0
2
0
Order By: Relevance
“…However, it should be noted that some markers are not only found in eosinophils with EETosis but can also be released by apoptotic or necrotic eosinophils and other cells, so it is worth considering how to combine and detect these markers. Visualization of EETs production by cellular immunofluorescence or immunohistochemistry is the most accurate method [ 64 66 ], but this is relatively inaccessible in asthmatic patients because it requires obtaining BALF and lung tissue samples in an invasive manner, such as bronchoscopy.…”
Section: Eets As Biomarkersmentioning
confidence: 99%
“…However, it should be noted that some markers are not only found in eosinophils with EETosis but can also be released by apoptotic or necrotic eosinophils and other cells, so it is worth considering how to combine and detect these markers. Visualization of EETs production by cellular immunofluorescence or immunohistochemistry is the most accurate method [ 64 66 ], but this is relatively inaccessible in asthmatic patients because it requires obtaining BALF and lung tissue samples in an invasive manner, such as bronchoscopy.…”
Section: Eets As Biomarkersmentioning
confidence: 99%
“…Readers will also find nice original articles such as a 5-year longitudinal study on the Melbourne epidemic thunderstorm asthma event 2016 [ 7 ], natural history and clinical course of patients with dermographism in a tropical country [ 8 ], how physicians approach hereditary angioedema [ 9 ], a study on anaphylaxis after Coronavac vaccination in healthcare workers [ 10 ], the level of knowledge among healthcare professionals regarding anaphylaxis [ 11 ], identification of fungi causing humidifier lung [ 12 ], and the measures for food allergy emergency in nurseries [ 13 ]. Reader will be interested in the case reports such as a clindamycin graded challenge in an AIDS patient [ 14 ], a case of hypereosinophilic syndrome with gastrointestinal involvement showing tissue eosinophil cytolysis [ 15 ], and severe chronic cough relating to post-COVID-19 interstitial lung disease [ 16 ].…”
mentioning
confidence: 99%