Case of Incomplete Kawasaki Disease with No Symptoms Except Fever Causing the Development of Coronary Aneurysm

Uchida, Yuta; Iwamoto, Yoichi; Urushihara, Yasuko; Nagura, Michiaki; Tanaka, Risa; Arakawa, Hiroshi; Ishido, Hirotaka; Moriwaki, Koichi; Masutani, Satoshi

doi:10.1536/ihj.18-647

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…However, nationwide surveys have shown that the incidence of CAA development in Japan has not changed substantially in recent years (2013-2014: CAAs, 2.6%; and giant aneurysms, 0.20%; 2015-2016: CAAs, 2.3%; and giant aneurysms, 0.13%; and 2017-2018: CAAs, 2.6%; and giant aneurysms, 0.11%). Additionally, in clinical practice, some patients with CAAs show resolution of fever with initial IVIG therapy or naturally without treatment . Thus, even if effective treatments for immunoglobulin-refractory KD are established, the development of KD-related CAAs cannot always be prevented.…”

Section: Introductionsupporting

confidence: 76%

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Analysis of Age, Sex, Lack of Response to Intravenous Immunoglobulin, and Development of Coronary Artery Abnormalities in Children With Kawasaki Disease in Japan

et al. 2022

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Key Points Question Are age and sex associated with unresponsiveness to intravenous immunoglobulin (IVIG) and the development of coronary artery abnormalities (CAAs) among patients with Kawasaki disease (KD)? Findings This cohort study using data from 2414 patients in Japan identified an association between the proportion of patients with initial unresponsiveness to IVIG and increasing age. Differences in the risk factors were observed between initial unresponsiveness to IVIG and the development of CAAs in infants with KD. Meaning This study suggests that residual risks other than initial unresponsiveness to IVIG must be addressed to prevent CAA complications among patients with KD, particularly in infants.

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Section: Introductionsupporting

confidence: 76%

“…Additionally, in clinical practice, some patients with CAAs show resolution of fever with initial IVIG therapy or naturally without treatment. 16 , 17 , 18 , 19 , 20 , 21 Thus, even if effective treatments for immunoglobulin-refractory KD are established, the development of KD-related CAAs cannot always be prevented.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Age, Sex, Lack of Response to Intravenous Immunoglobulin, and Development of Coronary Artery Abnormalities in Children With Kawasaki Disease in Japan

et al. 2022

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An Update on Reports of Atypical Presentations of Kawasaki Disease and the Recognition of IVIG Non-Responder Children

et al. 2023

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Kawasaki disease (KD) is an acute vasculitis with an intrinsic risk of severe involvement of coronary arteries. The worldwide spread of KD and the importance of early diagnosis for preventing cardiovascular complications have ascertained the need for updating guidelines for prompt disease recognition and treatment efficacy assessment. All KD patients who comply with the definition of classic or atypical disease should be treated with intravenous immunoglobulin (IVIG) soon after diagnosis. The objective of our narrative review was to analyze the medical literature about case reports with atypical KD in relation to diagnosis and potential identification of predictors of non-responsiveness to IVIG. Our analysis has shown that the seminal challenge in KD management is the timeliness of diagnosis, although both extreme variability and transience of clinical manifestations make this goal difficult. A non-negligible percentage of patients, especially in the first 6 months of life, might have atypical manifestations of KD, whose painstaking differential diagnosis may be tricky. Many attempts to develop universal scoring systems and detect children at higher risk of IVIG resistance have been rather unsuccessful. Additionally, KD may show different evolutions according to unraveled demographic, genetic, or epigenetic factors. Further research is needed to elucidate all open questions about KD and clarify the long-term outcome of its potential complications.

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Doença de Kawasaki Incompleta Diagnosticada Apenas com Febre Prolongada: Relato de Dois Casos e Revisão da Literatura

Kiztanir,

Sulu,

Kosger

et al. 2024

Arq. Bras. Cardiol.

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Case of Incomplete Kawasaki Disease with No Symptoms Except Fever Causing the Development of Coronary Aneurysm

Cited by 5 publications

References 11 publications

Analysis of Age, Sex, Lack of Response to Intravenous Immunoglobulin, and Development of Coronary Artery Abnormalities in Children With Kawasaki Disease in Japan

Analysis of Age, Sex, Lack of Response to Intravenous Immunoglobulin, and Development of Coronary Artery Abnormalities in Children With Kawasaki Disease in Japan

An Update on Reports of Atypical Presentations of Kawasaki Disease and the Recognition of IVIG Non-Responder Children

Doença de Kawasaki Incompleta Diagnosticada Apenas com Febre Prolongada: Relato de Dois Casos e Revisão da Literatura

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