Case of pediatric acute promyelocytic leukemia presenting as extramedullary tumor of the mandible

Abstract

We report herein a rare case involving an infant with APL who presented with an extramedullary tumor of the mandible, whom we treated with good results.

Intraoral granulocytic sarcoma as a manifestation of myelofibrosis: A case report and review of the literature

“…In the present case, the patient was an 81‐year‐old man, presenting a nodular, sessile lesion, measuring about 2 cm at its largest point, and was purple and hemorrhagic. In accordance with the literature, the patient was asymptomatic, but the mandible represented the majority of the oral manifestations, which is not consistent with this case; however, GS has been reported at almost all intraoral sites (Table ).…”

A Case of Acute Promyelocytic Leukemia Presenting as Sternal Infiltrate

“…Out of these 17 patients, 13 patients had presence of concurrent marrow disease along with extramedullary presentation. [1,2,3,6,10,11,12,13,14,15,16,19,20] Out of these 13, in 3 patients bone marrow morphology was negative for abnormal promyelocytes but the presence of disease was being demonstrated by either cytogenetics or molecular methods similar to present case [2,10,6]. While in remaining 10 patients disease was demonstrable on bone marrow morphology as well as on cytogenetics and molecular methods.…”

“…This yields overall complete remission rates of 85-95% and 5-year overall survival rates of 65-70% . [2,11]. This approach Annals of Pathology and Laboratory Medicine, Vol.…”

“…The mean age was 26.7 years (median being 23 years), out of which 6 were children . Table 1 summarizes the clinical and laboratory features of all these cases [1][2][3][4]6,[9][10][11][12][13][14][15][16][17][18][19][20] .The various sites reported were sternal mass in 1 [4] as also seen in the present case, spinal/paraspinal mass in 5 [1,3,17,19,13] , bony lesion of extremities in 2 [2,9] , breast mass in 1 [10] , vertebral or skeletal lesions in 2 [6,12] , mediastinum in 2 [16,18] , cerebellum in 1 [15] , lingual mass in 1 [14], mandibular mass in 1 [11] and 1 patient presented as painful 3rd molar [20]. Out of these 17 patients, 13 patients had presence of concurrent marrow disease along with extramedullary presentation.…”

Promyelocytic sarcoma of the right humerus: an unusual clinical presentation with unique diagnostic and treatment considerations

“…Acute promyelocytic leukemia rarely presents as a mass‐forming lesion without evidence of leukemic involvement, thus making this a highly unique case. Only a few cases have been reported in primary APL presents as a solitary lesion . Although rare, it appears more common in cases with relapsed APL to present as an extramedullary mass compared to primary disease .…”