Case of pyoderma gangrenosum with visceral involvement: severely recurrent disease with lung, spleen, mesorectum and subcutaneous tissue involvement

Pyoderma Gangrenosum with Splenic Abscess- A Rare Association

“…The splenic involvement in the course of PG has been reported at all ages, from 22 to 73 years, corresponding to 10 adult cases reported in the literature. [ 4 5 6 7 8 9 10 11 12 13 ] There are four reports of pediatric PG with associated splenic involvement ranging from a 16-month child to 14 years of age. [ 14 15 16 17 ] It is slightly more frequent in males.…”

“…[ 11 15 ] Laboratory abnormalities observed in these cases include leukocytosis with neutrophilia, anemia, raised erythrocyte sedimentation rate (ESR) and c-reactive protein (CRP). [ 4 5 6 7 8 9 10 11 12 13 14 15 16 17 ] The differential diagnoses for splenic lesions in PG include vasculitis, tumor, and infections. The imaging studies aid in the diagnosis and follow-up for these patients.…”

“…The therapy for PG in patients with underlying visceral involvement involves the use of anti-inflammatory agents, including antibiotics, corticosteroids, immunosuppressive agents, and biologic agents. [ 4 5 6 7 8 9 10 11 12 13 14 15 16 17 ] In most cases, the disease responded well to glucocorticosteroids, whereas a few patients were managed with immunosuppressants like cyclosporine[ 8 9 ,, 10 11 12 13 ] and dapsone. [ 4 ] In refractory cases, biologicals such as infliximab, adalimumab, and etanercept were used.…”

“…A total of 14 cases of pyoderma gangrenosum with splenic involvement have been reported to date with four cases affecting children. [ 4 5 6 7 8 9 10 11 12 13 14 15 16 17 ] We report a case of a 38-year-old female with pyoderma gangrenosum and extracutaneous manifestation presenting as asymptomatic splenic abscess.…”