Case of miliaria rubra histologically showing neutrophilic eccrine hidradenitis due to hyperhidrosis induced by a catecholamine‐producing neuroblastoma

Katayama, Sho; Iwata, Hiroaki; Nomura, Yukiko; Nakamura, Akie; Yamaguchi, Takeshi; Hishimura, Nozomi; Nakayama, Kanako; Hashimoto, Kimio; Honda, Susumu; Shimizu, Hiroshi

doi:10.1111/1346-8138.15224

Cited by 1 publication

(1 citation statement)

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“…The blueberry muffin rash and isolated cutaneous nodules indicate cutaneous metastasis [22]. Other rare cutaneous presentations have been described, including skin lesions mimicking miliaria rubra [23] and infantile hemangiomas [24]. Both cases illustrate the importance of alternative diagnostic considerations when benign-appearing cutaneous dermatoses behave peculiarly.…”

Section: Cutaneous Neuroblastomamentioning

confidence: 99%

Pearls and updates: cutaneous signs of systemic malignancy

Paquette

Cotter

Huang

2022

Current Opinion in Pediatrics

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Purpose of reviewChildren with systemic malignancies can present with concomitant dermatological manifestations. Cutaneous findings can occur before, during or after diagnosis. Recognizing these features can aid in diagnosis, inform prognosis, and help determine appropriate treatment. Following a review of the literature published over the past two years, we provide an update on cutaneous signs of pediatric systemic malignancies, concentrating on; leukemia cutis, lymphoma cutis, neuroblastoma, sarcomas, Langerhans cell histiocytosis and paraneoplastic syndromes. Recent findingsAuthors highlight the persistently heterogeneous features of cutaneous manifestations of systemic malignancy. Findings are often nonspecific, and a definitive diagnosis requires skin biopsy with immunophenotyping. Several studies describe dermoscopy features, demonstrating this as a useful tool in clinical evaluation. Genetic mutations underlying the pathogenesis of disease continue to be elucidated. Further, advances in medical treatment led to improved prognosis in many systemic malignancies, with early and aggressive treatment heralding better outcomes. SummaryComprehensive cutaneous evaluation alongside thorough clinical history and review of systems remains of paramount importance as dermatological manifestations of systemic malignancy are notoriously variable with a shared feature of often appearing benign but persisting despite usual treatment. Urgent referral to dermatology is recommended when suspicion for any cutaneous presentation of malignancy arises.

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Section: Cutaneous Neuroblastomamentioning

confidence: 99%