Case of recurrent cervical polyp-unusual presentation of leiomyosarcoma

Vikram, Archana; Ajith, S; Rajagopal, Rajagopal; Vikram, Surya

doi:10.4103/2321-4848.144340

Cited by 1 publication

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“…Our approach has been inspired by previous reports on the reactivity and applications of the central element 2‐(3‐methylbut‐2‐enyloxy)benzaldehyde ( 10 ) . For example, Rajagopal and Vikram, and others, have previously developed methods that utilized substrate 10 to produce ellipticine alkaloids and other privileged scaffolds. As shown in Scheme , this diversity‐generating reaction transforms relatively simple substrates, such as 10 and 12 a , into complex polycyclic benzopyran and benzoxepine scaffolds of the types II and III , with the potential for broad applications towards biologically relevant targets.…”

Section: Introductionmentioning

confidence: 99%

Intramolecular Diaza‐Diels–Alder Protocol: A New Diastereoselective and Modular One‐Step Synthesis of Constrained Polycyclic Frameworks

Srinivasulu

Reddy

Mazitschek

et al. 2017

Chemistry A European J

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Phenotype-based screening of diverse compound collections generated by privileged substructure-based diversity-oriented synthesis (pDOS) is considered one of the prominent approaches in the discovery of novel drug leads. However, one key challenge that remains is the development of efficient and modular synthetic routes toward the facile access of privileged small-molecule libraries with skeletal and stereochemical complexity and drug-like properties. In this regard, a novel and diverse one-pot procedure for the diastereoselective synthesis of privileged polycyclic benzopyrans and benzoxepines is described herein. These unexplored chemotypes were accessed by utilizing an acid-mediated diaza-Diels-Alder reaction of 2-allyloxy- and/or homoallyloxy benzaldehyde with 2-aminoazine building blocks. Profiling of representative analogues against blood-stage Plasmodium falciparum parasites identified three lead candidates with low micromolar antimalarial activity.

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Section: Introductionmentioning

confidence: 99%