Case of idiopathic loss of deciduous teeth and associated alveolus

Oral ulceration with bone sequestration: Retrospective study of eight cases and literature review

“…Literature review yielded 16 eligible original studies reporting 32 cases of OUBS, on June 15, 2018 (Table ). We excluded a conference abstract (Koshal, Chaudhry, Johnson, & Porter, ); two reviews (Farah & Savage, ; Palla et al, ); two case reports that we could not access (Danesh‐Meyer, ; Dhanrajani, ); two cases of bone sequestration developing in the interdental bone between upper molars due to the habitual use of a metallic pin (Aamir & Mandroli, ) or a toothpaste allergy (Sonnier & Horning, ), respectively, as they did not develop on a prominence of the jawbones; a case report of an ulcerated torus mandibularis, where the underlying bone was proved microscopically to be vital (Manganaro, Faulk‐Eggleston, Schanzer, & Dagostino, ); and three cases in patients medicated with drugs that may induce medication‐related osteonecrosis of the jaws (MRONJ) (Abel Mahedi Mohamed, Nielsen, & Schiodt, ; Aghaloo & Tetradis, ; Tezuka & Tanaka, ), as it is not possible to exclude that they may represent examples of spontaneous MRONJ. In contrast, we included a patient that developed bone sequestration two days after an intravenous infusion for the first time of 4 mg zoledronic acid (Almazrooa et al, ), as the short time interval makes the possibility of MRONJ improbable (Favia, Tempesta, Limongelli, Crincoli, & Maiorano, ; Katz & Ordoveza, ).…”

“…In a recent systematic review of the English literature, Palla et al () found 24 cases of OUBS. However, they included patients medicated with drugs known to induce MRONJ (Abel Mahedi Mohamed et al, ; Aghaloo & Tetradis, ), such as alendronic acid (Jackson & Malden, ), prednisone, and methotrexate (Flaitz, ), while one case was in the form of a conference abstract (Koshal et al, ).…”

“…Symptoms (Table 1). We excluded a conference abstract (Koshal, Chaudhry, Johnson, & Porter, 2010); two reviews (Farah & Savage, 2003;Palla et al, 2016); two case reports that we could not access (Danesh-Meyer, 1999;Dhanrajani, 2008); Aghaloo & Tetradis, 2017), such as alendronic acid (Jackson & Malden, 2007), prednisone, and methotrexate (Flaitz, 2000), while one case was in the form of a conference abstract (Koshal et al, 2010). As it is seen in Table 1, the demographical data, anatomic location, duration, and symptomatology of the eight cases presented herein are in accordance with those of previously reported cases of OUBS.…”