Case of isolated Rhizobium radiobacter contact lens-related infectious keratitis: A plant microbe now emerging as a human pathogen

Fenner, Beau J.; Kumar, Ashish; Tan, Nicholas Y.Q.; Ang, Marcus

doi:10.1016/j.ajoc.2019.100476

Cited by 10 publications

(6 citation statements)

References 26 publications

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“…Recently, A. radiobacter was isolated from the blood of children with limited immunity, especially those with venous catheters suffering from acute lymphoblastic ____________________________________________________________________________________________________________________ leukemia (Mantadakis et al 2010). In turn, Fenner et al (2019) described a case of R. radiobacter infection of cornea in humans wearing contact lenses. The authors pointed out that this is the case of monomicrobial R. radiobacter keratitis, thus adding to the sparse literature information on this uncommon but potentially sight-threatening infection.…”

Section: Bacterial Plant Pathogens Sharing Plant and Human Hostsmentioning

confidence: 99%

Plant and Human Pathogenic Bacteria Exchanging their Primary Host Environments

Sobiczewski

Iakimova²

2022

Journal of Horticultural Research

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Adaptation of plant and human pathogenic bacteria to niches of existence differing from their original ones is a sophisticated mechanism for survival. Research indicates that certain plant bacterial pathogens are capable of causing disease in humans, and some human bacterial pathogens can inhabit the plant environment and cause disease in plants. The infection of humans by plant bacteria may occur at direct physical contact with diseased plants and/or via the respiratory tract in mainly immunocompromised or otherwise stressed individuals. Indirect transmitters of plant and human microbes can be wind, rain, dust, insects, and animals. Human pathogenic bacteria may contaminate the soil and irrigation water, colonize the rhizosphere, more rarely also the phyllosphere, and can survive as epiphytes. Thus, the plant environment may become a reservoir of human pathogens. A source of foodborne human pathogenic bacteria can be unprocessed or unwashed fruits and vegetables. Especially during the last decade, the processes underlying the cross-kingdom performance of pathogenic bacteria are intensively researched. However, in reality, the risk for human health at infections by plant bacteria and by human bacterial pathogens surviving in the plant environment is still underestimated. The goal of the current review is to increase the interest in these issues in agricultural and general environments. Some basic strategies for infection and symptoms of diseases caused by the microorganisms under consideration are described. The potency of certain plant bacterial pathogens to surpass barriers towards humans and the interaction of human bacterial pathogens with the plant environment are addressed and the existing information is critically discussed.

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Section: Bacterial Plant Pathogens Sharing Plant and Human Hostsmentioning

confidence: 99%

Plant and Human Pathogenic Bacteria Exchanging their Primary Host Environments

Sobiczewski

Iakimova²

2022

Journal of Horticultural Research

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“…All cases had a favorable evolution, with total sight recovery. Furthermore, Fenner et al [ 36 ] reported keratitis in a young patient who was a contact lens wearer.…”

Section: Systematic Reviewmentioning

confidence: 99%

A Rare Case of Endophthalmitis with Rhizobium radiobacter, Soon after a Resolved Keratitis: Case Report

et al. 2022

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Background: Rhizobium (Agrobacterium) species are plant aerobic bacteria, which in some cases can produce endophthalmitis in humans after corneal trauma. Case presentation: A 42-year-old female patient presented in the Emergency Department of the Emergency County Hospital of Craiova, Romania, reporting pain, epiphora, and blurry vision in her right eye for about five days. This initial infectious keratitis episode was successfully resolved, but after 20 days she presented again after trauma with a leaf with corneal abscess. In the conjunctival secretion, R. radiobacter was identified. Despite antibiotherapy, the patient’s state did not improve, and ultimately the eye was eviscerated. Methods: A search was performed in the ProQuest, PubMed, and ScienceDirect databases for the terms Agrobacterium, Rhizobium, radiobacter, and eye. We eliminated non-human studies, editorials and commentaries, and non-relevant content, and excluded the duplicates. Results: In total, 138 studies were initially obtained, and then we selected 26 studies for retrieval. After the selection process, we ended up including 17 studies in our analysis. Most studies reported R. radiobacter endophthalmitis after ocular surgical procedures or outdoor activities that involve exposure to soil. Conclusion: R. radiobacter is a rare cause of endophthalmitis after eye trauma that generally responds well to usual antibiotherapy, but occasionally can evolve to severe, leading to the loss of the eye.

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“…Infections caused by these bacteria include bacteraemia, peritonitis and urinary tract infections, and they have been frequently associated with the use of intravascular devices in immunocompromised patients [ 335 , 336 , 337 ]. Further, A. radiobacter has been recently described to cause ocular infections, and it was identified in polymicrobial keratitis cases [ 338 ]. Although there is not much information about the intrinsic AR of these bacteria, the presence of RND efflux pumps in the genus Agrobacterium [ 339 , 340 ] suggests that these bacteria may present low susceptibility to different drugs.…”

Section: Emerging Opportunistic Pathogens With Environmental Originmentioning

confidence: 99%

Coming from the Wild: Multidrug Resistant Opportunistic Pathogens Presenting a Primary, Not Human-Linked, Environmental Habitat

Sanz-García

Gil-Gil

Laborda

et al. 2021

IJMS

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The use and misuse of antibiotics have made antibiotic-resistant bacteria widespread nowadays, constituting one of the most relevant challenges for human health at present. Among these bacteria, opportunistic pathogens with an environmental, non-clinical, primary habitat stand as an increasing matter of concern at hospitals. These organisms usually present low susceptibility to antibiotics currently used for therapy. They are also proficient in acquiring increased resistance levels, a situation that limits the therapeutic options for treating the infections they cause. In this article, we analyse the most predominant opportunistic pathogens with an environmental origin, focusing on the mechanisms of antibiotic resistance they present. Further, we discuss the functions, beyond antibiotic resistance, that these determinants may have in the natural ecosystems that these bacteria usually colonize. Given the capacity of these organisms for colonizing different habitats, from clinical settings to natural environments, and for infecting different hosts, from plants to humans, deciphering their population structure, their mechanisms of resistance and the role that these mechanisms may play in natural ecosystems is of relevance for understanding the dissemination of antibiotic resistance under a One-Health point of view.

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Case of isolated Rhizobium radiobacter contact lens-related infectious keratitis: A plant microbe now emerging as a human pathogen

Cited by 10 publications

References 26 publications

Plant and Human Pathogenic Bacteria Exchanging their Primary Host Environments

Plant and Human Pathogenic Bacteria Exchanging their Primary Host Environments

A Rare Case of Endophthalmitis with Rhizobium radiobacter, Soon after a Resolved Keratitis: Case Report

Coming from the Wild: Multidrug Resistant Opportunistic Pathogens Presenting a Primary, Not Human-Linked, Environmental Habitat

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