Case of Klinefelter’s syndrome in an 18 year old male presented with antisocial personality disorder

Annagür, Bılge Burçak; Kandeğer, Ali

doi:10.5350/dajpn2014270309

Cited by 2 publications

(3 citation statements)

References 14 publications

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“…How generalizable is this tendency? This patient's antisocial personality disorders (involving passive-aggressive tendencies, criminal behavior, and paraphilia) have been linked to KS, but this clinical history seems scarcely generalizable [32]. Given that Klinefelter Syndrome involves a low libido condition hypersexual desire in this patient appears very unusual.…”

Section: Identity Cards Of Couples With Ks Syndrome and Their Partnersmentioning

confidence: 83%

Klinefelter: Which Sexuality?

Longhi,

Salonia,

Montorsi

2023

J Sex Med Res

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Klinefelter syndrome (KS) was described by Klinefelter, Reifenstein, and Albright in 1942, who described 9 adult males with gynecomastia, small and firm testes, azoospermia, and increased serum FSH with functional Leydig cells. In 1959, using cytogenetics, Jacobs and Strong described the existence of an extra X chromosome in a male with Klinefelter syndrome The International Consensus Conference organized by the Lawson Wilkins Pediatric Endocrine Society and the European Society for Pediatric Endocrinology in 2006 included KS in disorders of sexual development. Klinefelter syndrome is also characterized by a genetic dysfunction of the entire gonad that affects germ cells from early fetal life and Sertoli and Leydig cells from mid-puberty. Today we know much more. In this article, we have delved into the social, relational, and sexual quality of life of patients with KS, going beyond fertility studies.

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Section: Identity Cards Of Couples With Ks Syndrome and Their Partnersmentioning

confidence: 83%

Klinefelter: Which Sexuality?

Longhi,

Salonia,

Montorsi

2023

J Sex Med Res

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“…In neuropsychological testing KS subjects consistently perform poorly in verbal skills ( 1 , 2 ). Behavioural and psychiatric disorders, including autism, attention deficit hyperactivity disorder, bipolar affective disorders and schizophrenia have been believed to be overrepresented in KS individuals; however the evidence base indicative of increased major psychiatric illness in KS is poor ( 1 , 2 , 3 , 4 , 5 ). The learning difficulties and autism features present early, suggesting that they are independent of testosterone deficiency.…”

Section: Discussionmentioning

confidence: 99%

“…The patient described here displayed anti-social behaviour once at the age of 17 and it involved a sexual offence involving a minor. Anti-social personality disorders resulting in passive-aggressive tendencies, criminal behaviours and interestingly paraphilia have been linked to KS, but this has been questioned due to poor-quality evidence ( 2 , 3 , 4 , 5 ). However, KS is a condition classically associated with low libido due to hypogonadism ( 6 ).…”

Section: Discussionmentioning

confidence: 99%

A case of Klinefelter syndrome with hypersexual desire

Okolie

Perampalam

Barker³

et al. 2017

Endocrinology, Diabetes &Amp; Metabolism Case Reports

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Klinefelter syndrome (KS) is a chromosomal disorder affecting males, with the typical karyotype of 47,XXY due to a supernumerary X chromosome, which causes progressive testicular failure resulting in androgen deficiency and infertility. Despite it being the most common sex chromosomal disorder, its diagnosis is easily missed. In addition to its classical clinical features of tall stature, gynaecomastia, small testes, and symptoms and signs of hypogonadism including infertility, KS is also often associated with neurocognitive, behavioural and psychiatric disorders.We present a 44-year-old man with KS who, despite having erectile dysfunction, paradoxically had increased libido. He used sildenafil to overcome his erectile dysfunction. Hypersexuality was manifested by very frequent masturbation, multiple sexual partners most of whom were casual, and a sexual offence conviction at the age of 17 years.Discussion focuses on the frequent failure of clinicians to diagnose KS, the neurocognitive, behavioural and psychiatric aspects of KS, this unusual presentation of hypersexuality in a man with KS, and the challenges of medical management of hypogonadism in a man with a history of a sexual offence.Learning points:Klinefelter syndrome (KS) is common in men (about 1 in 600 males), but the diagnosis is very often missed.In addition to classic features of hypogonadism, patients with KS can often have associated neurocognitive, behavioural and/or psychiatric disorders.More awareness of the association between KS and difficulties related to verbal skills in boys could improve rates of early diagnosis and prevent longer-term psychosocial disability.Hypersexuality in the context of hypogonadism raises the possibility of sex steroid independent mechanistic pathways for libido.Testosterone replacement therapy in KS with hypersexuality should be undertaken with caution using a multidisciplinary team approach.

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Case of Klinefelter’s syndrome in an 18 year old male presented with antisocial personality disorder

Cited by 2 publications

References 14 publications

Klinefelter: Which Sexuality?

Klinefelter: Which Sexuality?

A case of Klinefelter syndrome with hypersexual desire

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